Clinical trials: Hydrocortisone
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04902235
- Testing
- Experimental: CRH administration
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Resistance Training, Sports Nutrition
Effects of Three Carbohydrate Beverages on Resistance Training Performance
This randomized, triple-blinded, counterbalanced crossover trial compared three carbohydrate beverages that provided the same amount of carbohydrate (30 g) but differed in carbohydrate source: dextrose, maltodextrin, and highly…
- Conditions
- Resistance Training, Sports Nutrition, Dietary Carbohydrates
- Trial name
- NCT07874776
- Testing
- Dextrose, Maltodextrin, Highly Branched Cyclic Dextrin
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Chronic Kidney Disease, Hemodialysis
Vibration Massage, Static Stretching Exercise, Intradialytic Muscle Cramps and Stress
Chronic kidney disease (CKD) is characterised by kidney damage that persists for 3 months or longer or an estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m² and is assessed in 6 categories.
- Conditions
- Chronic Kidney Disease, Hemodialysis, Stress
- Trial name
- NCT06759376
- Testing
- Vibration massage, Static stretching exercise, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Figen Akay
Hormonal Contraception
Stress Reactivity and Hormonal Contraception
For almost 60 years, millions of women globally have relied on oral contraceptive (OC) pills for pregnancy prevention and addressing menstrual irregularities.
- Trial name
- NCT06223126
- Testing
- Combined oral contraception, Discontinuation of a combined oral contraception
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Phobia
Cortisol in the Treatment of Phobias
The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.
- Trial name
- NCT00451750
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Acute Hepatitis
ADRENAL FUNCTION IN PATIENTS WITH ACUTE HEPATITIS
A high frequency of adrenal dysfunction (AD) has been reported in severe acute hepatitis (SAH) using the dosage of serum total cortisol (STC).
- Trial name
- CORT-HEPAT (NCT02859584)
- Testing
- Measure OF SERUM TOTAL CORTISOL, SERUM FREE AND SALIVARY CORTISOL
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Immediate Dental Implants
Accuracy of Selective Laser Sinteredcomputer Guided Stents Versus Digital Light Processing Stents
patient with non-restorable tooth in the esthetic zone will be recruited in the study. a traumatic is done and implant will be placed using either digital light processed guides for control group or selective laser sintering…
- Trial name
- RCT (NCT03287934)
- Testing
- selective laser sintered stent, digital light processing(dlp)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
The Effect of Mindfulness-Based Breathing Exercises on Symptom Control
This randomized controlled experimental study aims to evaluate the effect of mindfulness-based breathing exercises on symptom management and salivary cortisol levels in breast cancer patients receiving chemotherapy.
- Trial name
- NCT07474337
- Testing
- Mindfulness-Based Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Firat University
Stress Response
Effect of Nebulized Lignocaine on the Stress Response of Endotracheal Intubation in Pediatrics Undergoing Tonsillectomy Operation Monitored by Rise in Serum Cortisol Level Post Intubation
This randomized clinical trial aims to is examining the effect of preoperative nebulized lidocaine on the stress response to intubation, monitored by rise in serum cortisol level post intubation
- Trial name
- NCT07139730
- Testing
- Lignocaine 2% concentration solution
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Pain
Immunologic Response to Negative Cognition in Persons With Chronic Pain
Principal Investigator/Program Director (Last, First, Middle): Darnall, Beth APS Future Leaders in Pain Small Research Grants Application Page 5 Continuation Format Page Summary: Chronic pain is stressful, both physically and…
- Trial name
- NCT00677911
- Testing
- In-vivo pain catastrophizing induction
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Oregon Health and Science University
Septic Shock
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.
- Trial name
- NCT03872011
- Testing
- Vitamin C,thiamine,hydrocortisone
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Northern Jiangsu People's Hospital
Congenital Adrenal Hyperplasia, Adrenal Insufficiency
Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia
In congenital adrenal hyperplasia (CAH), lifelong hormone replacement therapy is required to treat adrenal insufficiency and to reduce elevated androgen levels. This is essential to ensure "normal" growth and puberty.
- Conditions
- Congenital Adrenal Hyperplasia, Adrenal Insufficiency, Hyperandrogenism; 21-hydroxylase Deficiency
- Trial name
- MASSALIVE (NCT07718230)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adrenal Insufficiency, Adrenal Cancer
Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients
In mitotane treated patients, serum cortisol cannot be used to diagnose hypoadrenalism, since mitotane increases cortisol binding globulin levels (CBG), artificially raising total cortisol.
- Trial name
- NCT03083834
- Testing
- Cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Hyperglycemia
Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock
The purpose of this study is to compare hyperglycemia and other effects, include 28-day mortality and time to reversal of shock between 100 milligrams and 200 milligrams of hydrocortisone as initial dosage in patients with septic…
- Trial name
- NCT02266264
- Testing
- Hydrocortisone
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Srinakharinwirot University
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Aneurysmal Subarachnoid Hemorrhage
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage.
- Trial name
- FLASH (NCT06409364)
- Testing
- Fludrocortisone
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 524 people
- Sponsor
- The George Institute
Leukemia, Lymphocytic, Lymphoblastic Lymphoma
Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)
AINV18P1 is a Phase 1 study where palbociclib will be administrated in combination with a standard re-induction platform in pediatric relapsed Acute Lymphoblastic Leukemia (ALL) and lymphoblastic lymphoma (LL).
- Conditions
- Leukemia, Lymphocytic, Lymphoblastic Lymphoma, T-cell Lymphoma, T-cell Leukemia
- Trial name
- NCT03792256
- Testing
- Palbociclib, Cytarabine, Methotrexate
- Where
- 19 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Oncology Group
Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
Gemcitabine Hydrochloride With or Without Vismodegib in Treating Patients With Recurrent or Metastatic Pancreatic Cancer
This randomized phase I/II trial studies gemcitabine hydrochloride and vismodegib to see how well they work compared with gemcitabine hydrochloride alone in treating patients with recurrent or metastatic pancreatic cancer.
- Conditions
- Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v6 and v7
- Trial name
- NCT01064622
- Testing
- Gemcitabine Hydrochloride, Vismodegib
- Where
- 25 sites in United States
- Volunteers
- 118 people
- Sponsor
- National Cancer Institute (NCI)
Major Depressive Disorder, Anxiety Disorders
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration
The current study will test the causal relationship between elevated levels of cortisol and the serotonin transporter gene (5-HTTLPR) as these factors influence sensitivity to environmental threat.
- Trial name
- 5-HTTLPR (NCT01710202)
- Testing
- Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Domestic Violence, Depression
Cortisol Evaluation in Abuse Survivors
This study looks at the biological effect of domestic violence and abuse (DVA) on women's mental health. The mechanisms through which DVA causes mental disorders are very poorly understood.
- Conditions
- Domestic Violence, Depression, Anxiety, Panic Disorder
- Trial name
- CEASE (NCT01632553)
- Where
- 2 sites in United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Bristol
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