Clinical trials: Insulin, completed
Diabetes, Diabetes Mellitus, Type 2
A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type 2 Diabetes Treated With Basal Insulin With or Without Oral Antidiabetic Treatment in Need of Treatment Intensification
Trial comparing effect and safety of insulin degludec/insulin aspart vs. insulin glargine plus insulin aspart in subjects with type 2 diabetes treated with basal insulin with or without oral antidiabetic treatment in need of…
- Trial name
- NCT02906917
- Testing
- Insulin degludec/insulin aspart, Insulin glargine, Insulin aspart
- Where
- 71 sites in United States, Algeria and 5 more
- Volunteers
- 532 people
- Sponsor
- Novo Nordisk A/S
Bariatric Surgery, Type 1 Diabetes
Hybrid Closed Loop Insulin Pump and Bariatric Surgery in Patients With Type 1 Diabetes
Bariatric surgery is increasingly performed on patients with type 1 diabetes. It exposes these patients to an increased risk of hypoglycemia, including severe hypoglycemia, and of severe episodes of hyperglycemia, beyond the…
- Trial name
- PompBariatDT1 (NCT06294704)
- Testing
- bariatric surgery
- Where
- 3 sites in France
- Volunteers
- 17 people
- Sponsor
- Centre Hospitalier Sud Francilien
Vitamin D Receptor Defect
Endometrial Vitamin D Receptor in PCOS
Vitamin D receptor (VDR) is widely expressed not only in tissues responsible for calcium hemostasis, but also in reproductive organs, including the endometrium.
- Trial name
- NCT05885633
- Testing
- endometrial sampling with pipelle
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Uşak University
Type 2-diabetes
Acute Hyperbaric Oxygen Treatment Increases Hepatic Insulin Sensitivity and Muscle Reactive Oxygen Species in T2D
Diabetes mellitus type 2 (T2D) is characterized by insulin resistance of liver and skeletal muscle, which is at least partly due to impaired muscle mitochondrial function.
- Trial name
- NCT04219215
- Testing
- 100% O2 in oxygen chamber, 21% O2 in oxygen chamber
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- German Diabetes Center
Insulin Sensitivity, Apathy
Lifestyle Intervention for Improving Insulin Resistance and Concern for Health
The primary objective of this study is to test the effect of a diet and exercise program in older adults with insulin resistance and a motivation disorder known as apathy. The main questions the study aims to answer are: 1.
- Trial name
- NCT05649176
- Testing
- Diet without soy, Diet with soy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes Mellitus
Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes
The purpose of this study is to determine in type 2 diabetic patients in secondary failure to combined oral therapy whether, besides improvement in glycemic control, addition of exenatide, a new drug introduced to treat diabetes…
- Trial name
- NCT00948168
- Testing
- exenatide (Byetta)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Polycystic Ovary Syndrome
A Reduced Carbohydrate Diet Intervention for Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age, and is associated with infertility, risk for obesity and type 2 diabetes, and impaired quality of life.
- Trial name
- NCT01028989
- Testing
- Reduced Glycemic Load Diet, Standard Diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Type 1 Diabetes Mellitus
A Study of t:Slim X2 With Control-IQ Technology
The purpose of this study is to learn whether an investigational automated insulin delivery system ("study system") for children with type 1 diabetes can safely improve blood glucose (sometimes called blood sugar) control.
- Trial name
- DCLP5 (NCT03844789)
- Testing
- t:slim X2 with Control-IQ Technology & Dexcom G6 CGM, Control Group
- Where
- 4 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Virginia
Type 2 Diabetes Mellitus
Study of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents
This study will look at the safety of substituting exenatide for insulin in patients with type 2 diabetes who are currently taking insulin and oral antidiabetic agent(s).
- Trial name
- NCT00099333
- Testing
- exenatide, Insulin
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- AstraZeneca
Nonalcoholic Fatty Liver Disease
Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH)
The primary objective is to test the hypothesis that 24 weeks of treatment with exenatide will improve the histological acitvity of NASH (steatosis,necroinflammation, ballooning), summarized in the recently introduced NASH-score…
- Trial name
- NCT01208649
- Testing
- Exenatide
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Diabetes, Diabetes Mellitus, Type 2
Observational Study to Assess the Quality of Life and Clinical Outcomes in Subjects Using NovoMix® 30 for the Treatment of Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate the quality of life and clinical outcomes in subjects using NovoMix® 30 (biphasic insulin aspart 30) for the treatment of diabetes mellitus under…
- Trial name
- IMPROVE Life (NCT00696163)
- Testing
- biphasic insulin aspart 30
- Where
- India
- Volunteers
- 24,975 people
- Sponsor
- Novo Nordisk A/S
Hyper-LDL-cholesterolemia, Metabolic Syndrome
The Effects of Strawberries on Blood Cholesterol.
In this study, we propose to investigate the effects of dietary achievable doses of strawberries on serum LDL-cholesterol (LDL-C) and related lipid profiles, measures of glycemia and insulin resistance, and biomarkers of…
- Trial name
- NCT03441620
- Testing
- strawberries, Control powder
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Nevada, Las Vegas
Type 1 Diabetes Mellitus
Concurrent Use of Two Continuous Glucose Monitoring Systems in Adults With Type 1 Diabetes Mellitus (T1DM)
The purpose of this pilot study is to evaluate performance of the SEVEN System and the Navigator System when both devices are worn concurrently by subjects with type 1 diabetes mellitus.
- Trial name
- NCT00939289
- Testing
- Continuous Glucose Monitoring
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- DexCom, Inc.
Metabolic Syndrome
Effect of Fasting With Two Meals on Insulin Resistance Indices of Metabolic Syndrome
this study was conducted to assess the insulin resistance indices in the subjects undergoing Ramadan fasting (diet which consisted of two meals at 12 hours intervals)for a thirty days period.
- Trial name
- NCT00429390
- Testing
- Ramadan Fasting
- Volunteers
- 55 people
- Sponsor
- Free Islamic University of Medical Sciences
Insulin Resistance, Oligospermia
Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Conditions
- Insulin Resistance, Oligospermia, Azoospermia
- Trial name
- NCT01509482
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Egyptian IVF-ET Center
Insulin Resistance
Free Fatty Acid Induced Insulin Resistance
This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
- Trial name
- FFAIR (NCT01229059)
- Testing
- Lipovenös lipid infusion
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Obesity, Insulin Resistance
Mineralocorticoid Receptor and Obesity Induced Cardiovascular Complications
The purpose of this study is to find out if spironolactone, a drug that blocks the action of aldosterone, can make the blood vessels work better in people with obesity.
- Trial name
- NCT01406015
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Overweight
Whey Protein Intake With and Without Exercise on Visceral Fat: The P+RISE Study
Dietary manipulation is proving to be an effective lifestyle strategy to combat the obesity epidemic. Increased dietary protein is one effective strategy.
- Trial name
- P+RISE (NCT01960335)
- Testing
- Whey Protein, Whey Protein and Resistance Exericse, Whey Protein and RISE exercise routine
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Cardiovascular Diseases, Heart Diseases
Epidemiology of Insulin and Dehydroepiandrosterone Sulfate and Coronary Heart Disease Mortality
To determine whether serum insulin is a risk factor for coronary heart disease morbidity and mortality and whether dehydroepiandrosterone sulfate (DHEAS) is a risk factor for coronary heart disease mortality.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005246
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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