Clinical trials: Ibuprofen, completed
Osteoarthritis
Osteoarthritis Topical Treatment
This is a phase 2a clinical trial performed to evaluate the efficacy of a topical treatment of ibuprofen compared to the use of a placebo topical treatment. A multi-center, double-blinded, randomized placebo controlled study.
- Trial name
- ANTIPAIN (NCT01496326)
- Testing
- Ibuprofen
- Where
- 5 sites in Switzerland
- Volunteers
- 75 people
- Sponsor
- BioChemics, Inc.
Pain, Post Partum Depression
Vaginal Postpartum Pain Management Protocol Comparison
Untreated postpartum pain has been associated with increased risk of opioid use, postpartum depression and development of persistent pain.
- Conditions
- Pain, Post Partum Depression, Opioid Use, Breast Feeding
- Trial name
- NCT04087317
- Testing
- Paracetamol 1000 Mg Oral Tablet, Ibuprofen 400Mg Tab, Ibuprofen 400 mg
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Primary Dysmenorrhea
Moxibustion for Primary Dysmenorrhea
Hypothesis: Moxibustion is effective for managing primary dysmenorrhea. Aim: To attest the effectiveness and safety of moxibustion for primary dysmenorrhea. Design: A randomized controlled trial.
- Trial name
- NCT01972906
- Testing
- moxibustion, Ibuprofen Sustained Release Capsules
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Pain, Postoperative
A Trial to Compare the Duration of Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Ibuprofen Tablets in Postsurgical Dental Pain
To compare the duration of analgesic efficacy as determined by the time to rescue medication of a single oral dose of naproxen sodium 440 mg (2 x 220 mg tablets) relative to ibuprofen 400 mg (2 x 200 mg tablets) and placebo over…
- Trial name
- NCT03404206
- Testing
- Naproxen Sodium (Aleve, BAY117031), Ibuprofen (Advil)
- Where
- United States
- Volunteers
- 387 people
- Sponsor
- Bayer
Reduction of Small Intestinal Ulceration Risk
The Effect of a Probiotic Strain on Ibuprofen-induced GI Damage
To investigate if a daily dose of minimum 15 billion CFU of Bif195 reduces the risk of small-intestinal tissue damage in an Ibuprofen challenge model as assessed by video capsule endoscopy in a healthy US population.
- Trial name
- PIP-I (NCT04447924)
- Testing
- Bif195
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
High Altitude
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude
Ibuprofen is often taken by travelers to high altitude to treat the symptoms of acute mountain sickness such as headache and malaise.
- Trial name
- NCT02233582
- Testing
- Ibuprofen, Sugar pill
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain Management
Comparison of IV Nalbuphine Versus Ibuprofen for Postoperative Pain Control in Cesarean Section
The local data is insufficient to directly compare IV nalbuphine versus ibuprofen among people in this region. The findings of this study would add to the existing data and would be helpful for health providers to opt for a…
- Trial name
- NCT06594224
- Testing
- Ibuprofen, Nalbuphine
- Where
- 2 sites in Pakistan
- Volunteers
- 80 people
- Sponsor
- Muhammad Aamir Latif
Pre-emptive Analgesia in Different Psycho-emotional Status Patients
Pre-emptive Analgesia Effect in Different Psycho-emotional Status Patients During Lower Third Molar Surgical Extractions
To increase the effectiveness of pain control, it is recommended to use drugs before the pain onset, therefore the pre-emptive analgesia method is considered as a method, which allows decreasing the post-operative pain to…
- Trial name
- NCT04202224
- Testing
- Ibuprofen 400 mg and Acetaminophen 500 mg, Glucose, No drug
- Where
- Lithuania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Pain
Evaluation of the Efficacy of Novel Ibuprofen Acetaminophen Combination Formulations in the Treatment of Post-surgical Dental Pain
This study will determine the overall analgesic efficacy of three different fixed dose ibuprofen plus acetaminophen formulations compared to ibuprofen alone and to placebo.
- Trial name
- NCT01559259
- Testing
- Ibuprofen/acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Pfizer
Immune System and Related Disorders
Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation
The purpose of this clinical investigation is to evaluate the efficacy and immunologic effects of a non-pharmacological exercise intervention (push-ups) compared to an oral NSAID (ibuprofen) and an oral placebo to decrease local…
- Trial name
- NLP (NCT02807623)
- Testing
- Ibuprofen, Compound Exercise of Push-ups
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Womack Army Medical Center
Patent Ductus Arteriosus
Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA
The purpose of this study is to determine the safety and effectiveness of ibuprofen l-lysine iv in premature infants in the early treatment of Patent Ductus Arteriosus.
