Clinical trials: Ibuprofen, completed
Osteoarthritis
Osteoarthritis Topical Treatment
This is a phase 2a clinical trial performed to evaluate the efficacy of a topical treatment of ibuprofen compared to the use of a placebo topical treatment. A multi-center, double-blinded, randomized placebo controlled study.
- Trial name
- ANTIPAIN (NCT01496326)
- Testing
- Ibuprofen
- Where
- 5 sites in Switzerland
- Volunteers
- 75 people
- Sponsor
- BioChemics, Inc.
Postoperative Pain
Phase 2 Herniorrhaphy Study for Opioid Elimination
This is a Phase 2, open-label study in subjects undergoing unilateral open inguinal herniorrhaphy.
- Trial name
- NCT03695367
- Testing
- HTX-011, Luer lock applicator, Vial access device
- Where
- 5 sites in United States
- Volunteers
- 63 people
- Sponsor
- Heron Therapeutics
Mental Health Issue, Physical Health
Mental Health and Symptoms of Energy Deficiency (REDs) in Young Biathletes
Participation in weight-sensitive sports has been identified as a significant risk factor for low energy availability (LEA), relative energy deficiency in sport (REDs), and eating disorders.
- Trial name
- NCT06487260
- Where
- 2 sites in Norway
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Lateral Ankle Sprain, Ankle Injuries
PRICE vs PEACE and LOVE in Adolescent Lateral Ankle Sprain Rehabilitation
This study compared two early management strategies for adolescents with first-time lateral ankle sprain: the traditional PRICE protocol (Protection, Rest, Ice, Compression, Elevation) combined with non-steroidal…
- Conditions
- Lateral Ankle Sprain, Ankle Injuries, Sprain of Lateral Ligament, Rupture of Ligaments at Ankle and Foot Level
- Trial name
- NCT07287020
- Testing
- PRICE + NSAIDs protocol, PEACE and LOVE protocol
- Where
- Lithuania
- Volunteers
- 76 people
- Sponsor
- Lithuanian University of Health Sciences
Healthy
pK of a Novel 200 mg Ibuprofen Medicated Plaster
This is a Phase I study of the pharmacokinetics of a novel 200 mg Ibuprofen Medicated Plaster. The study will be conducted as a monocentric, open, randomised, single and multiple-dose, two-period, crossover trial in healthy…
- Trial name
- NCT03694587
- Testing
- Ibuprofen 200 mg TEPI Medicated Plaster, Aktren® 200 mg überzogene Tabletten (Ibuprofen)
- Where
- Bulgaria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medherant Ltd
Laparoscopic Cholecystectomy, Pain Management
Recto-Intercostal Fascial Plane (RIFP) Block in Laparoscopic Cholecystectomy Patients
Ultrasound-guided Recto-Intercostal Fascial Plane (RIFP) Block is performed by injecting local anesthetic deep between the 7th rib and the costochondral aspect of the rectus muscle.
- Conditions
- Laparoscopic Cholecystectomy, Pain Management, Plane Block, Acute Pain
- Trial name
- RIFPB (NCT06768593)
- Testing
- RIFP Block, Postoperative pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Istanbul Medipol University Hospital
Cognitive Impairment, Malignant Neoplasm
Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer
This randomized phase II trial studies how well low-dose ibuprofen in improving cognitive impairment in patients with cancer. Anti-inflammatory agents, such as ibuprofen, may slow the decline of cognitive processes and diseases…
- Trial name
- NCT03186638
- Testing
- Ibuprofen, Questionnaire Administration
- Where
- 169 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Rochester NCORP Research Base
Gynecologic Surgery
A Fast-track Versus Conventional Recovery Protocol in Laparoscopic Hysterctomy
Factors affecting to length of hospital stay after fast-track recovery program in laparoscopic hysterectomy compared to conventional recovery program
- Trial name
- NCT03828981
- Testing
- fast-track recovery program
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Relapsing Multiple Sclerosis
Transition to Rebif New Formulation
To assess patient satisfaction with respect to the incidence of flu-like symptoms (FLS) in patients with multiple sclerosis transitioned from current Rebif (subcutaneously injected interferon beta-1a, 44 mcg three-times-weekly)…
- Trial name
- TRANSFER (NCT00619307)
- Testing
- Rebif New Formulation + prophylactic Ibuprofen, Rebif New Formulation + ibuprofen PRN
- Where
- 2 sites in France, Germany
- Volunteers
- 117 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Abortion, Induced, Cervical Preparation
Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial
Women having abortion procedures between 15 weeks 0 days and 23 weeks 6 days gestational age on the day of their procedure commonly have dilators placed in their cervix overnight before the abortion procedure.
