Clinical trials: Insulin, completed
Diabetes, Diabetes Mellitus, Type 2
Safety and Efficacy of Insulin NPH Compared to a New Insulin Formulation in Subjects With Type 2 Diabetes
This trial is conducted in South America. This trial aims for a comparison of the safety and efficacy of insulin NPH and a new insulin formulation on blood glucose control.
- Trial name
- NCT00660374
- Testing
- insulin NPH, EX1000
- Where
- Brazil
- Volunteers
- 402 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, Insulin Resistance
Study of Improving Insulin Sensitivity by Electroacupuncture Therapy
The aim of this study is to find out whether the hypoglycemic and improving insulin resistance effect will appear or not, when EA applying on specific acupoints of NIDDM patients.
- Trial name
- NCT00379379
- Testing
- electroacupuncture
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- China Medical University Hospital
Diabetes
A Study of Insulin Degludec/Insulin Aspart Biosimilar (22011) Compared With Insulin Degludec/Insulin Aspart(Ryzodeg) in Participants With Type 2 Diabetes in China
The purpose of this study is to see if Insulin Degludec/Insulin Aspart (22011) compared to Insulin Degludec/Insulin Aspart (Ryzodeg) is similar in safety and effect in participants with type 2 diabetes (T2D).
- Trial name
- NCT05802862
- Testing
- Insulin Degludec and Insulin Aspart
- Where
- China
- Volunteers
- 414 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Prediabetic State, Impaired Glucose Tolerance
Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine
The goal of this protocol is to evaluate the effect of addhing linagliptin to patients with prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin alone.
- Conditions
- Prediabetic State, Impaired Glucose Tolerance, Insulin Resistance
- Trial name
- RESCATHEME (NCT04088461)
- Testing
- Linagliptin / Metformin Oral Tablet, Metformin
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Universidad de Guanajuato
Healthy People, Diabetes Mellitus, Type 2
The Effects of Mixed Grain on Blood Glucose and Insulin in Healthy Male
This study was an open, 4-treatment, 5-sequence, 5-day cross-over randomized design clinical trial to evaluate the efficacy of mixed grain on blood glucose, insulin and Glycemic index(GI) in healthy males.
- Trial name
- NCT01840982
- Testing
- Mixed grain 1, Mixed grain 2, White rice
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format,
In previous studies, the investigators tested the feasibility of a bi-hormonal reactive closed loop system without mealtime announcement.
- Trial name
- APPEL5 (NCT03858062)
- Testing
- Insulin pump therapy (with or without glucose sensor), Artificial pancreas (Inreda Diabetic)
- Where
- 2 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- J.H. DeVries
Type 1 Diabetes Mellitus
Managing Insulin Pumps for Exercise - Study 1
People with Type 1 Diabetes Mellitus (T1DM) like to take part in sport and exercise, but problems with metabolism and blood glucose control can make this difficult.
- Trial name
- NCT01401127
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Type 2 Diabetes Mellitus, Hypertension
Vitamin D and Omega-3 Inhibit Metabolic Syndrome
The study will test the hypothesis that supplementing the diet of subjects with Metabolic Syndrome with 2000 IU vitamin D and 1.8 g omega-3 fatty acids (EPA + DHA) per day, will facilitate weight loss, improve body composition…
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, Obesity
- Trial name
- NCT01326442
- Testing
- low glycemic diet, vitamin D omega-3
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Guelph
Type 1 Diabetes Mellitus, Type 1 Diabetes
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to establish the safety and efficacy of multiple administrations of PROCHYMAL® in participants recently diagnosed with type 1 diabetes mellitus.
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Insulin-Dependent, Juvenile Diabetes
- Trial name
- NCT00690066
- Testing
- PROCHYMAL®
- Where
- 20 sites in United States
- Volunteers
- 63 people
- Sponsor
- Mesoblast, Inc.
Diabetes Mellitus, Type 2
A Research Study, Looking at How Ryzodeg® (Insulin Degludec/Insulin Aspart) Works in People With Type 2 Diabetes in Local Clinical Practice
The purpose of the study is to collect information on how Ryzodeg® works in real world patients and to see if Ryzodeg® can lower blood sugar levels. Participants will get Ryzodeg® as prescribed to them by their doctor.
