Clinical trials: Ibuprofen
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Leg Ulcers
Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers
The objective of this open label extension study (extension to study DK143WS) is to evaluate the safety of Biatain Ibu during 6 -12 weeks of exposure and during a 40 - 46 weeks safety follow-up period.
- Trial name
- NCT00628004
- Testing
- Biatain Ibu, Local best practice
- Where
- 5 sites in Denmark, Germany and 1 more
- Volunteers
- 93 people
- Sponsor
- Coloplast A/S
Analgesia
Self-Selection and Actual Use Trial of Ibuprofen 600 mg Immediate Release/Extended Caplet
A self-selection and actual use trial to evaluate the extent to which consumers will appropriately select and use the 600 mg immediate release/extended release caplets and comply with dosing instructions.
- Trial name
- NCT01789606
- Testing
- Ibuprofen 600 mg Immediate Release/Extended Release Caplet
- Where
- 18 sites in United States
- Volunteers
- 1,083 people, healthy volunteers welcome
- Sponsor
- Pfizer
Epilepsy, Epilepsies, Partial
Treating Postictal Symptoms Using Ibuprofen and Nifedipine
This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy.
- Trial name
- NCT03949478
- Testing
- Ibuprofen, Nifedipine
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Low Back Pain
Efficacy of Metamizole Versus Ibuprofen and a Short Educational Intervention Versus Standard Care in Acute Low Back Pain
The EMISI trial is a randomized, double blind, controlled trial (RCT) using a factorial design in patients with a new low back pain episode.
- Trial name
- EMISI (NCT04111315)
- Testing
- Metamizole Sodium, Ibuprofen 600 mg, Patient education
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Pediatric Disorder
Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen?
To examine the difference in pain control in the pediatric general surgery population alternating acetaminophen and Ibuprofen q 3 hours vs giving them simultaneous combination therapy around the clock.
- Trial name
- NCT06505148
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor Research Institute
Endodontic Disease
Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth
The patients will be randomly assigned into two equal groups Group : OneShape Group: ProtaperNext Endodontics procedure steps: Patient will be anesthetized by using infiltration local anesthesia or nerve block according to the…
- Trial name
- RCT2019 (NCT04200638)
- Testing
- ProTaper Next
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Cancer Pain, Cancer Palliative Care
Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management
The investigators investigate the efficacy of non-opioid analgesics compared to placebo together with opioid therapy for cancer pain management.
- Trial name
- NoDoubt (NCT07682558)
- Testing
- Metamizole, Ibuprofen
- Where
- Switzerland
- Volunteers
- 318 people
- Sponsor
- University Hospital, Basel, Switzerland
Orthodontic Pain
Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
The purpose of this research study is to compare pain control effectiveness of two medicines and a placebo (a dummy pill that does not contain any pain relieving medication) to see which one works better at preventing pain when…
- Trial name
- NCT00484744
- Testing
- Acetaminophen, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Postoperative Pain
Phase 2 Herniorrhaphy Study for Opioid Elimination
This is a Phase 2, open-label study in subjects undergoing unilateral open inguinal herniorrhaphy.
- Trial name
- NCT03695367
- Testing
- HTX-011, Luer lock applicator, Vial access device
- Where
- 5 sites in United States
- Volunteers
- 63 people
- Sponsor
- Heron Therapeutics
Symptomatic Irreversible Pulpitis
Effect of Cryotherapy Versus Post-operative Ibuprofen Medication on Post-operative Pain in Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis
Evaluation of the effect of cryotherapy versus post-operative ibuprofen medication on post-operative pain in mandibular molar teeth with symptomatic irreversible pulpitis .
- Trial name
- NCT05341999
- Testing
- cold saline (cryotherapy), Ibuprofen 400 mg, Final irrigation with normal saline
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Delayed Onset Muscle Soreness
Dosing Interval Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness
This is a Phase 2, prospective, randomized, dual-center, double-blind, placebo-controlled, parallel-group study designed to determine the dosing interval, efficacy and safety of SST-0225 (5.4 grams, applied up to 6 times in 24…
- Trial name
- DIS DOMS (NCT02339129)
- Testing
- SST-0225
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Strategic Science & Technologies, LLC
Postoperative Pain
Outcomes for Anesthesiologist-Led Care of Analgesic Protocol in Anorectal Surgery
This will be an open, prospective, parallel-group, randomized controlled trial. Patients scheduled for complex anorectal surgery under general anesthesia will be enrolled, and the perioperative analgesia mode led by…
- Trial name
- NCT06015165
- Testing
- Analgesia plan for Anes. Group, Analgesia plan for Surg. Group, Multi-modal analgesia during the surgery
- Where
- 2 sites in China
- Volunteers
- 216 people
- Sponsor
- China-Japan Friendship Hospital
Pelvic Pain
Efficacy of the Photobiomodulation on the Pelvi-perineal Pain in Immediate Post-partum Situation
Photobiomodulation (PBM), evaluated in this study, will be delivered by a CE marked class IIa medical device (MILTA technology), composed of a panel that gathers 18 emitters.
- Trial name
- NCT04896034
- Testing
- MILTA Device, " control 1 " fake MILTA device
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Elsan
Chronic Kidney Disease, Pediatric Urology
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney…
- Trial name
- NCT06860711
- Testing
- NSAIDs
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Colorado, Denver
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypertension
NSAID Use in Postpartum Hypertensive Women
Women who have the diagnosis of hypertension (pre-pregnancy and pregnancy induced) and deliver an infant via vaginal delivery will be placed into two groups in the postpartum period.
- Trial name
- NCT02902172
- Testing
- Acetaminophen, NSAID
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts