Clinical trials: Hydrocortisone, completed
Adrenal Insufficiency
An Investigational Study of Hydrocortisone
This study will investigate a new drug called Infacort®; a newly-developed immediate release formulation of a well-established drug called hydrocortisone.
- Trial name
- NCT01960530
- Testing
- Hydrocortisone granules, Hydrocortisone Tablet, i.v. Hydrocortisone Injection
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Cannabis Use Disorder
Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder
This research project proposes a novel approach to elucidate the biological adaptations associated with Cannabis Use Disorder and to assess whether such adaptations are predictive of higher drug craving in response to both drug…
- Trial name
- NCT04116619
- Testing
- Guided Imagery Laboratory Session
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Yale University
Covid19
Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)
This study looks at the safety and effectiveness of Remdesivir in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure.
- Trial name
- NCT06729593
- Testing
- Remdesivir, Corticosteroid
- Where
- 40 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stomatitis, Oral Mucositis
Miracle Mouthwash Plus Hydrocortisone vs Prednisolone Mouth Rinse for Mouth Sores Caused by Everolimus
This is a randomized Phase 2 study to evaluate two different steroid-based mouth rinses (Miracle Mouth Wash plus hydrocortisone versus prednisolone oral rinse) for the prevention or treatment of everolimus-associated stomatitis…
- Conditions
- Stomatitis, Oral Mucositis, Neoplasm of the Breast, Malignant Tumor of Breast
- Trial name
- NCT02229136
- Testing
- Miracle Mouthwash Plus Hydrocortisone, Prednisolone
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- US Oncology Research
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3
It has been found that in some cases, when a person with Diabetes Mellitus has an episode of low blood sugar,or hypoglycemia, and then later exercises, he or she is vulnerable to another bout of hypoglycemia during that exercise.
- Trial name
- NCT00742521
- Testing
- glucose clamp
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Corticotropin Deficiency, Fasting
Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone
Selected patients will be randomised to either hydrocortisone or prednisolone. Each treatment period is of 14 days. Abnormal clinical symptoms, blood glucose and quality of life will be monitored.
- Trial name
- NCT03585829
- Testing
- Hydrocortisone, Prednisolone
- Where
- Tunisia
- Volunteers
- 53 people
- Sponsor
- University Tunis El Manar
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome
The purpose of this study is to test the safety of selinexor (KPT-330) and to find the highest dose of selinexor (KPT-330) that can be given safely when it is combined with two chemotherapy drugs (fludarabine and cytarabine).
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndrome (MDS), Mixed Phenotype Acute Leukemia (MPAL)
- Trial name
- NCT02212561
- Testing
- Selinexor, Fludarabine, Cytarabine
- Where
- 6 sites in United States
- Volunteers
- 19 people
- Sponsor
- St. Jude Children's Research Hospital
Stress, Job
Stress Level Among Dentists in Performing Treatment
Purpose: To evaluate the stress levels of dentists working under clinical, deep sedation, or general anaesthesia. Methods: Blood pressure (Systolic, Diastolic blood pressure), Pulse value, O2 saturations were measured, and saliva…
- Trial name
- NCT05394480
- Testing
- Blood pressure (Systolic, Diastolic), Pulse value, O2 saturations were measured.
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Tooth Loss and Rehabillitation
Custom Provisionalisation
Fully digital immediate implant treatment by means of fully guided implant placement and custom designed provisionalisation with a individual designed abutment and temporary PMMA crown leads to better esthetic outcomes than free…
- Trial name
- Azento (NCT07731854)
- Testing
- Fully guided implant placement, Free handed implant placement, individualised abutment + digital prepared provisional crown
- Where
- 2 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Transportation Accidents, Drunk Driving
Design and Implementation of a Drunk Driving Detection System
To analyse driving behavior of individuals under the influence of alcohol using a validated research driving simulator. Based on the driving variables provided by the simulator the investigators aim at establishing algorithms…
- Conditions
- Transportation Accidents, Drunk Driving, Alcohol Drinking, Impaired Driving
- Trial name
- DRIVE (NCT04980846)
- Testing
- Driving under the influence of alcohol with a driving simulator
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bern
Psychological Distress
The Psychological Effect of the Covid-19 Pandemic
At the end of 2019, the novel coronavirus disease (Covid-19), which emerged in China, has become a public health emergency of international concern.
- Trial name
- NCT05503589
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Diabetes Mellitus, Type 2
Glucocorticoids and Skin Healing in Diabetes (GC-SHealD)
The study aims to investigate effects of inhibiting glucocorticoid activation on skin function and wound healing in patients with type 2 diabetes.
- Trial name
- GC-SHealD (NCT03313297)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Leeds
Autism Spectrum Disorder, Mental Disorders
Physiological Mechanisms of Therapeutic Horseback Riding Intervention Effects in a Psychiatric Population of ASD Youth
This randomized control trial (RCT) seeks to assess the mechanisms underlying Therapeutic Horseback Riding's (THR) previously observed significant positive effects on ASD youth, particularly those with co-occurring psychiatric…
- Trial name
- NCT04606966
- Testing
- Therapeutic Horseback Riding, Barn Activity, Hybrid
- Where
- 2 sites in United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Treatment Outcome in Major Depressive Disorder
Major Depressive Disorder (MDD) is one of the most severe and frequently occurring brain disorders worldwide. It has been linked to serotonergic dysfunction, sexual dysfunction, vulnerability to stress and neuro-inflammation.
- Trial name
- NCT02869035
- Testing
- Escitalopram, Duloxetine
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis
Vitamin C, Thiamine, and Steroids in Sepsis
The VItamin C, Thiamine And Steroids in Sepsis (VICTAS) Study is a double-blind, placebo-controlled, adaptive randomized clinical trial designed to investigate the efficacy of the combined use of vitamin C, thiamine and…
- Trial name
- VICTAS (NCT03509350)
- Testing
- Vitamin C, Thiamine, Hydrocortisone
- Where
- 43 sites in United States
- Volunteers
- 501 people
- Sponsor
- Emory University
Addison Disease, Adrenal Hyperplasia Congenital
Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia
The aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy.
- Trial name
- NCT02096510
- Testing
- Solu-Cortef, Cortef
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- Haukeland University Hospital
Pediatric Cancer
Efficacy Of Child Yoga Programme on Quality of Life of Pediatric Oncology Patients.
Pediatric oncology patients experience physical and psycho-social symptoms that negatively affect their quality of life during treatment.
- Trial name
- NCT04932720
- Testing
- chıld yoga programme
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Jet Lag
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
This study will examine the effects of cortisol (hydrocortisone), melatonin, a combination of cortisol and melatonin, and placebo (an inactive substance) on jet lag symptoms.
- Trial name
- NCT00097474
- Testing
- Hydrocortisone, Melatonin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Adrenal Insufficiency
Neonatal, Infant and Toddler Salivary Study (NITS Study)
Currently, the only way to analyse glucocorticoids for the screening or diagnosis of AI in young children is via plasma obtained by invasive capillary or venous blood sampling.
- Trial name
- NITS (NCT05350982)
- Testing
- SalivaBio +/- SaliPac
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Psoriasis Vulgaris
Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin Folds
There are few therapies suitable for the treatment of psoriasis on the face and skin folds. As these areas are sensitive, irritation and other adverse reactions are more common than elsewhere on the body.
- Trial name
- NCT00704262
- Testing
- Calcipotriol plus hydrocortisone (LEO 80190)
- Where
- 11 sites in United States, Canada and 2 more
- Volunteers
- 33 people
- Sponsor
- LEO Pharma