- Trial name
- ARISE (NCT04042441)
- Testing
- Insulin Degludec/Insulin Aspart
- Where
- 64 sites in Australia, India and 4 more
- Volunteers
- 1,122 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Biphasic Insulin Aspart 30 FlexPen® in Insulin Naive Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the efficacy of biphasic insulin aspart 30 on blood glucose control in insulin naive type 2 diabetes failing on secondary oral hypoglycaemic agent (OHA).
- Trial name
- NCT00600366
- Testing
- biphasic insulin aspart
- Where
- 4 sites in Serbia and Montenegro
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Hypertension, Obesity
Microvascular Dilatation After Endogenous Induced Hyperinsulinemia
In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test).
- Trial name
- NCT00742456
- Testing
- Glucose solution
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Diabetes
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
- Conditions
- Obesity, Diabetes, Insulin Resistance, Fatty Liver
- Trial name
- HEPFAT (NCT01038102)
- Testing
- PUFA Diet, SFA diet
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Type 1 Diabetes Mellitus
FIasp® vs. Novolog® in Type 1 Diabetics Using 670G Medtronic Pump
This is an exploratory, single-center, randomized, open label, active-controlled, complete cross-over trial comparing safety and efficacy of Fiasp® versus NovoLog® when used in the Medtronic MiniMed 670G system in subjects with…
- Trial name
- NCT03977727
- Testing
- Fiasp®, Novolog®, 670G hybrid closed loop continuous subcutaneous insulin infusion system
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Diabetes & Endocrinology, P.A.
Addison's Disease
Glucocorticoid Treatment in Addison's Disease
Addison's disease is a rare condition which in most cases is caused by autoimmune destruction of the adrenals, leading to deficiency of cortisol, aldosterone and adrenal androgens.
- Trial name
- NCT01063569
- Testing
- Solu-Cortef (hydrocortisone), Cortef (hydrocortisone)
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 33 people
- Sponsor
- Haukeland University Hospital
Type 1 Diabetes, Dawn Phenomenon
Comparison of Lantus and Neutral Protamine Hagedorn (NPH) Insulin in the Dawn Phenomenon
1. To investigate the effect of insulin glargine (Lantus™) vs NPH insulin regarding glycemic control during the early AM (dawn phenomenon) in individuals with type 1 diabetes. 2.
- Trial name
- DAWN (NCT00694122)
- Testing
- Lantus (glargine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Healthy
Effect of Extruded Cereals Enriched With β-glucan on Postprandial Plasma Glucose and Serum Insulin Responses
β-glucan (BG) is a viscous dietary fiber present in barley and oats that, when added to carbohydrate containing foods, reduces the postprandial glycemic response (PPGR), which is considered to be beneficial to health.
- Trial name
- NCT05556837
- Testing
- Control Cereal, OBG Cereal, BBG Cereal
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Mellitus, Type 1, Insulin Hypoglycemia
Effects of Frequency and Duration of Exercise in People With Type 1 Diabetes A Randomized Crossover Study
According to the Standards of Medical Care in Diabetes by the American Diabetes Association, people with diabetes should aim for 30 minutes of moderate-to-vigorous intensity aerobic exercise at least 5 days a week or a total of…
- Trial name
- NCT04089462
- Testing
- "Five sessions per period" - "Two sessions per period", "Two sessions per period" - "Five sessions per period"
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes Mellitus
Assessment Study of Three Different Fasting Plasma Glucose Targets in Chinese Patients With Type 2 Diabetes Mellitus (BEYOND III/FPG GOAL)
Primary Objective: To identify a best fasting plasma glucose (FPG) target for Chinese type 2 diabetes patients using insulin glargine which can provide the highest control rate of glycated hemoglobin (HbA1c) < 7%.
- Trial name
- NCT02545842
- Testing
- INSULIN GLARGINE
- Where
- 44 sites in China
- Volunteers
- 947 people
- Sponsor
- Sanofi
Treatment Resistant Essential Hypertension, Insulin Resistance
The Effects of Renal Denervation on Insulin Sensitivity
Renal sympathetic nerves contribute to development of hypertension. Sympathetic overactivity also induces insulin resistance and it could therefore be assumed that a renal denervation might improve insulin sensitivity.
- Trial name
- NCT01631370
- Testing
- Renal denervation
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
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