Clinical trials: Insulin, completed
Diabetes After Total Pancreatectomy
The Effect of Insulin-induced Hypoglycaemia on Gut-derived Glucagon Secretion (Px-Hypo)
The overall objective of this study is to investigate whether hypoglycaemia (the most potent stimulus of pancreatic glucagon secretion) affects the secretion of gut-derived glucagon in totally pancreatectomized patients.
- Trial name
- NCT04064203
- Testing
- Oral glucose tolerance test, Clamp experiment
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Breast Cancer, Insulin Resistance
Insulin Resistance and Breast Cancer
This study will characterize risk factors associated with breast cancer development in some patients. In particular, it will examine the role of insulin in breast cancer in patients with and without a family history of the…
- Trial name
- NCT00304941
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type I Diabetes Mellitus
Clinical Trial of Efficacy and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus
The purpose of this study is: to assess clinical efficacy of Subetta in the combined treatment of type I diabetes mellitus; to assess safety of Subetta in the combined treatment of type I diabetes mellitus.
- Trial name
- NCT01868594
- Testing
- Subetta
- Where
- 15 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Materia Medica Holding
Diabetes, Diabetes Mellitus, Type 1
Examining the Long-term Safety of Insulin Aspart When Used as a Part of the Treatment for Type 1 Diabetes
This trial is conducted in Europe and Asia. The aim of this clinical trial is to investigate the long-term safety of insulin aspart in the management of type 1 diabetes. An extension to the ANA/DCD/065 trial
- Trial name
- NCT00832182
- Testing
- insulin aspart, insulin NPH
- Where
- 10 sites in Croatia, Czechia and 3 more
- Volunteers
- 75 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Anti-Interleukin-1 in Diabetes Action
A draw trial of the effect of Interleukin-1 Receptor Antagonist (anakinra, Kineret®) on the insulin production in patients with new onset Type 1 diabetes.
- Trial name
- AIDA (NCT00711503)
- Testing
- anakinra, saline
- Where
- 17 sites in Denmark, Germany and 5 more
- Volunteers
- 69 people
- Sponsor
- Steno Diabetes Center Copenhagen
Prediabetes, Normal Plasma Glucose
The Effects of Nextida-GC and Whey Protein on Postprandial Glycemic and Insulinemic Responses When Given 30min Before, 10min Before or With a Standardized Breakfast Test-meal in Healthy Adults With and Without Prediabetes
The goals of this clinical trial are to learn if Nextida-GC (a peptide derived from collagen) will reduce postprandial glucose responses when taken 30 minutes before, 10 minutes before or with the first bite of a breakfast…
- Conditions
- Prediabetes, Normal Plasma Glucose, Normoglycemia
- Trial name
- NCT07174323
- Testing
- Peptide derived from collagen protein, Whey protein isolate
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- INQUIS Clinical Research
Diabetes Mellitus, Insulin Resistance
Effect of HIIT Vs Moderate Intensity Aerobic Exercise on Insulin Resistance in Type 2 DM
Comparing between the efficacy of high intensity interval training and moderate intensity aerobic exercises on insulin resistance in type 2 Diabetes Mellitus.
- Trial name
- NCT05902546
- Testing
- High intensity interval training, moderate intensity aerobic exercise
- Where
- 4 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Badr University
Diabetes Complications
Use of a Bearable Continuous Interstitial Glucose Monitoring Device (GuardianR) During Teaching Sessions to Functional Insulin Therapy Concept in Patients Suffering From Type 1 Diabetes: Evaluation at 6 and 12 Months
The objective of the project is to evaluate advantages from the use of a bearable continuous interstitial glucose monitoring device (GuardianR) during educative sessions of diabetic patients dedicated to functional insulin…
- Trial name
- NCT00682903
- Testing
- GuardianR
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Nitrate, Brain Insulin-sensitivity
Nitrate and Brain Insulin-Sensitivity
Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia.
