Clinical trials: Hydrocortisone
Adrenal Insufficiency
Cardiovascular Status in Adrenal Insufficiency
Within this trial, the cardiovascular status and metabolic profile of patients with chronic primary adrenal insufficiency is evaluated.
- Trial name
- CVCORT-AI (NCT03426319)
- Testing
- Cardiovascular evaluation
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Wuerzburg University Hospital
Healthy
Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
CAR is short for cortisol awakening response. The neural mechanism of CAR effect on high-order cognition and social cognition is less known...
- Trial name
- NMCARSEHHSC (NCT02799134)
- Testing
- Dexamethasone, Vitamin C
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- qinshaozheng
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Depression
Fludrocortisone and Information Processing in Healthy Volunteers
Stimulating the mineralocorticoid receptor (MR) may restore a disturbed balance as seen in depression. In this double-blind, randomized, placebo-controlled trial the investigators will test the effects of a single dose (500mg)…
- Trial name
- NCT01648998
- Testing
- Fludrocortisone
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Dry Eye
Efficacy of Quantum Molecular Resonance Combined With Intense Pulsed Light in Mixed Dry Eye
This study examines the effectiveness of combining Quantum Molecular Resonance (QMR) and Intense Pulsed Light (IPL) treatments for Mixed Dry Eye, a condition where both tear production and tear quality are compromised.
- Trial name
- NCT06576245
- Testing
- Quantum Molecular Resonance (QMR) Therapy, Intense Pulsed Light (IPL) Therapy, Tear Substitute Treatment (Supportive Therapy)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Seville
Injectable Platelet Rich Fibrin and Microneedling in Papilla Reconstruction, Interdental Papillae Reconstruction
Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone
The currently available non-surgical techniques for papillary reconstruction did not provide long term maintenance of papillary regeneration, Surgical techniques are invasive and the results are unpredictable .
- Trial name
- iPRFandMN (NCT06021301)
- Testing
- Platelet-Rich Fibrin and Microneedling
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adrenal Insufficiency
Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism
Despite optimized hydrocortisone replacement regimes, many patients with adrenal insufficiency (AI) suffer from impaired quality of life (QoL).
- Trial name
- PlenadrEMA (NCT02282150)
- Testing
- Hydrocortisone, Plenadren
- Volunteers
- 30 people
- Sponsor
- Ulla Feldt-Rasmussen
Health Behavior, Quality of Life
Yoga Effects on Heart Rate Variability and Electroencephalography
Since yoga breathing exercises are traditionally used to tranquilize the mind, and have a well-known positive effect on the cardiovascular system, it is our hypothesis that a respiratory yoga exercise named bhastrika pranayama…
- Trial name
- NCT01866683
- Testing
- 1 month respiratory training, 1 month waiting period
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Anxiety
Dental Anxiety in Children and Salivary Cortisol Levels
Objective: This study aimed to assess whether pediatric dental anxiety is due to the day of dental appointment, to the dental chair, or to the dental treatment procedure during the course of the first dental treatment in…
- Trial name
- NCT04338854
- Testing
- Restorative Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Inonu University
Type D Personality, Trauma, Psychological
The Efficacy of a Psychosomatic Intervention
This study examines the efficacy of a psychosensory intervention in relation to: Resilience, Type D personality, and physiological effects (on blood pressure, heart rate and salivary cortisol) in a group of people who have…
- Trial name
- NCT03568591
- Testing
- Psychosensory Therapy
- Where
- United Kingdom
- Volunteers
- 125 people
- Sponsor
- Cardiff Metropolitan University
Sepsis, Tuberculosis
STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis
Sepsis, a life-threatening condition due to a dysregulated response to infection, is the leading cause of global mortality and is frequently driven by tuberculosis (TB) and drug-resistant bacteria in sub-Saharan Africa…
- Trial name
- STARS (NCT07332325)
- Testing
- Hydrocortisone administration, Expanded antimicrobial therapy
- Where
- 4 sites in Tanzania, Uganda
- Volunteers
- 344 people
- Sponsor
- University of Virginia
Individuality
Effects of Mineralocorticoid Receptor Stimulation on Cognition
In this study the effects of mineralocorticoid stimulation on social cognition will be investigated in healthy young individuals.
