Clinical trials: Hydrocortisone
Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion
SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome
This is a randomized, placebo-controlled, study of SPI-62 in subjects with ACTH-dependent Cushing's syndrome caused by a non-adrenal tumor.
- Conditions
- Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion, Cortisol Excess, Cortisol; Hypersecretion
- Trial name
- RESCUE (NCT05307328)
- Testing
- SPI-62
- Where
- 12 sites in United States, Bulgaria and 1 more
- Volunteers
- 26 people
- Sponsor
- Sparrow Pharmaceuticals
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Systemic Inflammatory Response Syndrome, Posttraumatic Stress Disorder
Influence of Hydrocortisone on Immunologic Markers and Health Care Related Quality of Life in Patients After Cardiac Surgery
Hydrocortisone has been shown to improve the early outcome of high risk patients after cardiac surgery. A potential mechanism resulting in this effect may be its immunomodulatory action.
- Trial name
- NCT00490828
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Adrenal Insufficiency
THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone
To describe clinical outcomes and both primary and secondary care health care resource use in patients who have been prescribed either immediate-release (IR) hydrocortisone or modified-release (MR) hydrocortisone or prednisolone…
- Trial name
- NCT03013166
- Testing
- Corticosteroid medication
- Volunteers
- 3,000 people
- Sponsor
- Shire
Cushing Syndrome
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT
The incidence of Cushing syndrome (CS) is 1.2-3.2 cases per million per year, of which adrenocorticotropic Hormone (ACTH)-dependent disease comprises approximately 70-80% of cases.
- Trial name
- Ga-68 mDesmo (NCT06962202)
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Post Traumatic Stress Disorder
A Correlation Between Hair Cortisol Levels and the Development of Post Traumatic Stress Disorder (PTSD)
This observational study follows subjects who have been exposed to a traumatic event and are at risk of developing PTSD symptoms.
- Trial name
- NCT02033395
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Dental Implants
Computer Guided Versus Free Hand Immediate Implant Placement
Patients with remaining root or fractured teeth indicated for extraction in the esthetic zone will be recruited to the study. After extraction of the tooth implant will be placed immediately, implants will be placed either by…
- Trial name
- NCT03230500
- Testing
- Computer guided implant placement
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cortisol Resistance, Negative Feedback
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.
- Conditions
- Cortisol Resistance, Negative Feedback, ACTH, Mineralcorticoid
- Trial name
- NCT01294319
- Testing
- Mifepristone, Spironolactone, Combined
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiogenic Shock
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.
The purpose of this randomized controlled trial is to evaluate the hemodynamic effect of low dose corticosteroid therapy (hydrocortisone and fludrocortisone) in the treatment of adult cardiogenic shock.
- Trial name
- COCCA (NCT03773822)
- Testing
- Hydrocortisone + Flucortac
- Where
- 21 sites in France
- Volunteers
- 380 people
- Sponsor
- CMC Ambroise Paré
Developmental Disability, Chronic Disease
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder…
- Conditions
- Developmental Disability, Chronic Disease, Down Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03602378
- Testing
- salivary cortisol, Holter Medilog AR12 Plus, Polar V800
- Where
- 2 sites in Croatia
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Opioid Withdrawal, Opioid Use Disorder
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
The primary objective of this trial is to measure changes in physiologic signals to quantify the status of the autonomic nervous system during opioid withdrawal and cravings.
- Trial name
- NCT06487533
- Testing
- EmbracePlus Smartwatch, Corti Sensor
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Spark Biomedical, Inc.
Sleep Disorder
Associations of Socioeconomic Adversity and Sleep With Allostatic Load Among Toddlers
A longitudinal study to examine the relationships among sleep characteristics, stress, and child behavior problems in a community sample of toddlers (12-24 months- ages 12-15 months at enrollment) living in socioeconomically…
- Trial name
- NCT03419871
- Testing
- Monitoring Sleep, stress biomarkers
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Eczema, Infantile, Eczema
Seal, Stopping Eczema and Allergy Study
This is a randomized, controlled trial designed for children who are have already developed atopic dermatitis (AD or eczema) by 12 weeks of age.
- Conditions
- Eczema, Infantile, Eczema, Atopic Dermatitis Eczema, Atopic Dermatitis
- Trial name
- NCT03742414
- Testing
- Tri-lipid skin barrier cream (Epiceram), Fluticasone propionate Cream 0.05%, Standard of Care
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 398 people
- Sponsor
- Kari Nadeau, MD, PhD
Lymphoma
Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00392834
- Testing
- filgrastim, pegfilgrastim, rituximab
- Where
- 13 sites in United States
- Volunteers
- 34 people
- Sponsor
- AIDS Malignancy Consortium
Peri-Implantitis
Effect of Customized Versus Stock Healing Abutments on Peri-Implant Soft Tissue
The aim of this study is to compare customized and stock healing abutments for peri-implant soft tissue changes after immediate implant placement in the maxillary esthetic zone, and to assess the feasibility of a full-scale trial.
- Trial name
- NCT07906899
- Testing
- implant placement with a customized healing abutment, implant placement with a prefabricated (stock) healing abutment.
- Volunteers
- 28 people
- Sponsor
- Cairo University
Chronic Adrenal Insufficiency
A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)
As a post-approval requirement of the European Medicines Agency, this European patient post authorization safety study is an observational study being conducted to monitor the safety of long-term treatment with Plenadren and…
- Trial name
- NCT01661387
- Where
- 24 sites in Germany, Italy and 3 more
- Volunteers
- 3,258 people
- Sponsor
- Shire
Intraoperative, Venous Congestion
Venous Congestion And Delirium After Cardiac Surgery
Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery.
- Conditions
- Intraoperative, Venous Congestion, Postoperative Delirium (POD), Cardiac Surgery
- Trial name
- NCT07285187
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POD assessments
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhuan Zhang
Scar, Hydrocortisone
Effect of Hydrocortisone Iontophoresis Versus Hydrocortisone Phonophoresis On Post Surgical Scar
The purpose of this study will be to compare the effect of hydrocortisone iontophoresis and hydrocortisone phonophoresis on the treatment of surgical scar and overall scar appearance.
- Conditions
- Scar, Hydrocortisone, Iontophoresis, Phonophoresis
- Trial name
- NCT05293652
- Testing
- Iontophoresis, Phonophoresis, traditional PT program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Horus University
Stress, Physiological
Cortisol Measurement During Intravenous Access With a Medical Clown
The purpose of this study is to determine whether the presence of a medical clown in a pediatric emergency department procedure room would reduce children's anxiety.
- Trial name
- NCT02168998
- Testing
- Clown
- Where
- Israel
- Volunteers
- 55 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease, Coping Skills
Expressive Writing for Individuals With Parkinson's Disease and Their Caregivers
This randomized, controlled trial (RCT) evaluates the benefits of expressive compared to neutral writing in individuals with Parkinson's Disease and their support persons.
- Trial name
- PDEWS (NCT02217735)
- Testing
- Writing Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
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