Clinical trials: Infliximab
Ulcerative Colitis
Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe…
- Trial name
- MASCC (NCT03669822)
- Testing
- Standard of care
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Johns Hopkins University
Inflammatory Bowel Disease, Crohn's Disease
The Impact of 6MP Metabolite Levels on Infliximab Pharmacokinetics and Anti-infliximab Antibodies in Crohn's Disease
In this research proposal, the investigators will focus on methods to optimize the therapeutic response to anti-TNF antibodies, by determining a correlation of 6-mp metabolite levels with IFX trough levels, anti-IFX antibody…
- Trial name
- NCT02453607
- Testing
- Infliximab, thiopurine
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Ernest Seidman
Inflammatory Bowel Disease
Precision IFX: Using a Dashboard to Individualize Infliximab Dosage
The introduction of infliximab (IFX) and other monoclonal antibodies (MAbs) targeting tumor necrosis factor (TNF) was a major advancement in the management of inflammatory bowel disease (IBD).
- Trial name
- NCT02624037
- Testing
- Individualized Dosage Precision IFX Dashboard
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rheumatoid Arthritis
The Effects of a 16-Week Individualized, Intensive Strength Training Program in Patients With Rheumatoid Arthritis
To assess the effects of a 16-week individualized, intensive strength training program in patients with rheumatoid arthritis. Primary and secondary outcomes include: strength and body composition, function, disease activity…
- Trial name
- NCT00327275
- Testing
- strength training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Crohn Disease
Infliximab Blood Test in Crohn's Disease
Ano-perineal lesions are the first signs of Crohn's disease in 1/3 to 1/2 of cases. They are most often associated with a poor prognosis of the disease and their management is complex and difficult because of the dilapidated and…
- Trial name
- NCT03964883
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Obesity, Insulin Resistance
Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity
The aim of the study is to test whether neutralizing TNF-alpha with infliximab affects insulin resistance and phenotypical manifestations of the metabolic syndrome as fasting plasma insulin, total body fat, plasma lipid profile…
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00636142
- Testing
- Infliximab
- Where
- Austria
- Volunteers
- 9 people
- Sponsor
- Medical University of Graz
Rheumatoid Arthritis
Clinical Comparative Study to Evaluate the Efficacy and Safety of Recombinant Anti-TNF-alpha Antibodies for Injection
This study compares the similarity of the proportion of subjects who achieved ACR20 at week 30 in the two groups.
- Trial name
- NCT04178850
- Testing
- GB242, Infliximab
- Where
- China
- Volunteers
- 568 people
- Sponsor
- Genor Biopharma Co., Ltd.
Rheumatoid Arthritis
Study of Etanercept in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Adalimumab or Infliximab Plus Methotrexate
The first 12 weeks of this study will compare the efficacy of etanercept 50 mg once-weekly to placebo in subjects with rheumatoid arthritis who have not responded well to infliximab or adalimumab plus methotrexate.
- Trial name
- SERUM (NCT01783015)
- Testing
- Etanercept
- Where
- 15 sites in Australia, Belgium and 5 more
- Volunteers
- 16 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy
More than half of rheumatoid arthritis (RA) patients complain of sleep disturbance and this cardinal complaint is associated with fatigue, pain, and depressed mood in patient with chronic inflammatory disorder.
- Trial name
- NCT00948610
- Testing
- Remicade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles