Clinical trials: Insulin, completed
Diabetes Mellitus Type 2
Near Normalisation of BG Improves the Potentiating Effect of GLP-1
The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals.
- Trial name
- NCT00612625
- Testing
- glucagon-like peptide-1, Saline
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type 2
Effects on Insulin Resistance With Tadalafil in Type 2 Diabetes - a Double-blind, Placebo-controlled Crossover Study
The aim is to continue our program on PDE5 inhibition by evaluating effects on insulin resistance, including glucose metabolism and subclinical inflammation, after a 6-week administration of tadalafil in T2D patients.
- Trial name
- MAKROTAD (NCT02601989)
- Testing
- Tadalafil
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- Göteborg University
Type 2 Diabetes Mellitus
Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes
This is a multi-centre, open-label, randomized, parallel trial to compare the effect of Exenatide versus Biphasic insulin Aspart 30 on glucose variability and inflammatory markers in type 2 diabetes mellitus (T2DM) patients…
- Trial name
- NCT02449603
- Testing
- Exenatide, Biphasic insulin Aspart 30
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital
Cardiovascular Diseases, Atherosclerosis
Insulin Resistance Atherosclerosis Study (IRAS)
To conduct a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-Hispanic white) population aged 40 to 69…
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Diabetes Mellitus, Heart Diseases
- Trial name
- NCT00005135
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes Under Free Living Conditions (AP@Home04_Phase 4)
The main objective of this study is to determine whether home use of day and night closed loop insulin delivery under free living conditions applying ultra-rapid insulin lispro (Lyumjev) is superior to home use of closed-loop…
- Trial name
- NCT05257460
- Testing
- Hybrid closed-loop using ultra-rapid insulin lispro, Hybrid closed-loop using standard insulin lispro
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Cambridge
Type 2 Diabetes
Combination of Sulfonylureas and Insulin Glargine Outpatient Therapy for Unstable Diabetes and Impending DKA
The purpose of this study is to compare two simple and safe emergency department discharge therapy for Type 2 Diabetes patients with severe hyperglycemia and with no indications for inpatient admission.
- Trial name
- NCT00732524
- Testing
- Glipizide, Glipizide and Glargine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cook County Health
Obesity
Circulating IL-6, Clusterin and Irisin in Obese Subjects
evaluate the circulating levels of IL-6, clusterin and irisin in obese subjects of both sexes who had different classes of obesity and their sexual dimorphism also identify the association of IL-6, clusterin and irisin with…
- Trial name
- NCT04133896
- Testing
- IL-6, Clusterin, Irisin Level
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Rehab Werida
Diabetes Mellitus
Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas
The investigators hypothesize that our closed-loop glucose-control system can provide BG control in subjects with type 1 diabetes using the estimated BG signal from a CGM as the input signal to the controller.
- Trial name
- CL2 (NCT01161862)
- Testing
- Bi-hormonal (insulin and glucagon) artificial pancreas
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston University Charles River Campus
Sleep Restriction, Impaired Glucose Metabolism
The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction
The purpose of the study is to examine the effects of sleep and modafinil on how the body processes glucose.
- Trial name
- NCT00895570
- Testing
- modafinil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes Mellitus
Reinforcement of the Impact of a Functional Insulin Therapy Training Course by Telemonotoring With a PDA-phone in Type 1 Diabetic Patients. The TELFIT Study Patients
TELFIT is a monocenter, controlled, randomised trial. It focuses on type 1 diabetes patients that have attended a functional insulin therapy training course.
- Trial name
- TELFIT (NCT00758082)
- Testing
- paper support, PDA-phone + telemonitoring
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Validation of Sleep Healthcare System
The present project aims to that examine the interplay between sleep duration circadian phase, and metabolic regulation. The impact of CPAP therapy on metabolic regulation is assessed with a RCT.
- Trial name
- NCT04252482
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Insulin Sensitivity, Obesity
Exercise and Insulin Signaling in Human Skeletal Muscle
Obesity is associated with a decrease in skeletal muscle insulin sensitivity. Aerobic exercise can increase insulin sensitivity in the few hours following exercise, however the cellular mechanisms are not completely understood.
- Conditions
- Insulin Sensitivity, Obesity, Sedentary Lifestyle
- Trial name
- NCT02987491
- Testing
- Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Type 1 Diabetes Mellitus
A Trial to Assess the Efficacy and Safety of M1 Pram P037 Prandial Insulin in Subjects With Type 1 Diabetes (T1DM)
In this trial, the treatment of subjects with type 1 diabetes with M1 Pram P037 as co-formulation of pramlintide and A21G human insulin analogue product will be compared with a current standard treatment, insulin lispro.
- Trial name
- NCT04816890
- Testing
- M1 Pram P037, Insulin lispro
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Adocia
Hepatic Steatosis, Bariatric Surgery Candidate
Hepatic Mitochondrial Function in Youth
Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth
- Conditions
- Hepatic Steatosis, Bariatric Surgery Candidate, Adolescent Obesity, Obesity
- Trial name
- MANGO (NCT03587727)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
BD FlowSmart™ Subcutaneous Insulin Infusion Set User Preference and Claims Study
Continuous Subcutaneous Insulin Infusion (CSII) via insulin pump therapy has been shown to improve quality of life and glucose control in many patients with diabetes opting for this treatment modality.
- Trial name
- NCT02662842
- Testing
- FlowSmart Infusion Set, Current Infusion Set
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Becton, Dickinson and Company
Diabetes Mellitus
Diabetes and Travel: Evaluation of a Diabetes Education Module - a Randomized Controlled Trial (PRIMO_Travel)
This study is a multi-center, randomized prospective trial with a 6-month follow up. A newly developed treatment and education module will be tested compared to a waiting-list control group.
- Trial name
- PRIMO_Travel (NCT02077686)
- Testing
- Education - Diabetes and Travel
- Where
- 4 sites in Germany
- Volunteers
- 262 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Diabetes Type 1
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
Arterial vascular disease is the major cause of morbidity and mortality for Type 1 diabetic patients (DM1). Metabolic insulin resistance (metIR), even in the absence of hyperglycemia, conveys a 1.5 to 3-fold increased CVD risk in…
- Trial name
- EJB046 (NCT02490124)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes
Evaluation of Glycemic Control in Adults With Type 1 Diabetes When Switching to Insulin Degludec
Retrospective multicenter study analyzing data gathered from medical records and diabetes management platforms to assess the effect of using Insulin Degludec (Tresiba®) on measures of diabetes control.
- Trial name
- GLADE (NCT05434559)
- Testing
- Insulin Degludec
- Where
- 2 sites in Belgium
- Volunteers
- 475 people
- Sponsor
- prof dr Pieter Gillard
Diabetes, Healthy
Safety and Tolerability of Insulin Degludec/Liraglutide (A3) in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to compare the bioavailability of insulin degludec and liraglutide, when administered either combined or as separate administrations.
- Trial name
- NCT01319240
- Testing
- insulin degludec, insulin degludec/liraglutide, liraglutide
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Novo Nordisk A/S
Major Depressive Disorder
Effect of Intranasal Insulin on Depressive Symptoms in Major Depressive Disorder
The primary aim of the study is to determine whether adjunctive intranasal insulin will exert an antidepressant effect when compared to placebo in adults with major depressive disorder (MDD), insufficiently responsive…
- Trial name
- NCT00570050
- Testing
- Diluent / Insulin, Insulin / Diluent
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University Health Network, Toronto
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