Clinical trials: Hydrocortisone, completed
Congenital Adrenal Hyperplasia
Long-term Safety Study of Chronocort in the Treatment of Participants With Congenital Adrenal Hyperplasia
This phase III study is an open-label extension study to be conducted at approximately 21 investigational sites across 3 countries.
- Trial name
- NCT05299554
- Testing
- Chronocort
- Where
- 21 sites in United States, France and 1 more
- Volunteers
- 76 people
- Sponsor
- Immedica Pharma AB
Adrenal Incidentaloma, Hypercortisolism
Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls
The goal of this observational study is to evaluate the diagnostic accuracy of salivary cortisol compared with serum cortisol after a 1 mg overnight dexamethasone suppression test in participants (N = 100) with adrenal…
- Trial name
- SALICOR (NCT07350031)
- Testing
- 1 mg overnight dexamethasone suppression test
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dental Anxiety
Dental Anxiety in Children and Salivary Cortisol Levels
Objective: This study aimed to assess whether pediatric dental anxiety is due to the day of dental appointment, to the dental chair, or to the dental treatment procedure during the course of the first dental treatment in…
- Trial name
- NCT04338854
- Testing
- Restorative Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Inonu University
Drug/Agent Toxicity by Tissue/Organ, Leukemia
05-001: Treatment of Acute Lymphoblastic Leukemia in Children
RATIONALE: L-asparaginase is an important component of treatment for childhood acute lymphoblastic leukemia, but is also associated with notable side-effects, including hypersensitivity, pancreatitis, and thrombosis.
- Trial name
- NCT00400946
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 8 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Alcohol Craving, Psychological Stress
Acute Effects of Cortisol on Alcohol Craving in Alcohol Dependence
To investigate the effects of cortisol on alcohol craving and stress reactivity in alcohol addicted subjects. Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication.
- Conditions
- Alcohol Craving, Psychological Stress, Physiological Stress
- Trial name
- CAR-Bern 2013 (NCT02196142)
- Testing
- Cortisol 20mg
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COVID-19, Adrenal Insufficiency
Assessment of Diurnal Salivary Cortisol Production in COVID-19
In the year of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic several studies have focused on the effect of the COVID-19 on the adrenal cortex, demonstrating conflicting results.
- Conditions
- COVID-19, Adrenal Insufficiency, Adrenal Hyperfunction
- Trial name
- NCT04988269
- Testing
- Blood sampling, Saliva sampling
- Where
- Greece
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Parkinson Disease, Huntington Disease
Measuring Cortisol Levels in Persons With Parkinson's (PD)
The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls.
- Trial name
- CORT-PD (NCT02727270)
- Testing
- No Intervention - Observational Study
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain, Sleep
Effects of Tactile Touch on Chronic Pain in Parkinson´s Disease
The Parkitouch study compared the effects on pain, sleep quality and HealthRelated Quality of Life (HRQoL) among 44 participants with Parkinson´s Disease for at least two years and chronic pain.The two groups were randomized to…
- Trial name
- NCT01734876
- Testing
- Tactile Touch, Rest To Music
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Region Jönköping County
Cytochrome P450 Oxidoreductase Deficiency, Hypertension
Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase Deficiency
This study investigates the etiology of hypertension and endothelial damage in patients with Cytochrome P450 Oxidoreductase (POR) deficiency.
- Conditions
- Cytochrome P450 Oxidoreductase Deficiency, Hypertension, Endothelial Dysfunction, Congenital Adrenal Hyperplasia
- Trial name
- PORENDO (NCT06756620)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ozge Bayrak Demirel
Bronchopulmonary Dysplasia
PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates
There is increasing evidence linking a fetal and early neonatal systemic inflammatory response syndrome to the subsequent development of bronchopulmonary dysplasia (BPD) and white matter injury (WMI) in very preterm infants.
