Clinical trials: Hydrocortisone
Primary Aldosteronism Due to Adrenal Hyperplasia
Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT
This multicenter randomized controlled trial plans to enroll primary aldosteronism (PA) patients who meet the following criteria: confirmed unilateral dominant secretion by adrenal vein sampling (AVS), willingness to undergo…
- Trial name
- GRAFT_PA (NCT07558811)
- Testing
- Intervention_1
- Volunteers
- 90 people
- Sponsor
- Ruijin Hospital
Lumbar Disc Herniation, Preoperative Anxiety
Comparison of Virtual Reality-Based and Routine Preoperative Education on Surgical Anxiety and Salivary Cortisol
This randomized controlled pilot study aims to compare the effects of virtual reality-based preoperative education and routine preoperative education on surgical anxiety in patients undergoing lumbar disc surgery.
- Trial name
- NCT07443111
- Testing
- Virtual Reality-Based Preoperative Education, Routine Preoperative Education
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University
Duchenne Muscular Dystrophy
Determine the Safety and Dose of EN001 in Patients With Duchenne Muscular Dystrophy(DMD)
Open-label, Dose-escalation, Phase 1 Clinical Trial to Determine the Safety and Dose of EN001 in Patients with Duchenne Muscular Dystrophy(DMD)
- Trial name
- NCT05338099
- Testing
- EN001
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- ENCell
Cushing Syndrome
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT
The incidence of Cushing syndrome (CS) is 1.2-3.2 cases per million per year, of which adrenocorticotropic Hormone (ACTH)-dependent disease comprises approximately 70-80% of cases.
- Trial name
- Ga-68 mDesmo (NCT06962202)
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Prostate Cancer Metastatic
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall…
- Trial name
- OMAHA-003 (NCT06136624)
- Testing
- Opevesostat, Abiraterone acetate, Enzalutamide
- Where
- 288 sites in United States, Argentina and 34 more
- Volunteers
- 1,310 people
- Sponsor
- Merck Sharp & Dohme LLC
Adrenal Hyperplasia, Congenital, 21-hydroxylase Deficiency
Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.
The risk of adrenal insufficiency in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is not well documented.
- Trial name
- EVAF-21 (NCT01862380)
- Testing
- Functional explorations
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Graft Rejection
Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation
The purpose of this research study is to compare the effects of the two most commonly used anti-T cell induction agents(alemtuzumab and rabbit anti-thymocyte globulin) to prevent rejection in kidney and pancreas transplant…
- Trial name
- NCT00331162
- Testing
- Alemtuzumab, Anti-Thymocyte Globulin
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus, Type 2, Obesity
Type 2 Diabetes, Obesity and Cortisol Excess
The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion
- Trial name
- DOCOR (NCT05759637)
- Testing
- 1mg DST
- Where
- 5 sites in Italy
- Volunteers
- 3,200 people
- Sponsor
- Istituto Auxologico Italiano
Mild Cognitive Impairment, Dementia, Mild
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
The goal of this clinical trial is to compare a precision medicine approach to the standard-of-care for people with mild cognitive impairment or early-stage dementia.
- Trial name
- EVANTHEA (NCT05894954)
- Testing
- Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alzheimer's Prevention and Reversal Project, Inc.
COVID-19
Relation Between COVID-19 Pts and Hyponatremia in Adreno Ortical Insufficient Patients.
Hyponatremia in COVID-19 patients with adrenal insufficiency
- Trial name
- NCT05408481
- Testing
- Serum cortisol level
- Volunteers
- 50 people
- Sponsor
- Assiut University
Food Insecurity
Cortisol and Food Insecurity
This study used a within-subjects design in a sample of individuals with a range of food insecurity recruited from the Los Angeles community (N = 400; 44.5% men).
- Trial name
- NCT05191030
- Testing
- High-Stress Intervention
- Where
- United States
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
PostTraumatic Stress Disorder
PTSD Among Victims of Sexual Abuse and Changes in Structural and Functional Brain Connectivity
The goal of this study is to identify the early modifications in fronto-temporal connectivity in female victims who developed PTSD, compared to female victims who did not develop the disorder, and to healthy control females.
- Trial name
- COPTSD (NCT01405495)
- Testing
- MRI-based techniques (sMRI, fMRI, DTI, ASL)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Covid-19, Hypoxia
Hydrocortisone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of low-dose hydrocortisone in patients with COVID-19 and severe hypoxia.
- Trial name
- COVID STEROID (NCT04348305)
- Testing
- Hydrocortisone, Sodium Chloride 9mg/mL
- Where
- 14 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Scandinavian Critical Care Trials Group
Refractory Acute Lymphoblastic Leukemia, Relapsed Acute Lymphoblastic Leukemia
Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL
The investigators postulate that Pevonedistat will be effective in patients with relapsed/refractory acute lymphoblastic leukemia (ALL) when combined with a standard backbone ALL chemotherapy regimen.
- Trial name
- NCT03349281
- Testing
- Pevonedistat, Vincristine, Dexamethasone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Julio Barredo, MD
Phimosis
Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children
Topical steroids are used as treatment for non-retractile foreskin in children for decades, but, there are disagreement among physicians about the optimum potency of the agent used.
- Trial name
- TopSteP (NCT00933023)
- Testing
- hydrocortisone, Betamethasone
- Where
- United Kingdom
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Primary Aldosteronism, Autonomous Cortisol Secretion
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the…
- Trial name
- NCT06833437
- Testing
- 68Ga-Pentixafor PET/CT, AVS
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qifu Li
Post Traumatic Stress Disorder
A Correlation Between Hair Cortisol Levels and the Development of Post Traumatic Stress Disorder (PTSD)
This observational study follows subjects who have been exposed to a traumatic event and are at risk of developing PTSD symptoms.
- Trial name
- NCT02033395
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Nursing Caries, Newborn Illness
The Effect of Swaddling Method on Stress Level in Newborns Administration to Nasal CPAP
Transient tachypnea of newborn (TTN) causes 42.5%-60% of non-infectious respiratory distress cases in newborns, it is seen in only 1% of all newborns.
- Conditions
- Nursing Caries, Newborn Illness, Nurse's Role
- Trial name
- NCT05657977
- Testing
- nonpharmacologic intervention (swaddling)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
Adrenal Cortex Diseases, Infant Morbidity
Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery
Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone results in similar drug levels for all patients and to characterize the relationship between these drug levels and the innate stress…
- Trial name
- NCT01839812
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.