Clinical trials: Insulin, completed
Sarcopenia
Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men
Rationale: Age related muscle loss (sarcopenia) is assumed to be related to the impaired postprandial muscle protein synthetic response to protein and/or amino acid administration in the elderly vs the young.
- Trial name
- PRO-CARB (NCT01576848)
- Testing
- Protein, Protein + carbohydrate
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asthma, Diabetes Mellitus
A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
This study will compare the rate and extent of absorption of TI Inhalation Powder in subjects with asthma and subjects with normal lung function. 24 eligible subjects will be enrolled into the treatment phase of the trial.
- Trial name
- NCT00673621
- Testing
- Technosphere Insulin Inhalation Powder, Salbutamol (Albuterol), Methacholine chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Hyperglycemia
Resistant Starch on Glucose and Insulin Sensitivity in Individuals With Type 2 Diabetes
This study will test the effects of resistant starch type 4 on blood sugar and hunger in adults with Type 2 diabetes.
- Trial name
- NCT00691249
- Testing
- Resistant Starch Type 4-Raw, Resistant Starch Type 4-Cooked, Shredded Wheat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kansas State University
Obesity, Insulin Resistance
Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
The purpose of this study is to investigate the changes in subcutaneous adipocyte size, number and gene expression after weight loss and to assess whether those changes contribute to decreases in ectopic fat accumulation and…
- Trial name
- NCT01901978
- Testing
- Caloric restrictive diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Type 1 Diabetes Mellitus
Diabetes Control and Complications Trial (DCCT)
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM).
- Trial name
- NCT00360815
- Testing
- Insulin
- Where
- 38 sites in United States, Canada
- Volunteers
- 1,441 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Healthy
Comparison of Insulin Aspart Produced by Current Process and the NN2000 Process
This trial is conducted in Europe. The aim of this trial is to compare insulin aspart produced by current process and the NN2000 process.
- Trial name
- NCT01486914
- Testing
- insulin aspart
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Novo Nordisk A/S
Non-alcoholic Fatty Liver Disease
Effect of Phytosterols on Nonalcoholic Fatty Liver Disease
Phytosterols are plant sterols . Phytosterols have anti-inflammation effect. Investigators have a hypothesis: phytosterols reduce oxidative stress , enhance Insulin-like growth factor-1(IGF-1) and endothelial progenitor…
- Trial name
- NCT01875978
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
New Frontiers on Bariatric Surgical Procedures: Classical Bypass for Type-2 Diabetic Patients With Obesity Grade I
Bariatric surgery leads to remission of type 2 diabetes in morbid obese patients in 80% (Roux-en-Y gastric bypass)to 90% (biliopancreatic diversion and duodenal switch) of cases.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566189
- Testing
- Roux-en-Y Bypass Gastroplasty
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Insulin Resistance, Atherosclerosis
The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans
The purpose of this study is to determine the health benefits of cranberry extract in people who are at risk for diabetes and heart problems.
- Trial name
- NCT02068144
- Testing
- Cranberry Extract
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus, Type 2
A Study of All-Cause and Cardiovascular Mortality in Type 2 Diabetes Patients Using Basal Insulin Detemir and Glargine
This study will examine the influence of the basal insulins detemir and glargine on risk of cardiovascular death and death from all causes in patients treated by their general practitioner in United Kingdom (UK).
- Trial name
- NCT03960814
- Testing
- Insulin detemir
- Where
- Denmark
- Volunteers
- 12,847 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
Comprehensive Postpartum Screening Strategies for Women With Gestational Diabetes Mellitus (GDM)
Previous gestational diabetes (GDM) predisposes affected women to diabetes. Pregnancy, in essence, serves as a metabolic stress test and uncovers underlying insulin resistance and ß-cell dysfunction.
- Trial name
- COPSS-GDM (NCT00849849)
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Woman's
Type 1 Diabetes Mellitus
Pilot Study Investigating the Feasibility of Determining the Endogenous Glucose Production During a Hypoglycaemia
Primary objective is to investigate the feasibility and stability of determining the endogenous glucose production during a hypoglycaemic clamp in type 1 diabetes mellitus subjects by a stable tracer to tracee ratio with an…
- Trial name
- PILOT_EGP (NCT02028078)
- Testing
- Insulin human
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Excessive Weight Gain in Pregnancy With Baby Delivered
The Blossom Project: "Be-Well" Behavioral Wellness Study in Pregnancy
Multiple studies have demonstrated a very low prevalence of women meeting physical activity and weight gain recommendations during pregnancy.
- Trial name
- Be-Well (NCT02168647)
- Testing
- Behavioral Lifestyle counseling, Control
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Type 2 Diabetes Mellitus
Left Ventricular Functional Changes of Uncontrolled Diabetes by Dapagliflozin Treatment Trial
The primary purpose of this study is to evaluate the efficacy of the SGLT2 inhibitor dapagliflozin, as compared with standard care of diabetes, on left ventricular (LV) structural and functional change in asymptomatic type 2…
- Trial name
- ELUCIDATE (NCT03871621)
- Testing
- Diabetes Medicines, Dapagliflozin
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Mackay Memorial Hospital
Heart Arrest, Cardiac Arrest
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest.
- Trial name
- NCT01968148
- Where
- 2 sites in Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Diabetes, Diabetes Mellitus, Type 1
Paediatric Subjects - Special Survey
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using insulin aspart in children with diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01538576
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0148-0000-0287 in Healthy Subjects
This trial is conducted in Europe. The aim of this first human dose trial is to investigate the safety, tolerability, pharmacodynamic (the effect of the investigated drug on the body) and pharmacokinetic (exposure of the trial…
- Trial name
- NCT01809184
- Testing
- insulin 287, insulin glargine
- Where
- Germany
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes
Defects in insulin secretion are central to the pathogenesis of type 2 diabetes (T2D) but the molecular basis and physiological consequences of those defects are poorly understood, impeding efforts to develop novel therapeutic…
- Trial name
- DIVA-Exeter (NCT02505308)
- Testing
- Glucose-Potentiated Arginine-Induced Insulin Secretion
- Where
- 2 sites in United Kingdom
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.