Clinical trials: Insulin, completed
Type 2 Diabetes Mellitus
Metabolic Activation With Almased for Type 2 Diabetes Patients
Overweight patients with type 2 diabetes are often being treated with an intensified insulin therapy. However, in many cases, even a high insulin dosage (> 100 U per day) does not achieve satisfying metabolic control.
- Trial name
- Almased100 (NCT01680926)
- Testing
- Almased
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- West German Center of Diabetes and Health
Insulin Resistance, Diabetes Mellitus
A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
The goal of this study is to aggressively treat insulin resistance and its clinical manifestations when they first appear in childhood, and to prevent the subsequent progression towards impaired glucose tolerance and type-2…
- Trial name
- NCT00015626
- Testing
- Metformin, skin biopsy, diet and exercise
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Center for Research Resources (NCRR)
Secondary Pancreatic Diabetes
Closed-loop Insulin Delivery Systems in Pancreatic Diabetes
The purpose of this study is to evaluate the metabolic and the safety outcomes in people living with pancreatic diabetes (pancreatitis or pancreatectomy-induced diabetes) and using a closed-loop insulin delivery systems…
- Trial name
- IADIASP (NCT06227650)
- Testing
- hybrid closed loop insulin delivery system
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Sud Francilien
Lactate, Healthy
Lactate in the Gut
Lactate is formed naturally in the body in example during physical activity. However, lactate is also formed during food fermentation where certain bacterial strains form lactate. Lactate can also be produced chemically.
- Conditions
- Lactate, Healthy, Hyperlactatemia
- Trial name
- NCT04299815
- Testing
- Oral Sodium Lactate, Intravenous sodium lactate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Normal Non-fluency
Effect of Short Term Atypical Antipsychotic Administration Compared to Placebo on Hepatic Insulin Extraction
Within the past 20 years, there has been a striking increase in the incidence of obesity 1;2, type 2 diabetes mellitus (T2DM) 3-5, and cardiovascular diseases (CVD) in the schizophrenic population 6-8 .
- Trial name
- NCT02447835
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michael Rickels
Type 1 Diabetes, Type 2 Diabetes
User Evaluation of the MiniMed 640G Insulin Pump
This four center international study will include two United Kingdom National Health Service centers, and two centers in Melbourne, Australia.
- Trial name
- NCT01991548
- Testing
- MiniMed® 640G Insulin Pump and Guardian® Link Transmitter
- Where
- 4 sites in Australia, United Kingdom
- Volunteers
- 52 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type 2
MSC and MC in Type 2 Diabetes Mellitus
Cell injury in human islets induced by non-immune mediated inflammation occur in vitro upon hyperglycemia in type 2 diabetes mellitus.
- Trial name
- NCT01719640
- Testing
- infusion of MSCs, infusion MCs, insulin
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Fuzhou General Hospital
Diabetes, Diabetes Mellitus
Validation of an App in the Elderly Population With Diabetes Mellitus.
A randomized clinical trial comparing the intervention group, which will use a mobile app, with the control group (without a mobile app).
- Conditions
- Diabetes, Diabetes Mellitus, Elderly, ELDERLY PEOPLE
- Trial name
- SMARTDIABETES (NCT07591415)
- Testing
- Smartdiabetes
- Where
- 3 sites in Spain, Sweden
- Volunteers
- 60 people
- Sponsor
- Leocadio Rodriguez Mañas
Insulin Secretion
Glucagon Regulation of Glucose Metabolism
Glucagon is a 30 amino acid peptide hormone that is produced exclusively in alpha-cells of the pancreatic islets. Glucagon binds to a G-protein coupled receptor and activates intracellular signaling by increasing the synthesis of…
- Trial name
- NCT04347252
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- David D'Alessio, M.D.
Type 2 Diabetes, Vitamin D Insufficiency
Metabolic Effects of Vitamin D in Patients With Type 2 Diabetes
The purpose of the study is to examine the effect on metabolic parameters after 12 weeks of treatment with high dose vitamin D in patients with type 2 diabetes and vitamin D insufficiency.
- Trial name
- ProjectD (NCT00812578)
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus
Clomiphene Citrate Resistant Polycystic Ovary Syndrome
Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate
This study evaluate the addition of Vit E to clomiphene citrate in the treatment of poly cystic ovary.Half the patients will receive both Vit E and clomiphene citrate the other half will receive clomiphene citrate only.
- Trial name
- NCT03674385
- Testing
- vitamin E, Metformin, Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase
The purpose of this study is to evaluate consistency of accelerated insulin absorption and onset-of-action and shortened duration of action for bolus insulin infusions after pretreatment with 150 units (U) of Hylenex®…
- Trial name
- NCT01526733
- Testing
- Recombinant human hyaluronidase PH20, Insulin aspart, Insulin lispro
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Halozyme Therapeutics
Hyperglycaemia During Perioperative Period, Heart Valve Diseases
Glucose Control in Open Heart Surgery
The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery
- Conditions
- Hyperglycaemia During Perioperative Period, Heart Valve Diseases, Ventricular Dysfunction
- Trial name
- NCT00370643
- Testing
- human regular insulin
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo
Type 1 Diabetes
Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Insulin Clamp Ancillary study for Assessment of Insulin Resistance will be conducted as a sub-study to the main protocol, Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (NCT01881828).
- Trial name
- NCT02045290
- Testing
- Metformin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Jaeb Center for Health Research
Diabetes, Diabetes Mellitus, Type 2
Observational Study of Safety and Effectiveness of NovoMix® 30 for the Treatment of Diabetes
This study is conducted in Asia, Europe, Japan and North America. The aim of this observational study is to evaluate the safety and effectiveness while using NovoMix® 30 during 26 weeks under normal clinical practice, in the…
- Trial name
- IMPROVE™ (NCT00659282)
- Testing
- biphasic insulin aspart
- Where
- 11 sites in Canada, China and 9 more
- Volunteers
- 57,610 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Dexcom Hybrid Closed Loop Insulin Pump Study in Type 1 Diabetes
Treatment of Type 1 diabetes requires daily insulin therapy given by either multiple daily injections or by continuous infusion via a pump.
- Trial name
- NCT05059860
- Testing
- Tandem Control IQ Hybrid Closed Loop Insulin Delivery System
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Lothian
Insulin Resistance
The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans
In this research study, investigators will test the effects of an approved medication for diabetes,Liraglutide, to reduce insulin resistance that develops from eating a diet high in saturated fats.
- Trial name
- NCT02403284
- Testing
- Liraglutide, Sugar Pill
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Phoenix VA Health Care System
Lipodystrophy, Dunnigan Syndrome
Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy
The objective of this work is to identify biomarkers of interest in patients with insulin resistance leading to early disorders of glycemic regulation.
- Trial name
- IRAP-DUN 2 (NCT05424913)
- Testing
- research-specific blood sample
- Where
- Reunion
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
ST-Elevation Myocardial Infarction
PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus
Dual antiplatelet therapy is essential in patients following ST-Elevation myocardial infarction (STEMI) with percutaneous coronary intervention (PCI) and drug eluting stent implantation.
- Trial name
- RESET 2D (NCT01531114)
- Testing
- ticagrelor, prasugrel
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Gennaro Sardella
Type 1 Diabetes
52 Week Trial of Liraglutide in Type 1 Diabetes
To our knowledge, no trial has specifically studied the effect of liraglutide combined with a basal/bolus insulin regimen in type 1 diabetes in a cross-over, double-blind, unicentric model.
- Trial name
- LIDO (NCT01787916)
- Testing
- Liraglutide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- CHU de Quebec-Universite Laval
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