Clinical trials: Hydrocortisone
Septic Shock
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and…
- Trial name
- SHIPSS (NCT03401398)
- Testing
- Hydrocortisone, sodium succinate, Normal saline
- Where
- 44 sites in United States, Brazil and 8 more
- Volunteers
- 500 people
- Sponsor
- Jerry Zimmerman
Cushing Syndrome
The Accuracy of Late Night Urinary Free Cortisol/Creatinine and Hair Cortisol in Cushing's Syndrome Diagnosis
The investigators will conduct a prospective study, in which they will determine sensitivity, specificity and diagnostic accuracy of late evening urinary free cortisol concentration/creatinine and hair cortisol in differentiating…
- Trial name
- NCT02791698
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Bnai Zion Medical Center
Gastric Cancers
Correlation of Psychological Distress and Immune Checkpoint Inhibitors in Gastric Cancer
1. Background Gastric cancer (GC) is a leading global cause of cancer-related mortality, with over 1 million new cases and 769,000 deaths in 2020.
- Trial name
- PDICI (NCT07003334)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Phobic Disorders, Phobias
Glucocorticoid Treatment for Social Phobia
Social phobia is the third most common psychiatric disorder besides depression and alcoholism. Several studies have demonstrated the efficacy of cognitive-behavioral therapy in the treatment of social phobia.
- Trial name
- NCT01574014
- Testing
- CBGT, Hydrocortisone
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation
Post-operative Corticosteroid Treatment After Mitral Valve Surgery
The aim of the study is to intestigate whether three days intravenous corticosteroid management prevent atrial fibrillations in adults after mitral valve surgery.
- Trial name
- MitralPOCS (NCT03682393)
- Testing
- Hydrocortisone
- Where
- Finland
- Sponsor
- Kuopio University Hospital
Premature Newborn
Influence of the Use of Hearing Protection in the Salivary Cortisol Level and in the Sleep of Premature Infants
The aim of this study was to investigate the influence of the use of headphones in salivary cortisol levels in newborns (NB) during periods of nap aimed at noise reduction, brightness and handling NB, measure the concentrations…
- Trial name
- NCT02781168
- Testing
- use of earmuffs
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Stress
The Impacts of Ashwagandha Supplementation on Diurnal Cortisol and Stress Among Women
The purpose of this project is to better understand the role of ashwagandha on the stress response and wellbeing among healthy, stressed women.
- Trial name
- FAB:SR (NCT07647081)
- Testing
- KSM-66 Ashwagandha
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Coronavirus Infection, Pneumonia, Viral
Spironolactone and Dexamethasone in Patients Hospitalized With COVID-19
The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is a rapidly spreading infection of the respiratory tract. Most infected patients have either asymptomatic disease or mild symptoms.
- Trial name
- SPIDEX-II (NCT04826822)
- Testing
- Spironolactone + Dexamethasone, Standard-of-care SARS-CoV-2 treatment
- Where
- Russia
- Volunteers
- 440 people
- Sponsor
- Chita State Regional Clinical Hospital Number 1
Hypotension
Treatment of Hypotension of Prematurity (TOHOP)
Hypotension in the very preterm infant (gestational age [GA] <32 wks) is a frequently occurring clinical problem. Although no real consensus has been reached on the definition of hypotension in these infants, in clinical practice…
- Trial name
- TOHOP (NCT01434251)
- Testing
- Anti-hypotensive treatment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Psychological Stress, Mindfulness
Mechanisms of Mindfulness and Stress Resilience: A Mobile App Mindfulness Training Study
The purpose of this study is to test the active components of mindfulness meditation for reducing psychological stress and improving biomarkers of health.
- Trial name
- NCT02433431
- Testing
- Mindfulness Training, Mindful Attention Only Training, Analytic Thinking Training
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Carnegie Mellon University
Chronic Insomnia
Effects of Connective Tissue Massage in Patients With Chronic Insomnia
This randomized controlled trial will investigate the effects of connective tissue massage on insomnia severity, objective and subjective sleep outcomes, and stress- and autonomic-related biomarkers in adults with chronic…
- Trial name
- NCT07770945
- Testing
- Connective Tissue Massage, Sleep Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Saglik Bilimleri Universitesi
Primary Aldosteronism, Adrenal Cushing Syndrome
Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death
Sudden Cardiac Death is a leading cause of mortality and remains a major public health burden worldwide. Cardiac arrest due to coronary heart disease explains a large proportion of the cases, but if autopsy is not performed the…
- Conditions
- Primary Aldosteronism, Adrenal Cushing Syndrome, Pheochromocytoma, Endocrine Neoplasia
- Trial name
- SuddenDeath (NCT05446779)
- Testing
- Adrenal aldosterone synthase (CYP11B2) staining, Adrenal cortisol synthase (CYP11B1) staining, Histopathological analysis
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Anti-Mullerian Hormone Deficiency
Ovarian Reserve in Intensive Care Patients
Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature.
- Trial name
- NCT06999291
- Testing
- Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Congenital Adrenal Hyperplasia
Development of Healthcare Transition for Patients With Congenital Adrenal Hyperplasia
The purpose of this study is to implement and evaluate the feasibility and acceptability of a structured healthcare transition program for adolescents and young adults with congenital adrenal hyperplasia (CAH).
- Trial name
- NCT07611786
- Testing
- exposure to healthcare transition protocol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Prostate Cancer
Use of Low Dose Ketoconazole in Prostate Cancer That Does Not Respond to Hormone Therapy and Prior Chemotherapy
The purpose of this study is to test the safety of ketoconazole and how well it works after chemotherapy has been used. Ketoconazole at lower doses has been used for fungal infections however has not yet been approved by the Food…
- Trial name
- NCT00895310
- Testing
- Ketoconazole, Hydrocortisone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Atopic Dermatitis
Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2)
This is a Phase 1b, randomized, placebo/vehicle-controlled, double-blinded, multi-center trial. It is designed to assess the safety and efficacy of S.
- Trial name
- NCT06504160
- Testing
- ShA9 Topical Gel, Hydrocortisone Ointment, Clobetasol Ointment
- Where
- 8 sites in United States
- Volunteers
- 86 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Radiotracer, Hypertension
Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)
This study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) to image the adrenal gland.
- Conditions
- Radiotracer, Hypertension, Cholesterol
- Trial name
- NCT04546126
- Testing
- Dexamethasone (Group 2), Cosyntropin (Group 3), PET/CT Scan with FNP-59
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Benjamin Viglianti
Acute Respiratory Distress Syndrome
Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome
Platform adaptive embedded trial for acute respiratory distress syndrome (PETARDS) is a randomized, embedded, multifactorial, adaptive platform trial for ARDS.
- Trial name
- PETARDS (NCT05658692)
- Testing
- protective ventilation, prone position ventilation, glucocorticoid therapy
- Where
- 11 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)
The primary objectives of this study are to evaluate the safety and tolerability of opevesostat in the treatment of male Chinese participants with metastatic castration-resistant prostate cancer (mCRPC) and to characterize the…
- Trial name
- NCT06136598
- Testing
- Opevesostat, Dexamethasone, Fludrocortisone
- Where
- 3 sites in China
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
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