Clinical trials: Gabapentin, open to volunteers
Central Post-Stroke Pain
Treatment of Post-Stroke Central Pain
To evaluate the short-term analgesic efficacy of stSCS combined with pharmacotherapy compared with pharmacotherapy alone in patients with CPSP, measured by Numerical Rating Scale (NRS) score immediately after treatment.
- Trial name
- NCT07593313
- Testing
- stSCS+Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline), Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanchong Central Hospital
Healthy, Parkinson
Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease
The goal of this observational study is to investigate whether the healthy human brain shows a diversity of optimistic and pessimistic reward signals and whether changes in this distribution in Parkinson's disease (PD) can…
- Conditions
- Healthy, Parkinson, Medication Administration
- Trial name
- OPD (NCT07402928)
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes
The Treatment of Painful Diabetic Neuropathy With Diet
The purpose of this clinical trial is to determine whether targeted nutritional changes can improve symptoms of painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes, Vegan Diet
- Trial name
- NCT07509671
- Testing
- Diet, Medical management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AdventHealth
Chronic Low Back Pain
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes.
- Trial name
- SCEPTER (NCT04142177)
- Testing
- Pain EASE, Tailored exercise, Continued Care and Active Monitoring
- Where
- 19 sites in United States
- Volunteers
- 2,529 people
- Sponsor
- VA Office of Research and Development
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Adolescent Idiopathic Scoliosis (AIS)
Prospective Opioid-Free AIS Fusion
The purpose of this study is to compare the efficacy of a multimodal opioid-free (OF) pain management protocol with a traditional opioid-containing (OC) protocol in pediatric patients undergoing instrumented PSF for idiopathic…
- Trial name
- NCT06935331
- Testing
- Opioid-Free/Opioid-Avoidant, Opioid-Containing
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Interstitial Lung Disease
Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD
Absence of a clear standard of care and approved drug for chronic cough, the commonest symptom in ILD, calls for further research in this area.
- Trial name
- GAZEBO-ILD (NCT07859839)
- Testing
- Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD
- Where
- India
- Volunteers
- 177 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pain, Chronic
Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by…
- Trial name
- I-COAP (NCT06837857)
- Testing
- Opioid
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Theophylline, Sumatriptan
Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache
The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.
- Conditions
- Theophylline, Sumatriptan, Gabapentin, Post-Dural Puncture Headache
- Trial name
- NCT07515456
- Testing
- Theophylline, Sumatriptan, Gabapentin
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
This phase III trial tests if gabapentin can prevent the need for opiate pain medication for mouth sores (oral mucositis) in patients undergoing treatment with chemotherapy and radiation for squamous cell carcinoma of the head…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8, Stage II Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8, Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Trial name
- HOPE (NCT06992427)
- Testing
- Gabapentin, Chemotheraphy, Radiation Therapy
- Where
- 216 sites in United States
- Volunteers
- 228 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Artroscopic Surgery, Pain Management
Suzetrigine for Analgesiain Arthroscopic Rotator Cuff Repair
The goal of this prospective is to determinate if Suzetrigine decreased de use of opioids in patients that undergo an arthroscopic rotator cuff repair.
- Conditions
- Artroscopic Surgery, Pain Management, Pain After Shoulder Surgery, Opioid Consumption
- Trial name
- SOAR (NCT07866638)
- Testing
- Suzetrigine (Journavx), Standard multimodal analgesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery.
- Trial name
- NCT04724252
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Alcohol Use Disorder
Emergency Department-Initiated Medications for Alcohol Use Disorder
The proposed study will be the first randomized clinical trial to evaluate a comprehensive Emergency Department (ED)-based intervention for moderate to severe Alcohol Use Disorder (AUD) combining Screening, Brief Intervention and…
- Trial name
- NCT05827159
- Testing
- Naltrexone Pill, Naltrexone Injection, Brief Negotiation Interview
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Yale University
Emergence Agitation
The Effect of Oral Gabapentin on Emergence Agitation and Delirium in Adult Patients After Nasal Surgery.
Emergence agitation is a postanesthetic phenomenon that develops in the early phase of recovery from general anesthesia, and is characterized by agitation, disorientation, confusion, and possible violent behavior.
- Trial name
- NCT06887998
- Testing
- Gabapentin 600 mg capsules, Gabapentin 400 mg capsules
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic
Bariatric Surgery Analgesia
The Effect of Preoperative Gabapentin on Postoperative Pain Control and Analgesic Requirements Following Bariatric Surgery
The importance of bariatric anesthesia and analgesia research cannot be ignored as it can inform and improve the perioperative protocols for other patients with morbid obesity irrespective of the surgical procedures they are…
- Trial name
- NCT07169006
- Testing
- Group 1, Group 2
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Narcotic Use
Nonopioid Analgesia After Labral Surgery
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of rotator cuff repair: a treatment group given a…
- Trial name
- NCT03825809
- Testing
- Celecoxib, Hydrocodone-Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Elective Surgical Patients, Blood Pressure
Gabapentin and Pressor Response to Intubation
This study evaluates the effectiveness of oral gabapentin in reducing the pressor response (increased MAP, HR, and BP) during laryngoscopic intubation.
- Trial name
- NCT06705101
- Testing
- Gabapentin Group (Group G): Patients will receive 300 mg of oral Gabapentin
- Volunteers
- 144 people
- Sponsor
- Liaquat National Hospital & Medical College
Healthy
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
The purpose of the present study is to assess prospectively the abuse potential of gabapentin when taken with and without oxycodone compared to placebo in healthy non-drug-dependent recreational opioid drug users under fasted…
- Trial name
- NCT07813026
- Testing
- Oxycodone 20mg, gabapentin 600 mg, Gabapentin 1200mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.