Clinical trials: Hydrocortisone
Fear of Spiders, Acute Stress Reaction
The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes
This clinical trial aims to evaluate the nature and duration of effects of three FDA-approved medications (propranolol and hydrocortisone) on military-relevant cognitive, emotional, and motor performance following an exposure to…
- Trial name
- NCT06982183
- Testing
- Propranolol, Hydrocortisone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Down Syndrome, Acute Lymphoblastic Leukemia
ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016
To evaluate the outcome of a prednisolone and low dose methotrexate based protocol in Down syndrome children with ALL (DS-ALL) in an Asia-wide study.
- Conditions
- Down Syndrome, Acute Lymphoblastic Leukemia, Childhood Cancer
- Trial name
- NCT03286634
- Testing
- Daunorubicin, Prednisolone, Vincristine
- Where
- 10 sites in Hong Kong, Japan and 4 more
- Volunteers
- 60 people
- Sponsor
- National Hospital Organization Nagoya Medical Center
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia
This phase I trial tests the safety, best dose, and effectiveness of revumenib given as maintenance therapy after standard hematopoietic stem cell transplant (HSCT) in patients with acute lymphoblastic leukemia, acute myeloid…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia, Childhood Acute Myeloid Leukemia
- Trial name
- NCT07498465
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Sponsor
- Children's Oncology Group
Adrenal Gland Disease
The ARISE Trial Compares Whether Giving Routine Steroid Replacement or Using Targeted Blood Tests to Guide Replacement Better Protects Certain Patients From Adrenal Insufficiency After the Removal of a Diseased Adrenal Gland.
Adrenalectomy is an operation to remove one of the adrenal glands. It is commonly performed to treat adrenal tumours or conditions that cause excess hormone production.
- Trial name
- ARISE (NCT07558135)
- Testing
- Empirical Hydrocortisone Protocol, Targeted Treatment Protocol
- Volunteers
- 96 people
- Sponsor
- King's College Hospital NHS Trust
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005)
The purpose of this study is to assess the efficacy and safety of opevesostat in the treatment of Japanese men with metastatic castration-resistant prostate cancer (mCRPC) previously treated with Next Generation Hormonal Agent…
- Trial name
- NCT06104449
- Testing
- Opevesostat, Dexamethasone, Fludrocortisone acetate
- Where
- 3 sites in Japan
- Volunteers
- 7 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia
The overall aim of this study is to determine if epigenetic priming with a DNA methyltransferase inhibitor (DMTi) prior to chemotherapy blocks is tolerable and carries evidence of a clinical efficacy signal as determined by…
- Trial name
- NCT03164057
- Testing
- Azacitidine, Decitabine, Cytarabine
- Where
- 10 sites in United States
- Volunteers
- 206 people
- Sponsor
- St. Jude Children's Research Hospital
Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery
Sore Throat After Open Neck Elective Surgery
This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough…
- Trial name
- STONES (NCT07124650)
- Testing
- Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine
- Where
- Russia
- Volunteers
- 764 people
- Sponsor
- Saint Petersburg State University, Russia
Prostate Cancer
177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer
The purpose of this study is to test the effectiveness of the experimental drug, 177Lu-J591 in combination with ketoconazole and hydrocortisone against prostate cancer.
- Trial name
- NCT00859781
- Testing
- 177Lu-J591, Ketoconazole, Hydrocortisone
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- Weill Medical College of Cornell University
PTSD, Acute Stress Disorder
PTSD Prevention Using Oral Hydrocortisone
There is currently no evidence-based intervention for individuals exposed to trauma that is designed to aid recovery and prevent the development of post-traumatic stress disorder (PTSD).
- Conditions
- PTSD, Acute Stress Disorder, Trauma-related Stressor
- Trial name
- NCT04924166
- Testing
- Hydrocortisone
- Where
- 3 sites in United States, Israel
- Volunteers
- 201 people
- Sponsor
- Rachel Yehuda
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)
The primary objectives of this study are to evaluate the safety and tolerability of opevesostat in the treatment of male Chinese participants with metastatic castration-resistant prostate cancer (mCRPC) and to characterize the…
- Trial name
- NCT06136598
- Testing
- Opevesostat, Dexamethasone, Fludrocortisone
- Where
- 3 sites in China
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
Community Acquired Pneumonia (CAP)
Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP).
- Trial name
- NCT06892197
- Testing
- Methylprednisolone (drug), hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 1,600 people
- Sponsor
- Copenhagen Respiratory Research
Chronic Obstructive Pulmonary Disease (COPD)
Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT06892210
- Testing
- Methylprednisolone (drug), Hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen Respiratory Research
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Myelodysplastic Syndromes, de Novo, Myelodysplastic Syndromes, Secondary
Venetoclax Basket Trial for High Risk Hematologic Malignancies
This trial is evaluating the safety and tolerability of venetoclax with chemotherapy in pediatric and young adult patients with hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia derived…
- Conditions
- Myelodysplastic Syndromes, de Novo, Myelodysplastic Syndromes, Secondary, Myelodysplastic Syndromes, Previously Treated, Treatment-Related Acute Myeloid Leukemia
- Trial name
- NCT05292664
- Testing
- Venetoclax, Azacitidine, Cytarabine
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Andrew E. Place, MD
Septic Shock
Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock
The purpose of this study is to evaluate the efficacy and safety of the combination therapy of hydrocortisone and fludrocortisone among adult patients with septic shock.
- Trial name
- NCT07383103
- Testing
- Hydrocortisone plus Fludrocortisone, Standard care
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Northern Jiangsu People's Hospital
Pancreatitis, Pancreatitis, Acute
Corticosteroids to Treat Pancreatitis
This research is being done to determine if the administration of a short course of intravenous hydrocortisone, an anti-inflammatory medication, to patients with severe acute pancreatitis will improve their clinical outcomes and…
- Conditions
- Pancreatitis, Pancreatitis, Acute, Corticosteroid, Hydrocortisone
- Trial name
- CRISP (NCT05160506)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Lymphoblastic Leukemia
Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia
This trial is a limited multi-center, Phase II study to evaluate inotuzumab ozogamicin (Besponsa) in pediatric patients with MRD positive CD22-positive B-lymphoblastic leukemia (B-ALL).
- Trial name
- NCT03913559
- Testing
- Inotuzumab ozogamicin, Methotrexate, Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- St. Jude Children's Research Hospital
Opioid Use Disorder
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs.
- Trial name
- NCT04231708
- Testing
- Yohimbine + Hydrocortisone, Active rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Community Acquired Pneumonia
Community-Acquired Pneumonia : Evaluation of Corticosteroids
Mortality of severe Community-Acquired Pneumonia (CAP) has not declined over time and is between 25 and 30% in sub-groups of patients.
- Trial name
- CAPE_COD (NCT02517489)
- Testing
- Hydrocortisone
- Where
- 32 sites in France
- Volunteers
- 952 people
- Sponsor
- University Hospital, Tours