- Trial name
- PREMILOC (NCT00623740)
- Testing
- hydrocortisone
- Where
- France
- Volunteers
- 523 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nursing Caries
Nursing Care in Threat of Preterm Birth
Relaxation-Focused Nursing Care which is formed by using these two models is composed of; positive language, positive environment and reducing stressors.
- Trial name
- NCT04045197
- Testing
- Relaxation Focused Nursing Care
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hülya Özberk
Exercise Physiology, Cardiorespiratory Fitness
IL-6 and Cortisol Responses to Cycling Exercise
This study aimed to investigate salivary interleukin-6 (IL-6) and cortisol responses following short-term and long-term cycling exercise in team athletes with different cardiorespiratory fitness levels.
- Conditions
- Exercise Physiology, Cardiorespiratory Fitness, Interleukin-6, Cortisol
- Trial name
- NCT07681362
- Testing
- Wingate Anaerobic Cycling Test, YMCA Submaximal Cycling Test
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Alteration of Cognitive Function
Exercise and Cognition Trials
The purpose of this study is to determine whether an acute bout of exercise may temporarily enhance cognitive function (such as memory or attention span) by measuring behavioral performance on cognitive tests, as well as…
- Trial name
- EXACT (NCT02958735)
- Testing
- Exercise Challenge
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005)
The purpose of this study is to assess the efficacy and safety of opevesostat in the treatment of Japanese men with metastatic castration-resistant prostate cancer (mCRPC) previously treated with Next Generation Hormonal Agent…
- Trial name
- NCT06104449
- Testing
- Opevesostat, Dexamethasone, Fludrocortisone acetate
- Where
- 3 sites in Japan
- Volunteers
- 7 people
- Sponsor
- Merck Sharp & Dohme LLC
Infant, Premature, Diseases
Study of the Effect of Hydrocortisone Administered for the Prevention of Pulmonary Bronchodysplasia (PREMILOC Trial) on the Determinants of Systemic Blood Pressure in Children (PREMILOCAP)
The risk of Arterial Hypertension (HTA) is increased in very premature infants and hydrocortisone administered in the neonatal period could modify this risk.
- Trial name
- PREMILOCAP (NCT05451264)
- Testing
- blood pressure measurement
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psoriasis
Efficacy and Safety of Etanercept 50 mg Once Weekly Plus As Needed Topical Agent in Moderate to Severe Plaque Psoriasis
To estimate the difference in effectiveness between treatment with etanercept 50 mg twice weekly (BIW) and treatment with etanercept 50 mg once weekly (QW) plus an as needed (PRN) topical agent for 12 weeks in adults with…
- Trial name
- REFINE (NCT01313221)
- Testing
- etanercept, Topical agents
- Where
- 24 sites in Canada
- Volunteers
- 310 people
- Sponsor
- Amgen
Advanced Malignant Neoplasm, Dermatologic Complication
Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab
This randomized phase II trial studies how well giving spironolactone works in preventing rash in patients with cancer that has spread to other places in the body and are receiving panitumumab and cetuximab.
- Trial name
- NCT01867294
- Testing
- Doxycycline, Management of Therapy Complications, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Academic and Community Cancer Research United
Combined Oral Contraceptive Cessation
CBG Normalization After Discontinuation of COC's
In this study, the investigators aim to examine after which duration corticosteroid-binding globulin (CBG) and total cortisol concentrations return to normal after cessation of the combined oral contraceptive pill in healthy…
- Trial name
- NCT06802211
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Dental Anxiety, Symptomatic Irreversible Pulpitis
Effect of Dental Anxiety on Mandibular Anesthesia Success
The goal of this clinical trial is to evaluate the effect of dental anxiety on the success of mandibular anesthesia in patients with symptomatic irreversible pulpitis in mandibular molar teeth.
- Trial name
- NCT07124273
- Testing
- Standardized Mandibular Anesthesia Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Kutahya Health Sciences University