Clinical trials: Insulin, completed
Type 2 Diabetes
Phenotype Evaluation in Insulin Naive Patients Using Lantus (Insulin Glargine)
Primary objective: Efficacy assessment of the percentage of positive responders patients receiving Lantus plus glucophage association.
- Trial name
- GALATEE (NCT00653302)
- Testing
- Lantus (insulin glargine) + Glucophage (Metformin)
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Sanofi
Overweight, Obesity
Protein, Fiber, and Metabolic Syndrome - The PROFIMET Study
Randomized controlled single-blinded intervention study in 111 overweight and obese subjects with risk factors of developing type 2 diabetes, with the aim to investigate effects of isoenergetic high cereal fiber as compared with…
- Conditions
- Overweight, Obesity, Metabolic Syndrome
- Trial name
- PROFIMET (NCT00579657)
- Testing
- control diet, supported by dietary supplement twice daily, high cereal fiber diet, supported by dietary supplement twice daily, high protein diet, supported by dietary supplement twice daily
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Type 1 Diabetes
Validation of the Artificial Pancreas Diabeloop Algorithm in the Hospital
To assess whether the DIABELOOP algorithm provides better glycemic control than the usual algorithm of T1D patients on pump therapy: at meals, with CHO roughly assessed by the patient.
- Trial name
- WP6-1 (NCT02101229)
- Testing
- Insulin, Asp(B28)-
- Where
- 3 sites in France
- Volunteers
- 17 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes Mellitus, Type 1
Optimizing Metabolic Control in Type 1 Diabetes - The Automatic Bolus Calculator Flash Study
This study aims to compare the effect of flash glucose monitoring (FGM) with traditional self-monitoring of blood glucose (SMBG) with or without carbohydrate counting and automated bolus calculation, in patients with type 1…
- Trial name
- NCT03682237
- Testing
- Carbohydrate counting, automated bolus calculation, Flash glucose monitoring (FGM)
- Where
- Denmark
- Volunteers
- 184 people
- Sponsor
- Steno Diabetes Center Copenhagen
Obesity, Severe Obesity
Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service
Whether greater weight loss is as a result of a smaller reduction in energy expenditure with caloric restriction is not known. Resting energy expenditure and 24-hour energy expenditure vary substantially between individuals.
- Conditions
- Obesity, Severe Obesity, Sleep Apnoea
- Trial name
- ECAL (NCT03638895)
- Testing
- ECAL Indirect Calorimeter, Diet, exercise & behaviour modification therapy
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Type 1 Diabetes Mellitus
Real-world Effectiveness and Safety of Omnipod 5 in Adults With Type 1 Diabetes: a 12-month Observational Study.
This retrospective observational cohort study aims to evaluate the real-world effectiveness and safety of the Omnipod® 5 Automated Insulin Delivery System in adults with type 1 diabetes receiving routine clinical care at a…
- Trial name
- NCT07696039
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Papa Giovanni XXIII Hospital
Inflammatory Bowel Diseases
The Role of Peripheral and Tissue Chitinase 3-like 1 Protein Levels as a Bio-marker in IBD
The digestive system may be involved in various pathologic conditions, with different inflammatory, metaplastic and neoplastic aspects.
- Trial name
- NCT03154905
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Obesity, Glucose Intolerance
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance…
- Conditions
- Obesity, Glucose Intolerance, Exercise Capacity
- Trial name
- NCT00971594
- Testing
- Dietary counseling, AEX
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Insulin Resistance
Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- NI EGP highBMI (NCT03383822)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 1
PK/PD Biosimilarity Study of Gan & Lee Insulin Glargine Injection vs.US & EU Lantus® in Type 1 Diabetes Mellitus Patients
Primary objectives: To demonstrate biosimilarity with regard to the total and maximum pharmacokinetic exposure during one dosing interval (AUC ins. 0-24h, Cins.
- Trial name
- NCT04236895
- Testing
- Gan & Lee Insulin Glargine Injection
- Where
- 2 sites in Germany
- Volunteers
- 114 people
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Diabetes
Experimental Study to Validate the Modified Glucose Disposal Test
Evaluate the modified GDT as a measure of key metabolic characteristics in healthy subjects and those with type 2 diabetes mellitus
- Trial name
- NCT01152372
- Testing
- Insulin, glucose and staple isotopes
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Bristol-Myers Squibb
Type 1 Diabetes
Continuous Glucose Sensing at the Site of Subcutaneous Insulin Administration
The study seeks to evaluate a novel treatment approach for performing continuous real-time glucose sensing and insulin delivery at the same subcutaneous tissue site.
- Trial name
- NCT02359617
- Testing
- insulin delivery, glucose sensing
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Critical Illness, Hyperglycemia
Comparing Two Ways of Controlling Blood Sugar With Insulin in Patients Admitted to the Intensive Care Unit
The purpose of this study is to determine if there is any difference between two ways of controlling blood sugar with insulin. In patients admitted to the intensive care unit, blood sugar levels often rise due to the stress of…
- Trial name
- NCT00166491
- Testing
- Insulin
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Effects of Pre-Exercise Basal Insulin Manipulation on Glucose Dynamics in Females vs. Males With Type 1 Diabetes
The Purpose of the Study The purpose of this study is to compare how blood sugar levels change during exercise in men and women with type 1 diabetes (T1D).
- Trial name
- NCT07550608
- Testing
- 50% Pre-Exercise Basal Insulin Rate Reduction (BIRR), Habitual Basal Insulin Rate Maintenance
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Naama Constantini
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies
This was a 10-week, placebo-controlled, randomized study to investigate the effect of injectable IL-1B antagonist, Canakinumab , in participants with impaired glucose tolerance or Type 2 Diabetes Mellitus (T2DM) already treated…
- Trial name
- NCT01068860
- Testing
- Canakinumab 150 mg
- Where
- 52 sites in United States, Australia and 5 more
- Volunteers
- 246 people
- Sponsor
- Novartis
Diabetes
Comparison of Premixed Insulin With Basal-plus Insulin in Type 2 Diabetes Patients
Comparison of efficacy and safety of different insulin regimens between basal bolus and premixed insulin in poorly controlled type 2 diabetes
- Trial name
- COMPAR (NCT02219750)
- Testing
- switch twice-daily insulin
- Where
- Taiwan
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Diabetes, Diabetes Mellitus, Type 2
A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0148-0000-0362 in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (exposure of drug) and pharmacodynamics (effect of drug) of NNC 0148-0000-0362 as tablets in healthy…
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT01597713
- Testing
- NNC 0148-0000-0362, insulin glargine
- Where
- Germany
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity, Adolescent
Insulin Resistance, Lipid Profile, CRP, IL-18 and Carotid Intima-Media Thickness (CIMT) Diameter in Obese Adolescents
Carotid intima-media thickness (CIMT) is a marker for detecting endothelium dysfunction, and has become a non-invasive method that is very useful in detecting and evaluating subclinical atherosclerosis in obese children and…
- Trial name
- CIMT (NCT06152068)
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
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