- Conditions
- Abortion, Induced, Cervical Preparation, Pain
- Trial name
- GABA (NCT03080493)
- Testing
- Gabapentin 600mg, acetaminophen/codeine and ibuprofen
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of California, Davis
Pain, Postoperative
Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction
Postoperative pain is common and particularly outpatients may experience unsatisfactory pain relief. This randomized, double-blind, crossover study of postoperative pain in outpatients undergoing split-mouth, third lower molar…
- Trial name
- NovIbu (NCT02686021)
- Testing
- Metamizole and Ibuprofen
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Basel, Switzerland
Bariatric Surgery Candidate, Obesity, Morbid
Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.
- Trial name
- NCT02778958
- Testing
- paracetamol, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
Migraine
Acetaminophen and Ibuprofen With and Without Magnesium and Primary Migraine in Childhood
Aim: The purpose of this study was to evaluate both the effects of ibuprofen and/or acetaminophen for the acute treatment of primary migraine in children in or out prophylactic treatment with magnesium.
- Trial name
- NCT01756209
- Testing
- Magnesium 400Mg, Ibuprofen 10 mg/kg, acetaminophen 15 mg/kg
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Catanzaro
Surgery
Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain
The purpose of this placebo controlled clinical trial is to evaluate the dose response relationship of ibuprofen in doses from 400 mg to 800 mg and paracetamol (acetaminophen)in doses from 500 mg to 1000 mg compared with…
- Trial name
- NCT00699114
- Testing
- Ibuprofen 400 mg, Ibuprofen 600 mg, Ibuprofen 800 mg
- Where
- Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Pain
A Bioequivalence Study of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) Versus Advil Dual Action Caplets (125 mg/250 mg) and Bioavailability Assessment of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) and Advil Liqui-Gels (200 mg) in Healthy Adult Subjects
The primary purpose of this study is to demonstrate the bioequivalence of new formulation Advil Dual Action (ADA) liquid filled capsules (Test) compared to the currently marketed ADA Caplet (Reference) under fasted conditions and…
- Trial name
- NCT06802185
- Testing
- ADA Liquid Filled Capsules (Test Product), ADA Caplets (Reference Product), Advil Liqui-gels (Reference Product)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- HALEON
Pain
Trial of Caldolor for Treatment of Pain in Post-Operative Adult Patients
The primary objective of this study of Caldolor (IV ibuprofen) administered to post-operative hospitalized adult patients every 6 hours for 48 hours is to determine the efficacy of Caldolor compared to placebo for the treatment…
- Trial name
- NCT00225732
- Testing
- Intravenous ibuprofen
- Where
- 13 sites in United States, Australia
- Volunteers
- 319 people
- Sponsor
- Cumberland Pharmaceuticals
Recession, Gingival
Long-term Outcomes of Tunnel Technique
Few studies evaluate the outcomes beyond 1 year follow up for gingival recessions treatments using the tunnel technique in combination with connective tissue graft.
- Trial name
- NCT04016493
- Testing
- Connective tissue graft
- Volunteers
- 40 people
- Sponsor
- University of Liege
Pregnancy Related
Enhanced Recovery After Surgery for Emergency Caesarean Deliveries
Caesarean section (CS) constitutes a large proportion of the total surgical volume in low-income countries. This rate comes with challenges including surgical complications, shortage of beds, and consequently long waiting time…
- Trial name
- ERAS-Mbarara (NCT03518463)
- Testing
- Enhanced recovery after surgery (ERAS)
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- Mbarara University of Science and Technology
Carpal Tunnel Syndrome
Pain Reduction Produced by Different Treatments in Carpal Tunnel Syndrome
Pain reduction effects of the median nerve neural mobilization technique (a physiotherapy treatment) will be compared to those produced by a pharmaceutical treatment and the absence of treatment, in subjects who suffer carpal…
- Trial name
- NCT04119739
- Testing
- Median nerve neural mobilization, Ibuprofen Arginine
- Where
- Venezuela
- Volunteers
- 117 people
- Sponsor
- Francisco Unda Solano
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital