Clinical trials: Insulin, completed
Obesity, Metabolic Syndrome
Metabolic Impact of Fructose Restriction in Obese Children
The sugar fructose has been implicated not just as a cause of obesity, but as a cause of the metabolic diseases that go along with obesity, termed "metabolic syndrome".
- Trial name
- SUCRE (NCT01200043)
- Testing
- fructose restriction diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, San Francisco
Healthy
A Study of LY3374849 in Healthy Participants
The aim of this trial is to evaluate the safety and tolerability of the study drug known as LY3374849, when given as an injection to healthy participants.
- Trial name
- NCT03726125
- Testing
- LY3374849 - SC, Insulin Degludec - SC, LY3374849 - IV
- Where
- Singapore
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Insulin Resistance, Proteomics
Proteomics in Morbid Obesity After Bariatric Surgery
Glycemic control is rapidly restored in patients with insulin resistance after bariatric surgery, in particular after the mal-absorptive one (i.e. Bilio-pancreatic diversion, BPD).
- Conditions
- Insulin Resistance, Proteomics, Morbid Obesity
- Trial name
- PROTOBESE (NCT01151917)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
Pancreas Atrophy, Diabetes
Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas
Whilst there is an increasing prevalence of overweight and obesity worldwide, malnutrition remains common. In addition, malnutrition, overweight, and infections often interact.
- Conditions
- Pancreas Atrophy, Diabetes, Malnutrition
- Trial name
- SAMPA (NCT05361148)
- Testing
- no interventions will be used
- Where
- 4 sites in India, Philippines and 2 more
- Volunteers
- 2,305 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Healthy
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite…
- Trial name
- AFC-SPICES (NCT02035241)
- Testing
- Spices 1, Spices 2, Spices 3
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Glucose Tolerance
Effect of Medicago Sativa on Oral Glucose Tolerance in Healthy Adults
Previous preclinical investigations have found that Medicago sativa promotes the decrease of glucose concentrations. To evaluate the acute effect of Medicago sativa administration on glucose tolerance, insulin secretion, and…
- Trial name
- NCT03714438
- Testing
- Medicago Sativa
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- University of Guadalajara
Type 2 Diabetes Mellitus
Efficacy Of Autologous Bone Marrow Derived Stem Cell Transplantation In Patients With Type 2 Diabetes Mellitus-2
The purpose of this study is to improve blood glucose control in Type 2 Diabetes mellitus patients.
- Trial name
- NCT01065298
- Testing
- stem cell transplantation
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Metabolic Syndrome, Hypertriglyceridemia
Niacin, N-3 Fatty Acids and Insulin Resistance
This research study is being conducted to test the effects of two drugs on blood lipids (cholesterol and triglycerides) and blood sugar (glucose) levels in patients with diabetes or "pre-diabetes" (both of which have a condition…
- Trial name
- NCT00286234
- Testing
- omega-3 acid ethyl esters, extended release niacin, combined treatment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of South Dakota
Type 1 Diabetes
Overnight MD-Logic
Study design: Multicenter,randomized, prospective, open label, cross over, six segments, pilot trial to evaluate blood glucose control overnight under closed-loop insulin delivery with MD-Logic Artificial Pancreas (MDLAP) system…
- Trial name
- NCT01238406
- Testing
- MD-logic Artificial Pancreas (MDLAP), Standard treatment with insulin pump
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 151 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus Type 2
Economic Outcomes of EQW (Exenatide Once Weekly) vs. IG (Insulin Glargine) in T2D Patients Who Are New to Injectable Therapy
Primary objective of this study is to compare diabetes-related healthcare utilization and costs in patients initiating exenatide once weekly vs insulin glargine.
- Trial name
- NCT02843399
- Where
- United States
- Volunteers
- 15,498 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Post-prandial Glucose and Insulin Levels in Type 2 Diabetes Mellitus Patients After Consumption of Ready-to-eat Mixed Meals
The aim of the current study was to compare the effects of three ready-to-eat mixed meals, with a high fiber content and low glycemic index, on postprandial glycemic and insulinemic response in patients with Type 2 diabetes…
- Trial name
- NCT02543684
- Testing
- ready to eat mixed meal 1, ready to eat mixed meal 2, ready to eat mixed meal 3
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- Harokopio University
Diabetes
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ryzodeg®
This trial is conducted in Asia. The aim of this Non-interventional study is to investigate the long-term safety and effectiveness of Ryzodeg® (insulin degludec/insulin aspart) in Japanese patients with diabetes mellitus…
- Trial name
- NCT02821052
- Testing
- insulin degludec/insulin aspart
- Where
- Japan
- Volunteers
- 1,355 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Glycemic Control and the Brain in Children With Type 1 Diabetes
The purpose of this study is to determine if improving diabetes control by better controlling blood sugars, will help improve or normalize brain function as compared to routine diabetes care.
- Trial name
- NCT03428932
- Testing
- Closed Loop (Medtronic 670G), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Type 2 Diabetes Mellitus
Efficacy of Structured Insulin Order
The purpose of this study is to determine whether an electronic order template for basal-bolus insulin will improve mean blood glucose in hospitalized general medical patients with poorly controlled type 2 diabetes.
- Trial name
- NCT01130558
- Testing
- Diabetes Management
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Massachusetts General Hospital
Obesity, Hypertension
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug…
- Conditions
- Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT00675987
- Testing
- losartan
- Where
- 9 sites in United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Type1 Diabetes
Safe Use of New Technologies in Diabetes in Flight
Atmospheric pressure can influence how the body handles blood glucose. At high elevations, atmospheric pressure decreases. Research shows that both the elevation and the length of stay at that elevation can influence the body's…
- Trial name
- SUNDIF (NCT06408558)
- Testing
- Hypobaric, Ground level
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Surrey
Diabetes Mellitus, Type 1
Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes
A study to test for non-inferiority of preprandial HIIP [also known as AIR® Inhaled Insulin Powder][AIR® is a registered trademark of Alkermes,Inc.] compared with preprandial injectable insulin (insulin lispro) with respect to…
- Trial name
- NCT00356109
- Testing
- Human Insulin Inhalation Powder, Injectable insulin, Insulin Glargine
- Where
- 37 sites in United States, Argentina and 7 more
- Volunteers
- 494 people
- Sponsor
- Eli Lilly and Company
Myocardial Infarction
Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction
Stress hyperglycemia during myocardial infarction (MI) is related to mortality at short and long term. Recent studies, however, revealed that chronic statin treatment may decrease both insulin sensitivity and secretion…
- Trial name
- NCT01205347
- Testing
- Simvastatin 80mg, Simvastatin 10mg
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Brasilia Heart Study Group
Diabetes Mellitus
Pharmacist-driven CGM Use in the Uninsured Population
This is a pilot study. The purpose is to (1) provide access to continuous glucose monitoring (CGM) to patients (purchased through a grant) and (2) systematically record and analyze the results of the glucose monitoring by the…
- Trial name
- NCT03477838
- Testing
- FreeStyle LibrePro CGM
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Type 2 Diabetes
Safety and Efficacy Study of Metaglidasen in Type 2 Diabetes in Patients Suboptimally Controlled on Insulin
This is a multicenter, randomized, double-blind, placebo- and active comparator-controlled phase 2/3 study of three dose levels of MBX-102 (200, 400, 600 mg) given orally to patients with type 2 diabetes receiving concomitant…
- Trial name
- NCT00353587
- Testing
- MBX-102, Actos
- Where
- 67 sites in United States, Argentina and 2 more
- Volunteers
- 396 people
- Sponsor
- Gilead Sciences
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