Clinical trials: Experimental, completed
Diabetic Peripheral Neuropathy (DPN), Paresthesia
Study of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by DPN
The purpose of this study is to assess the efficacy of Acetyllevocarnitine Hydrochloride Tablets compared with placebo after 24 weeks, in chinese patients with paresthesia caused by Diabetic Peripheral Neuropathy (DPN).
- Trial name
- NCT05319275
- Testing
- Acetyllevocarnitine Hydrochloride Tablets
- Where
- 34 sites in China
- Volunteers
- 516 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Schizophrenia, Schizoaffective Disorder
Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia
The aim of the project is to investigate the use of Raloxifene (a new form of estrogen) in the treatment of young women with schizophrenia and schizoaffective disorder.
- Trial name
- NCT02354001
- Testing
- Raloxifene hydrochloride
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- The Alfred
Intensive Care, Blood Transfusion
Restrictive and Liberal Transfusion Strategies in Intensive Care
The most effective transfusion practice in critically ill ICU patients is unknown. Currently the data is unclear as to whether a liberal or restrictive transfusion policy is of most benefit to patients in the short and longer…
- Conditions
- Intensive Care, Blood Transfusion, Anemia
- Trial name
- RELIEVE (NCT00944112)
- Testing
- Restrictive RBC Transfusion, Liberal RBC Transfusion
- Where
- 6 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Severe Postpartum Depression
A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)
The primary purpose of this study is to evaluate the safety and tolerability of BRII-296 administered by 2 intramuscular injections, administered with Depo Medrol as assessed by the incidence of adverse events, changes from…
- Trial name
- NCT06057012
- Testing
- BRII-296, Depo Medrol
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brii Biosciences Limited
Advanced Solid Tumor
Special Combination of OBP-301 and Pembrolizumab
This is multicenter, open-label Phase I study to exploratively evaluate the efficacy and safety of OBP-301 in combination with Pembrolizumab in patients with advanced solid tumors.
- Trial name
- NCT03172819
- Testing
- OBP-301, Pembrolizumab
- Where
- Japan
- Volunteers
- 22 people
- Sponsor
- Toshihiko Doi
Stress, Depression
Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families
An urgent and growing need exists for interventions that support the long-term adjustment and mental health needs of OIF/OEF veterans and their relationship partners after the return from deployment.
- Conditions
- Stress, Depression, PTSD, Sleep
- Trial name
- NCT01680419
- Testing
- Mission Reconnect, PREP
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Collinge and Associates, Inc.
ALS
Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS)
To investigate the safety and the efficacy of perampanel in patients with sporadic amyotrophic lateral sclerosis
- Trial name
- NCT03019419
- Testing
- Perampanel
- Where
- 12 sites in Japan
- Volunteers
- 66 people
- Sponsor
- Tokyo Medical University
Fibromyalgia
Mindfulness Intervention for Fibromyalgia Delivered Through a Smartphone App
The purpose of this pilot feasibility study is to evaluate the effects of a smartphone-based mindfulness intervention (MBI) on pain-related outcomes in individuals with fibromyalgia.
- Trial name
- Fibroapp (NCT07032519)
- Testing
- Mindfulness Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brigham and Women's Hospital
Drinking, Alcohol
The Development of a Personalized, Real-time Intervention
The investigators propose to enhance our existing coping motive-specific normative feedback intervention (PFIcope intervention) by capitalizing on EMA/EMI technology to pair real-time affective monitoring with tailored real-time…
- Trial name
- PFIcope+EMI (NCT03518619)
- Testing
- PFIcope+EMI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Butler Hospital
Locally Advanced Rectal Cancer
A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer
An open-label, Phase 1b, dose escalation study evaluating the safety and tolerability of the PARP inhibitor Veliparib in combination with capecitabine and radiation in subjects with locally advanced rectal cancer (LARC).
