Clinical trials: Insulin
Type 1 Diabetes Mellitus
Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
This trial is designed to evaluate the effect of glucagon receptor antagonism by volagidemab (once weekly) on glucose recovery from hypoglycemia after treatment with glucagon in adults with type 1 diabetes.
- Trial name
- NCT06272695
- Testing
- Volagidemab
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- REMD Biotherapeutics, Inc.
High Intensity Interval Training, Diet, Healthy
Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy
Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of…
- Trial name
- NCT04830995
- Testing
- moderate restricted diet (1800-2000 kcal/day) for four weeks
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Type 1 Diabetes
Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus
type 1 diabetes is an autoimmune disease and still, some unknown mechanisms are undiscovered millions of children and adults suffer from this type which need basal-bolus insulin as the classical regimen, and basal-bolus insulin…
- Trial name
- NCT06057077
- Testing
- Semaglutide weekly injection
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Diabetes Mellitus Type 1
Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections to Reach HbA1c Targets in Children and Adolescents With Type 1 Diabetes
This study is to compare metabolic control, treatment satisfaction, and quality of life during continuous subcutaneous insulin infusion (CSII ) therapy with a new insulin pump system with multiple daily injections (MDI) therapy.
- Trial name
- Insight Kids (NCT02403375)
- Testing
- Accu-Chek Insight Pump System
- Where
- 9 sites in Austria, Germany and 1 more
- Volunteers
- 43 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 2
Do Group Insulin Education Visits Reduce Barriers to Insulin Initiation?
The purpose of this research is to determine if meeting in a group with other subjects with diabetes can reduce barriers to starting insulin.
- Trial name
- NCT00645528
- Testing
- Insulin Education Class
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- US Department of Veterans Affairs
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate Safety of Levemir® in Type 1 and Type 2 Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate the incidence of adverse events while using Levemir® under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00700765
- Testing
- insulin detemir
- Where
- Indonesia
- Volunteers
- 1,531 people
- Sponsor
- Novo Nordisk A/S
Common Wart
Sclerotherapy and Candida Antigen in Treatment of Common Warts
This study aims to evaluate the efficacy and safety of intralesional injections of candida antigen, polidocanol sclerotherapy and combined candida antigen with polidocanol in treatment of patients with common warts.
- Trial name
- NCT06749665
- Testing
- polidacanol 3%, candida antigen
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sohag University
Diabetes Mellitus, Type 2, Food Supply
Farming for Life - Health Impact of Organic Vegetable Prescriptions for Adults Living With or at Risk of Type 2 Diabetes
Farming for Life aims to determine the health impacts of providing weekly "prescriptions" of fresh organic vegetables to adults living with or at risk of type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Food Supply, Poverty, Minority Health
- Trial name
- FFL (NCT03940300)
- Testing
- Fresh organic vegetables
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Sansum Diabetes Research Institute
Hypercholesterolemia
Effects of Atorvastatin on Adiponectin Levels and Insulin Sensitivity In Hypercholesterolemic Patients
High dose atorvastatin may worsen insulin sensitivity.
- Trial name
- NCT00745836
- Testing
- statin
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Hyperprolactinemia, Insulin Resistance
Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated levels of Prolactin on metabolism and insulin sensitivity by studying patients with hyperprolactinemia before and after treatment.
- Trial name
- NCT00699530
- Testing
- Cabergoline
- Where
- Denmark
- Sponsor
- University of Aarhus
Obesity, Metabolic Syndrome
Genetics of Obesity in Chinese Youngs
The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.
- Trial name
- GOCY (NCT01084967)
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cardiovascular Diseases
Effects of the Mediterranean Diet on Cardiovascular Risk Profile in Men and Women
The purpose of this study is to document differences between men and women in changes in metabolic variables associated with cardiovascular risk in response to a 4 weeks isocaloric controlled nutritional intervention based on the…
- Trial name
- ALIMED (NCT01293344)
- Testing
- Controlled nutritional intervention based on the Mediterranean diet
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Diabetes Mellitus, Type 1
Steno Tech Explore: A Study of Insulin Pump Users With Type 1 Diabetes
The present study is part of an overarching study being conducted in Denmark at Steno Diabetes Center Copenhagen (SDCC) and Nordsjællands Hospital Hillerød (NOH), Steno Tech, that aims to develop and ultimately, in a randomized…
- Trial name
- NCT04311164
- Testing
- Questionnaire-based survey, No intervention given.
- Where
- 2 sites in Denmark
- Volunteers
- 770 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, With Complications
Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus
The purpose of this study is to determine if restoring normal metabolic function in patients with either type I or type II diabetes can improve the impact of the consequences of diabetic complications on the overall quality of…
- Trial name
- NCT00539409
- Testing
- Pulsatile Intravenous Insulin Therapy (Humulin R, Novolog)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Florida Atlantic University
Insulin Resistance
Efficacy Pilot Study of Triflusal in the Attenuation of Insulin Resistance in Human Obesity
To explore the efficacy of triflusal in the attenuation of insulin resistance in human obesity. Triflusal is a salicylate compound approved in several countries as antithrombotic agent (antiplatelet).
- Trial name
- NCT00162799
- Testing
- Triflusal (DCI)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- J. Uriach and Company
Gestational Diabetes Mellitus (GDM)
The Study of Recommendation System DiaCompanion for Women With Gestational Diabetes Mellitus
This is a randomized controlled trial of a recommendation system implementation in the treatment of women with gestational diabetes mellitus (GDM).
- Trial name
- NCT05179798
- Testing
- mobile app
- Where
- Russia
- Volunteers
- 216 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Diabetes Mellitus, Type 1
Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study
This is an investigator-initiated, prospective, randomized, multicenter, parallel, open-label, pilot clinical trial evaluating the efficacy of TI for PPBG, PPGE, and time-in-range on CGM download in patients with T1D.
- Trial name
- STAT (NCT03143816)
- Testing
- Technosphere insulin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
PCOS
Myoinositol vs. Metformin for Polycystic Ovarian Syndrome (PCOS): Impact on Metabolic Health and Fertility
The study aimed to assess how a 6-month insulin sensitizer therapy impacts insulin resistance, glucose tolerance, and hormonal levels in women with PCOS.
- Trial name
- NCT07058675
- Testing
- Metformin Hydrochloride 500 MG, Myoinositol
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Benha University
Type 1 Diabetes
Genome-wide Association Study of Different Types of Diabetes and Construction of Genetic Risk Score
To enhance the genetic profile of T1D patients in China and construct a Chinese-specific GRS and evaluated its ability to differentiate between T1D and controls, as well as between T1D and T2D.
- Trial name
- NCT06791330
- Volunteers
- 7,000 people
- Sponsor
- Second Xiangya Hospital of Central South University
Metabolic Syndrome
Acute Effects of Tocotrienols on Insulin Sensitivity and Metabolic Risk Markers in Individuals at Risk for Metabolic Syndrome
Objectives: To compare the acute effects of gamma delta rich tocotrienol fractions (gd-TRF) on insulin sensitivity, metabolic risk markers and postprandial lipemia in individuals at risk for metabolic syndrome.
- Trial name
- NCT01626430
- Testing
- Gamma delta TRF
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board