- Trial name
- MR-STIM (NCT02478034)
- Testing
- Fludrocortisone
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Crohn Disease
Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease
Crohn's disease exclusion diet (CDED) is a whole-food diet coupled with partial enteral nutrition. The main objective of this trial is to assess whether CDED is superior to corticosteroids, in terms of endoscopic response, in…
- Trial name
- PARADISE (NCT05284136)
- Testing
- Crohn's disease exclusion diet (CDED), Oral prednisolone
- Where
- 2 sites in France, Netherlands
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Prostate Cancer
A Study of the Absorption, Distribution, Metabolism, and Elimination of Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-008)
This is a study of opevesostat in healthy adult male participants. The purpose of this study is to understand the absorption, distribution, metabolism, and elimination of opevesostat in humans, as well as its pharmacokinetics…
- Trial name
- NCT06566989
- Testing
- [¹⁴C]Opevesostat, Prednisone, Fludrocortisone
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Volunteers
Effects of Substance P Antagonists on Adrenal Secretion
Data from the literature and previous in vitro research conducted in the investigators' laboratory (INSERM U413/EA4310, University of Rouen) suggest that adrenal corticosteroid secretion might be controlled by sympathetic nervous…
- Trial name
- APHOS (NCT00977223)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Rheumatoid Arthritis
Cortisol Circadian Rhythm in Patients With RA
The European League Against Rheumatism (EULAR), acknowledging the critical issue of the complications, of long term treatment with glucocorticoids in the most recent update of the management guidelines for Rheumatoid arthritis…
- Trial name
- CortRyRA (NCT05671627)
- Testing
- DMARDs
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Mature B-Cell Leukemia Burkitt Type, Burkitt Lymphoma (BL)
Treatment of Mature B-ALL and Burkitt Lymphoma (BL) in Adult Patients. BURKIMAB-14.
Rituximab combined with a specific intensive chemotherapy is considered the standard treatment for newly diagnosed patients with mature B leukemia/lymphoma. However, the toxicity of this therapy is high.
- Conditions
- Mature B-Cell Leukemia Burkitt Type, Burkitt Lymphoma (BL), Unclassifiable Lymphoma Between DCBL and BL
- Trial name
- NCT05049473
- Testing
- Rituximab, Methotrexate, Dexamethasone
- Where
- 29 sites in Spain
- Volunteers
- 100 people
- Sponsor
- PETHEMA Foundation
Anorexia in Adolescence
New Treatment Perspectives in Adolescents With Anorexia Nervosa: the Efficacy of Non-invasive Brain-directed Treatment
The present randomized, double blind, placebo-controlled trial aims at evaluating the efficacy of a tDCS treatment in improving the clinical outcome of adolescents with AN and investigate brain mechanisms acting in AN.
- Trial name
- NCT05674266
- Testing
- AN Active tDCS
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Midfacial Mucosal Recession
Association Between Peri-implant Soft Tissue Thickness and Midfacial Marginal Mucosal Recession
Peri-implant mucosal recession in the anterior esthetic zone is a clinically important complication because it can expose implant components, compromise esthetics, and reduce patient satisfaction.
- Trial name
- NCT07899320
- Testing
- immediate implant placement
- Volunteers
- 100 people
- Sponsor
- International Dental Contiuing Education
Mild-to-Moderate Stress
Prebiotic Effects on Anxiety, Cortisol, and Emotional Processing in Mild-to-Moderately Stressed Adults
The levels of stress that we experience as a population are continuing to rise due to financial, social and work pressures, particularly in mid-life where additional factors such as family and career often compound these issues.
- Trial name
- PEACE (NCT06991023)
- Testing
- Prebiotic (Bimuno®)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University of Reading
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