Clinical trials: Hydrocortisone
Cerebral Arterio-venous Malformation
Impact of CErebral Endovascular PROcedures on the Systemic Immune responSe Response
In our ICU, it could notice that patients with cerebral arterio-venous malformation (AVM) treated with embolization develop more severe Ventilator Associated Pneumoniae (VAP) compare to other patients hospitalized for…
- Trial name
- PROCESS (NCT05621850)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Limoges
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors
This is a Phase I/II, multicenter, open-label, multi-arm study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin, administered as a single agent or in combination with…
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Neuroblastoma, Solid Tumors
- Trial name
- NCT04029688
- Testing
- Idasanutlin, Venetoclax, Cyclophosphamide
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 38 people
- Sponsor
- Hoffmann-La Roche
Melanoma
Evaluation of Tumor Response to Ipilimumab in the Treatment of Melanoma With Brain Metastases
To assess the response of melanoma with brain metastases to ipilimumab treatment while maintaining acceptable tolerability.
- Trial name
- NCT00623766
- Testing
- Ipilimumab, Corticosteroid: Betamethasone, Corticosteroid: Dexamethasone
- Where
- 14 sites in United States
- Volunteers
- 99 people
- Sponsor
- Bristol-Myers Squibb
Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS)
Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS
single-center, randomized, double-blind, placebo-controlled Phase 2 study to evaluate safety and efficacy of overnight metyrapone in patients with MACS.
- Trial name
- NCT07138274
- Testing
- Metyrapone 250 mg Oral Tablets
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Acute Lymphoblastic Leukemia
Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I
The purpose of this study is to test the good and bad effects of the study drugs bortezomib and vorinostat when they are given in combination with chemotherapy commonly used to treat acute lymphoblastic leukemia (ALL) in infants.
- Trial name
- NCT02553460
- Testing
- ITMHA, Dexamethasone, Mitoxantrone
- Where
- 15 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- St. Jude Children's Research Hospital
Alveolar Ridge Collapse
Volumetric Analysis of Alveolar Ridge Contour Using Sub-epithelial Connective Tissue Graft
This study will monitor the effect of soft tissue augmentation using sub-epithelial connective tissue graft buccal to extraction sockets in anterior maxilla in thin dento-alveolar phenotype; and will evaluate whether it will…
- Trial name
- NCT04482127
- Testing
- SubEpithelial connective graft
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Aluminum Phosphide Poisoned Cases
Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals.
Metal phosphides are commonly utilized for safeguarding stored grains due to their desirable characteristics. They have high potency and the ability to combat different pests and produce non-toxic residues in crops .
- Trial name
- NCT07451561
- Testing
- Gastric lavage with paraffin oil, GIK solution
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Sohag University
Recession, Gingival
Soft Tissue Augmentation Around Immediate Implants In The Esthetic Zone
Following tooth loss, a considerable reduction in hard- and soft-tissue volume can be expected (Tan WL, et al., 2012), (AraujoMG, et al., 2015).
- Trial name
- NCT03802370
- Testing
- connective tissue grafting by Dome Technique
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
Effect of Exenatide on Cortisol Secretion
The primary aim of the study is to describe the effect of single dose of 10 micrograms (μg) exenatide given subcutaneously (s/c) on cortisol secretion. Secondary outcomes involve ACTH and glucose levels.
- Trial name
- NCT03160261
- Testing
- Exenatide Injection
- Where
- Estonia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Post-Traumatic Stress Disorder
Brain Receptor Function in Post-Traumatic Stress Disorder
The purpose of this study is to examine the function of cortisol receptors in post-traumatic stress disorder (PTSD). Patients with PTSD have neurobiological dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis function.
- Trial name
- NCT00046553
- Testing
- RU-486 (Mifepristone)
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Episode
Stress Systems and Psychotherapy in Depression
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis as well as maladaptive activation of the autonomic nervous system (ANS) are discussed as relevant factors in the development of a major depressive episode and as a…
- Trial name
- Bio-COPE (NCT03752853)
- Testing
- internet-based intervention for mild to moderate depression
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Freie Universität Berlin
Burnout, Professional
The Role of Traditional Music Therapy on Burnout Syndrome Among Healthcare Workers: Psycho-Neuro-Immuno-Endocrine Aspects
The goal of this clinical trial study is to learn about the role of traditional music therapy on burnout syndrome among healthcare workers, based on psychology, neurology, immunology, and endocrinology aspects.
- Trial name
- NCT06119451
- Testing
- Traditional Music Therapy
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Indonesia
Immediate Implant Placement
Evaluation of Doxycycline Nanoparticle With Gelatin Sponge on Immediate Implant in Esthetic Region
The goal of this clinical trial is to Evaluate the effect of Doxycycline nanoparticles along with gelatin sponge in immediate implant cases in esthetic zone.
- Trial name
- NCT06809829
- Testing
- Immediate Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Kafrelsheikh University
Temporomandibular Disorders
Oxidative Stress and Opiorphin in Temporomandibular Disorders
The objective of this study is to quantify salivary oxidative stress biomarkers in patients with temporomandibular disorders and to quantify recently isolated endogenous peptide opiorphin in saliva of these patients.
- Trial name
- ROStrO-TMD (NCT03029494)
- Testing
- stabilization splint, Vitamin C
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Croatian Science Foundation
Bone Loss, Alveolar
Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh
Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.
- Trial name
- NCT06559605
- Testing
- zirconia barrier, titanium mesh
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stress, Psychological, Stress, Physiological
Tailored Ecological Momentary Music Intervention for Stress Reduction
Ethnic discrimination is associated with mental and physical health impairments. In view of the negative impact of discrimination on health, it is of great importance to investigate interventions to counteract these negative…
- Conditions
- Stress, Psychological, Stress, Physiological, Discrimination, Racial
- Trial name
- NCT05829031
- Testing
- Targeted music listening
- Where
- Austria
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Fibromyalgia
Body Awareness Therapy and Biomarkers in Fibromyalgia
A randomized trial of Basic Body Awareness Therapy (BBAT) is applied in fibromyalgia patients as compared with a control intervention consisting of stretching.
- Trial name
- BATBF (NCT05555394)
- Testing
- Basic Body Awareness Therapy, Stretching Exercise
- Where
- 2 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Universitat de Lleida
Recovery, Strength
The Effects of KSM-66 Ashwagandha Supplementation on Recovery and Muscle Strength in Academy Athletes
This double-blind, randomised, placebo-controlled trial will examine the effects of 42-day root extract ashwagandha (KSM-66) supplementation on recovery and muscle strength in male and female rugby and water polo players.
- Conditions
- Recovery, Strength, Exercise Training
- Trial name
- NCT07041853
- Testing
- KSM-66 Ashwagandha
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Ramon Llull
Dental Implantation Accuracy
Accuracy of 3D Printed Custom-Made Registration Method for Dynamic Navigation Implant Surgery Using Mininavident in the Esthetic Zone: A Clinical Trial
This clinical trial evaluates the accuracy of a 3D printed custom-made registration method for dynamic navigation implant surgery using the Mininavident system in the esthetic zone of the anterior maxilla.
- Trial name
- NCT07199153
- Testing
- D Printed Custom Registration Marker for Dynamic Navigation
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Sherif Aly Sadek
Mental Disorder, Child
Association Between a Biological Pattern of Dysregulation of the HPA Axis and Mental Disorders in Children Exposed to Early Life Stress
The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.
- Trial name
- ESASP (NCT04363112)
- Testing
- Mini Kid II
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
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