- Trial name
- NCT01589419
- Testing
- veliparib, capecitabine, radiation
- Where
- 6 sites in United States, Australia
- Volunteers
- 32 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Atrial Fibrillation
Use of Fish Oils to Reduce Recurrence of Atrial Fibrillation Following DC Cardioversion
The purpose of this study is to investigate whether fish oil supplements may be beneficial in preventing the recurrence of atrial fibrillation after cardioversion.
- Trial name
- NCT00232219
- Testing
- Fish oil
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Melbourne Health
Antisepsis
Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate
The present study evaluates the effects of bactericidal load reduction after surgical hand scrub antisepsis using the reference antiseptic product propan-ol-1 60% as control versus a surgical hand scrub antisepsis with addition…
- Trial name
- sorbectol (NCT04454619)
- Testing
- Hand antisepsis with Clorhexidine and solution
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Ortopedico y Quirurgico del Pie
Allergic Conjunctivitis
Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic Conjunctivitis
To evaluate the efficacy of Combo (Drug Product Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic Solution) compared to its individual components and vehicle in a population of subjects with allergic conjunctivitis:
- Trial name
- NCT05579730
- Testing
- Brimonidine tartrate 0.025%/ketotifen fumarate 0.035%, Brimonidine Tartrate 0.025%, Ketotifen Fumarate 0.035%
- Where
- 4 sites in United States
- Volunteers
- 188 people
- Sponsor
- Bausch & Lomb Incorporated
Bipolar I Disorder, Current Episode Depressed
Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression
The purpose of this study is to determine whether creatine monohydrate is effective as an adjuvant treatment for bipolar depression.
- Trial name
- NCT01655030
- Testing
- creatine monohydrate
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Tumor Lysis Syndrome
Febuxostat for Tumor Lysis Syndrome Prevention in Hematologic Malignancies
The purpose of this study is to determine whether febuxostat is superior to allopurinol in the prevention of tumor lysis syndrome (TLS) in patients with hematological malignancies at intermediate or high risk of TLS (according to…
- Trial name
- FLORENCE (NCT01724528)
- Testing
- Febuxostat, Allopurinol
- Volunteers
- 346 people
- Sponsor
- Menarini Group
Peri-Implantitis
Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis
The purpose of the study is to evaluate if using Erbium-doped yttrium aluminium garnet laser, Erbium YAG laser (Er:YAG) laser could have adjunctive benefits to the conventional standard mechanical debridement to ablate the…
- Trial name
- NCT03127228
- Testing
- Standard mechanical debridement, Er:YAG laser-assisted debridement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post-Activation Performance Enhancement (PAPE)
Acute Effects of Resistance Exercise-Based PAPE in Adolescent Basketball Players
This study evaluates the acute effects of resistance exercise-based post-activation performance enhancement (PAPE) on basketball-specific cognitive-motor dual-task performance in male adolescent basketball players.
- Trial name
- PAPE (NCT07851428)
- Testing
- Standardized Basketball Warm-Up, Back Squat PAPE, Deadlift PAPE
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Uludag University
Atopic Dermatitis, Eczema
Effects of an Emollient Containing Postbiotic Saccharomyces and Lactobacillus on Pediatric Atopic Dermatitis
The goal of this study is to investigate whether the use of emollients containing postbiotic Saccharomyces and Lactobacillus can significantly reduce the risk of atopic dermatitis (AD) recurrence in pediatric patients aged 0-6…
- Conditions
- Atopic Dermatitis, Eczema, Emollient
- Trial name
- NCT06474728
- Testing
- Treatment with an Emollient Containing Postbiotic Saccharomyces and Lactobacillus
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Children's Hospital of Fudan University
QT Effects in Healthy Volunteers
Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers
This study will investigate the effect of a single oral dose of moxidectin on the QT interval associated with moxidectin plasma concentrations.
- Trial name
- NCT03012828
- Testing
- Moxidectin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
GIST
A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
The purpose of this study is to evaluate the efficacy and safety of ponatinib in participants with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) following failure of prior tyrosine kinase inhibitor (TKI)…
- Trial name
- GIST (NCT01874665)
- Testing
- Ponatinib
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ariad Pharmaceuticals
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