Clinical trials: Ibuprofen, completed
Acute Pain
Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction
The objective of this study is to evaluate the analgesic efficacy and safety of ADL5859 compared with placebo and an active control (ibuprofen) in subjects with acute dental pain after third molar extraction.
- Trial name
- NCT00993863
- Testing
- ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Postoperative Pain
Maxigesic® IV Phase 3 Exposure Study
The study aims to determine the tolerability of repeated doses of Maxigesic® IV over an extended period of exposure.
- Trial name
- NCT04005755
- Testing
- Maxigesic® IV
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 232 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Femoral Neuropathy
Femoral Neuropathy After Anterior Cruciate Ligament Reconstruction: Femoral Nerve Block vs Patient-controlled Analgesia (PCA)
Femoral neuropathy after anterior cruciate ligament reconstruction with femoral nerve block may be as high as 24% at 6 postoperative weeks when evaluated prospectively and systematically through a clinical neurological and an…
- Trial name
- NCT01321138
- Testing
- Femoral nerve block, PCA morphine
- Where
- Switzerland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy
Assessment of the Analgesic Effects of PF-06273340 in Healthy Volunteers Using Evoked Pain Endpoints
This study will examine the activity of 2 different doses of PF-06273340 on a panel of evoked pain tests carried out from 0.5 to 10 hours following oral dosing in healthy male subjects
- Trial name
- NCT02260947
- Testing
- PF-06273340, Pregabalin, Ibuprofen
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lower Extremity Problem, Surgery
Ibuprofen IV vs Acetaminophen IV for the Treatment of Pain Following Orthopaedic Low Extremity Surgery
This study aims to evaluate the efficacy of IV Ibuprofen versus IV Acetaminophen in the reduction of pain following orthopedic low extremity procedures
- Conditions
- Lower Extremity Problem, Surgery, Postoperative Pain
- Trial name
- NCT03771755
- Testing
- Ibuprofen, Acetaminophen
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Universitas Indonesia
Primary Dysmenorrhea
Diagnostic and Therapeutic Potential of Substance P/ NK1R Receptor in Primary Dysmenorrhea
Dysmenorrhea is characterized as excruciating menstrual cramps of uterine origin and is one of the most prevalent gynecological illnesses.
- Trial name
- NCT06317064
- Testing
- Ibuprofen and Aprepitant
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lahore Medical Research Center, LLP
Pain, Acute, Anxiety
Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office
This study seeks to determine if music reduces pain and anxiety in comparison to routine pain control measures alone during insertion of intrauterine contraceptive devices (Mirena, Paragard)
- Trial name
- MIUD (NCT05068245)
- Testing
- Preselected classical music
- Where
- 2 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Muscle Soreness
Ibuprofen Versus Placebo For Muscle Soreness
The study will assess the sensitivity of the Delayed Onset Muscle Soreness Model by comparing the safety and efficacy of oral ibuprofen to placebo over 24 hours.
- Trial name
- NCT03228992
- Testing
- Ibuprofen 400 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jean Brown Research
Periodontal Disease, Nutrient Intake
Effectiveness NutriDent4Mom to Improve Nutrient Intake, Diet Quality, and Periodontal Health Status of Pregnant Women
The goal of this two-arm, parallel-group cluster randomized controlled trial was to assess the effectiveness of a healthcare mobile application prototype (NutriDent4Mom) in improving nutrient intake, diet quality and periodontal…
- Conditions
- Periodontal Disease, Nutrient Intake, Diet Quality
- Trial name
- NCT07247019
- Testing
- Mobile Application Prototype, Health education
- Where
- Malaysia
- Volunteers
- 264 people
- Sponsor
- NORKHAFIZAH SADDKI
Pain
Caldolor Versus Caldolor Plus OFIRMEV in Total Knee or Hip Arthroplasty Surgeries
The objective of this study is to compare the effectiveness and of perioperative use of Caldolor alone and in combination with OFIRMEV in total knee or hip arthroplasty procedures.
