Clinical trials: Insulin, completed
Diabetes Mellitus, Type 2
To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with diabetes when tasting sweet.
- Trial name
- NCT03680482
- Testing
- Intervention ingest a 48 mg of sucralose, Intervention ingest a 96 mg of stevia
- Volunteers
- 17 people
- Sponsor
- University of Chile
Type 1 Diabetes
Artificial Pancreas in Pediatric Patients (PEDarPAN)
The purpose of this study is to determine safety, feasibility and efficacy (with respect to sensor- augmented pump therapy) of an Artificial Pancreas (AP) prototype in day and night closed-loop control in children and adolescents…
- Trial name
- PEDarPAN (NCT02620878)
- Testing
- artificial pancreas, sensor augmented pump
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University of Padova
Mild Cognitive Impairment
Metformin in Amnestic Mild Cognitive Impairment
Hyperinsulinemia and type 2 diabetes (T2D) are important potential risk factors for cognitive decline and Alzheimer's disease (AD).
- Trial name
- MCI (NCT00620191)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Adenotonsillar Hypertrophy
Intranasal Midazolam for Preanasthetic Sedation for Preschool Children Undergoing Adenotonsillectomy.
This study aims to evaluate the effectiveness of Intranasal Midazolam as preanasthetic sedation for preschool children (2-6)y undergoing adenotonsillectomy.
- Trial name
- NCT07045597
- Testing
- intranasal normal saline for preanasthetic sedation for Adenotonsillectomy, intranasal midazolam for preanasthetic sedation for Adenotonsillectomy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Obesity
Meta-analysis of Soluble Fiber Consumption on Body Weight, Glycemia, and Insulinemia in Overweight and Obese Adults.
Dietary fiber intake is protective against overweight and obesity; however, a significant fiber gap exists between consumption and recommended intake values.
- Trial name
- NCT03003897
- Testing
- Soluble Fiber
- Where
- United States
- Volunteers
- 609 people
- Sponsor
- University of Illinois at Urbana-Champaign
Type 1 Diabetes Mellitus
Closed Loop Control in Adolescents Using Heart Rate as Exercise Indicator
The purpose of this study is to see if the Artificial Pancreas (AP) Platform can successfully control blood sugar in people with type 1 diabetes mellitus on insulin pump therapy in a hospital setting.
- Trial name
- NCT01945060
- Testing
- heart rate Control to Range System (hrCTR) using DiAs Platform, DiAs Control-to-Range System not informed for heart rate
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Marc Breton
Diabetes Mellitus, Type 1, Healthy Volunteers
A Study to Look at How Safe NNC0268-0965 is in Healthy People and People With Type 1 Diabetes
This study is investigating the safety and tolerability of the new medicine NNC0268-0965 (referred to as insulin 965), its concentrations in the blood and its effect on blood sugar for the treatment of diabetes.
- Trial name
- NCT03965013
- Testing
- NNC0268-0965, insulin glargine
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type I Diabetes
Evaluating the Impact of Introducing Basaglar, a Long-acting Analog Insulin, on Clinical and Quality of Life Outcomes in Youth with Diabetes in Bangladesh
This study aimed to determine the effect of introducing Basaglar and insulin pen injection devices on clinical and quality of life (QOL) parameters in children and young adults with type 1 diabetes in Bangladesh
- Trial name
- NCT06674135
- Testing
- biosimilar insulin glargine
- Where
- Bangladesh
- Volunteers
- 202 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Diabetes, Diabetes Mellitus, Type 2
Observational Study on Treatment Satisfaction of Levemir® Versus Protaphane® During "Real-life" Usage in Germany
This NON INTERVENTIONAL OBSERVATIONAL STUDY is conducted in Europe. The purpose of this NON INTERVENTIONAL OBSERVATIONAL STUDY is to primarily investigate treatment satisfaction when using Levemir® versus Protaphane® in…
- Trial name
- NCT00665808
- Testing
- insulin detemir, isophane human insulin
- Where
- Germany
- Volunteers
- 8,125 people
- Sponsor
- Novo Nordisk A/S
Heart Failure, Diabetes
DANHEART (H-HeFT and Met-HeFT)
The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin hydrochloride.