- Conditions
- Nitrate, Brain Insulin-sensitivity, Vascular Function
- Trial name
- NO-BRAINS (NCT04700241)
- Testing
- Potassium nitrate
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes, Hyperglycemia
The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery
The purpose of this study was to investigate the effects of three different glycemic treatment conditions (tight, conventional, and standard) in the intraoperative period on: 1) postoperative surgical site infections, and 2)…
- Conditions
- Diabetes, Hyperglycemia, Surgical Site Infection
- Trial name
- NCT01831154
- Testing
- Tight Glycemic, Conventional Glycemic, Standard Glycemic
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Metabolic Syndrome
Amla on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
Amla has demonstrated promising effects in the treatment of obesity, dyslipidemia, hypertension, insulin secretion, among others.
- Trial name
- NCT03633630
- Testing
- Amla
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- University of Guadalajara
Type1diabetes
Alleviating Carbohydrate-Counting Burden in T1DM Using Artificial Pancreas and Empagliflozin
One of the challenges in the design of the artificial pancreas (AP) is preventing postprandial hyperglycemia. Beyond algorithmic solutions, one countermeasure to postprandial hyperglycemia that may enhance performance of the AP…
- Trial name
- CLASS15 (NCT03510000)
- Testing
- Empagliflozin 25mg, Single hormone artificial pancreas, Meal strategies
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Type 1 Diabetes Mellitus
A Trial to Investigate Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BioChaperone® Pramlintide Insulin in Patients With Type 1 Diabetes Mellitus
This is a single center, randomised, double-blind, active comparator controlled, three-period cross-over, single dose trial in subjects with type 1 diabetes mellitus.
- Trial name
- NCT03512236
- Testing
- BC Pram Ins, Symlin® and Humulin®, Humalog®
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Adocia
Diabetes
Evaluation of the DIABEO System in Poorly Controlled DM1 or DM2 Patients Treated With a Basal-bolus Insulin Regimen
The aim of the TELESAGE study is to demonstrate 1. the superiority of follow up with the DIABEO system (software alone) versus usual follow up in terms of improvement in HbA1c after 1 year in DM1 or DM2 patients treated with a…
- Trial name
- TELESAGE (NCT02287532)
- Testing
- DIABEO software
- Where
- 108 sites in France
- Volunteers
- 667 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Overweight and Obesity
High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity
This human intervention study will test if 12 weeks of supervised HIIT-based intervention improves skeletal muscle NOGD capacity in obese subjects.
- Trial name
- NCT03405545
- Testing
- High-intenstiy interval training
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Depression, Type 1 Diabetes
Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
This study is a pilot behavioral intervention trial, designed to initially examine cognitive behavioral therapy for medical adherence and depression (CBT-AD) in patients with depression and poorly controlled type 1 diabetes.
- Trial name
- NCT01527981
- Testing
- Cognitive behavioral therapy for adherence and depression
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetes, Diabetes Mellitus, Type 2
Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes Mellitus
This trial is conducted in the United States of America (USA). The aim of this trial is to compare the efficacy and safety of two different formulations of insulin degludec (IDeg) in subjects with type 2 diabetes.
- Trial name
- BEGIN™ (NCT01364428)
- Testing
- insulin degludec
- Where
- 45 sites in United States
- Volunteers
- 373 people
- Sponsor
- Novo Nordisk A/S
Kidney Transplant; Complications
Effects of Empagliflozin in Reducing Oxidative Stress After Kidney Transplantation
The purpose of this study is to investigate the effect of empagliflozin on oxidative stress in patients with type 2 diabetes after kidney transplantation.
- Trial name
- NCT04918407
- Testing
- Empagliflozin 25 MG, Insulin
- Where
- 2 sites in Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Type 1 Diabetes Mellitus
Islet Transplantation in Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00434811
- Testing
- Allogeneic Pancreatic Islet Cells, Antithymocyte Globulin, Sirolimus
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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