- Trial name
- NCT01773005
- Testing
- Ofirmev, Caldolor
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Anita Gupta
Healthy
A Four-Period, Four-Treatment, Four-Way Relative Bioavailability Study of CL-108 Under Fed and Fasted Conditions
This study will compare the relative bioavailability of hydrocodone, acetaminophen, and promethazine in CL-108 (hydrocodone 7.5mg/ acetaminophen 325 mg/ promethazine 12.5 mg) manufactured by Charleston Laboratories, Inc.
- Trial name
- NCT02465866
- Testing
- CL-108, Vicoprofen, Ultracet
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charleston Laboratories, Inc
Post Operative Dental Pain
Study of Acetaminophen (ACM) in Post-operative Dental Pain
This is a Dental Pain Study which will evaluate the analgesic onset, efficacy and safety of 1000 mg acetaminophen as two Test acetaminophen 500 mg tablets, compared with commercial products of acetaminophen 1000 mg administered…
- Trial name
- NCT02735122
- Testing
- acetaminophen Tablet, acetaminophen Caplet, ibuprofen Liquid-filled capsule
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Pain, Acute, Hip Arthropathy
Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty
Multimodal pain management is essential for recovery after surgery, aiming to target different pain mechanisms to minimize opioid usage and opioid-related adverse effects.
- Conditions
- Pain, Acute, Hip Arthropathy, Analgesia, Postoperative Pain
- Trial name
- RECIPE (NCT04123873)
- Testing
- Paracetamol, Ibuprofen, Dexamethasone
- Where
- 7 sites in Denmark
- Volunteers
- 1,060 people
- Sponsor
- Naestved Hospital
Laparoscopic Cholecystectomy
Effect of Preemptive Ibuprofen and Dexketoprofen in Patients Undergoing Laparoscopic Cholecystectomy
The primary aim of this study is to investigate the effects of preventive ibuprofen and dexketoprofen on postoperative opioid requirement in patients undergoing elective laparoscopic cholecystectomy.
- Trial name
- NCT03607266
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Ductus Arteriosus, Patent
Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants
The purpose of this study is to determine if adding paracetamol to ibuprofen is superior to ibuprofen only for treatment of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- NCT02002741
- Testing
- Paracetamol
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Rambam Health Care Campus
Chronic Low Back Pain
A Double Blind Placebo Study to Determine the Effectiveness of Theramine on the Management of Chronic Back Pain
This research protocol will compare Theramine to a non-steroidal anti-inflammatory drug (NSAID) in the treatment of chronic back pain.
- Trial name
- NCT01490905
- Testing
- Theramine (A medical food), Theraprofen, Ibuprofen
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Targeted Medical Pharma
Shoulder Pain
Post-Operative Pain Control Following Shoulder Surgery
This study will evaluate overall opioid and non-narcotic analgesic use following surgical treatment for shoulder pathology, and recommend evidence based guidelines for standardized postoperative pain management.
- Trial name
- NCT04622839
- Testing
- Tylenol and NSAIDS (Ibuprofen, diclofenac)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Johns Hopkins University
Pain, Acute
Periprostatic Nerve Block vs. Intravenous Ibuprofen for Pain Management During Transrectal Prostate Biopsy
This study aimed to compare the efficacy of intravenous ibuprofen with peri-prostatic nerve block in pain control during prostate biopsy and to investigate factors influencing pain scores.
- Trial name
- NCT06737939
- Testing
- intravenous ibuprofen, periprostatic nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- University of Gaziantep
Ankle Fracture
NSAIDS Versus Opioids in Acute SER II Ankle Fractures
This study is being conducted to evaluate whether NSAIDS are more or less effective in bone healing than opioids in acute fracture pain.
- Trial name
- NCT02373254
- Testing
- Ibuprofen, Acetaminophen/hydrocodone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Sleep
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine
The objectives of the study are to evaluate the analgesic and hypnotic efficacy of naproxen sodium and diphenhydramine combination when compared to naproxen sodium, diphenhydramine, and an ibuprofen and diphenhydramine combination
- Trial name
- NCT01118273
- Testing
- Naproxen Sodium 440 mg (BAYH6689) / DPH 50mg, Naproxen Sodium 440 mg (BAYH6689), Naproxen Sodium 220 mg (BAYH6689) / DPH 50mg
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Bayer