- Trial name
- DANHEART (NCT03514108)
- Testing
- Hydralazine Isosorbide Dinitrate, Metformin Hydrochloride
- Where
- 26 sites in Denmark
- Volunteers
- 1,100 people
- Sponsor
- Henrik Wiggers
Type 1 Diabetes
Performance Evaluation of a Non-Invasive Glucose Monitor as Compared to CGM Data Acquired by the iPro2
This study is for adults and adolescents with type 1 diabetes. The purpose of this study is to learn more about an investigational system to measure blood glucose.
- Trial name
- NCT01831752
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes Mellitus, Type 2
Six Month Clinical Trial Assessing Efficacy And Safety Of Inhaled Insulin In Type 2 Diabetes
To determine, in subjects with Type 2 Diabetes Mellitus: 1. Whether glycemic control can be achieved at least as effectively with an insulin regimen involving pre-meal EXUBERA™ (inhaled insulin) plus a single bedtime Ultralente…
- Trial name
- NCT00424411
- Testing
- Inhaled human insulin (EXUBERA™)
- Where
- 45 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Pfizer
Type2 Diabetes
Stem Cells From Human Exfoliated Teeth in Treatment of Type 2 Diabetes
To evaluate the safety and efficacy of Stem Cells From Human Exfoliated Teethtransplantation in patients with type 2 diabetes to provides scientific basis for further clinical studies to verify the safety and efficacy of type 2…
- Trial name
- NCT03658655
- Testing
- Stem Cells From Human Exfoliated Teeth
- Where
- China
- Volunteers
- 24 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
HIV I Infection, Adiposity
Assessing the Impact of INSTI to PI Switch on Insulin Sensitivity and Fat Metabolism
A substudy of TMC114FD2HTX4004 that will perform glucose tolerance testing, adipose testing and MRI scan at baseline, 12 and 24 weeks post switch of ART medications.
- Trial name
- ADIPOSITY (NCT04675255)
- Testing
- Frequently sampled glucose tolerance testing, abdominal subcutaneous adipose tissue biopsy, MRI scan to assess intrahepatic triglyceride content
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Kids
An open-label, three-center, randomized, two-session, 4 days inpatient and 6-week follow-up home study phase, crossover study comparing Diabeloop closed-loop (CL) system and sensor-augmented pump (SAP) therapy.
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Young Children (6 to 12 Years Old )
- Trial name
- DBL4K (NCT03671915)
- Testing
- Continuous Glucose Monitoring, External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France
- Volunteers
- 21 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating NN1218 in Subjects With Type 1 and Type 2 Diabetes
This trial is conducted in Europe and in the United States of America (USA). The aim of this trial is to investigate the absorption and effect in the body of NN1218 in subjects with type 1 and type 2 diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01121276
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Hypertension
Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and…
- Trial name
- NCT02665117
- Testing
- Potassium Magnesium Citrate (KMgCit), Potassium Chloride (KCl), Chlorthalidone
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Overweight and Obesity
Effect of Diet Supplementation With Amaranth Protein on Mexican Children With Overweight and Obesity
The state of San Luis Potosí comprises several municipalities with diverse environmental conditions, ranging from semi-tropical to very arid zones. Arid zones have a high rate of childhood with obesity.
- Trial name
- AmProtObes (NCT07583043)
- Testing
- AmProt (amaranth protein isolate)
- Where
- Mexico
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Instituto Potosino De Investigacion Cientifica Y Tecnologica AC
Hypoglycemia
Effect of Fasting on Insulin-induced Hypoglycemia Counterregulation in Healthy Humans
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT04392843
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Dysglycemia, Type 2 Diabetes Mellitus
Alkaline Diet for Insulin Sensitivity
The purpose of this study is to test the effect of increasing the body pH acutely with an alkaline medication (sodium bicarbonate, NaHCO3, sodibic) on glucose metabolism post meal in non diabetic subjects with normal renal…
- Trial name
- ADIS (NCT02501343)
- Testing
- Sodium Bicarbonate Oral Capsule
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
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