- Trial name
- NCT00440804
- Testing
- ibuprofen l-lysine iv solution (NeoProfen (R) )
- Sponsor
- Farmacon
Postoperative Pain, Opioid Use
STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial
Overprescribing opioids is considered a major contributor to the opioid crisis. Hill et al. demonstrated that within a general surgery practice, over 70% of the prescribed opioid pills were never taken.
- Conditions
- Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
- Trial name
- STOP-PAIN (NCT04491617)
- Testing
- Standard opioid prescribing, Restrictive opioid prescribing
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- The Cleveland Clinic
Pain, Acute, Hip Arthropathy
Safety of Ibuprofen After Major Orthopaedic Surgeries
Safety of an eight-day treatment with ibuprofen after primary hip and knee arthroplasties.
- Conditions
- Pain, Acute, Hip Arthropathy, Knee Arthropathy, Safety Issues
- Trial name
- PERISAFE (NCT05575700)
- Testing
- Ibuprofen
- Where
- 11 sites in Denmark
- Volunteers
- 2,904 people
- Sponsor
- Naestved Hospital
KNEE OSTEOARTHRITIS
Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
This study is a randomized, double-blind clinical trial in a Chinese population.
- Trial name
- NCT03691818
- Testing
- X0002 Spray, Ibuprofen Tablet
- Where
- China
- Volunteers
- 353 people
- Sponsor
- Tianjin XinChen-Techfields Pharma Co., LTD.
Mosquito Bite
Evaluation of Anti-inflammatories in the Reduction of Bite Reactions
The purpose of this study is to evaluate two separate antiinflammatory products for the relief of symptoms through suppression of the immunological and inflammatory response following a mosquito bite.
- Trial name
- NCT01452997
- Testing
- NSAI treatment, Steroid treatment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Symptomatic Irreversible Pulpitis
Evaluating the Combined Effect of Oral Premedications on Inferior Alveolar Nerve Block Effectiveness
This clinical study investigates whether the combination of ibuprofen and serratiopeptidase as oral premedication can enhance the effectiveness of the inferior alveolar nerve block (IANB) in patients with symptomatic irreversible…
- Trial name
- NCT07146997
- Testing
- Patients will receive ibuprofen (400-600 mg, standard therapeutic dose) orally, 1 hour prior to IANB, Group III - Serratiopeptidase Group, Group IV - Combination Group (Ibuprofen and Serratiopeptidase)
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Zahoor khan
Pain
Hydrocodone For Pain Control in First Trimester Surgical Abortion
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.
- Trial name
- NCT01330459
- Testing
- Hydrocodone/acetaminophen, Ibuprofen, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Elizabeth Micks
Sleep
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine
The objectives of the study are to evaluate the analgesic and hypnotic efficacy of naproxen sodium and diphenhydramine combination when compared to naproxen sodium, diphenhydramine, and an ibuprofen and diphenhydramine combination
- Trial name
- NCT01118273
- Testing
- Naproxen Sodium 440 mg (BAYH6689) / DPH 50mg, Naproxen Sodium 440 mg (BAYH6689), Naproxen Sodium 220 mg (BAYH6689) / DPH 50mg
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Bayer
Chronic Pain
To Evaluate the Food Effect and the Absorption Profile of Ibuprofen Modified-Release Tablets 800 mg
An open-label, randomized, 3-way crossover study to evaluate the pharmacokinetics of investigational product "Ibuprofen Modified-Release Tablets 800 mg" in comparison to the reference standard "Ibuprofen Regular-Release Tablets…
- Trial name
- NCT05329454
- Testing
- Ibuprofen Tablets
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Overseas Pharmaceuticals, Ltd.
Back Pain, Scoliosis
Back Pain and Spinal Manipulation in Adolescent Scoliosis
Adolescent idiopathic scoliosis (AIS) affects 2 - 3% of children and adolescents older than 10 years and is of unknown cause. It was initially thought that occurrences of back pain (BP) were similar to the one encounter in…
- Trial name
- NCT02609009
- Testing
- Spinal Manipulation Therapy, Usual Medical Care
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital