Clinical trials: Insulin
Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes
Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Glucocorticoids are known to cause an increase in insulin resistance, leading to hyperglycemia, in both diabetic and non-diabetic patients.
- Trial name
- NCT03511521
- Testing
- NPH Insulin, glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Spinal Cord Injuries
The Effects of Spasticity on Glucose Metabolism in Individuals With Spinal Cord Injury
Muscle atrophy may occur in individuals with spinal cord injury (SCI) as a result of diminished physical activity and alterations in glucose metabolism and body composition may be seen.
- Trial name
- NCT03859960
- Testing
- body composition, glucose, insulin, glycohemoglobin
- Volunteers
- 33 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes Under Free Living Conditions
The main objective of this study is to determine whether home use of day and night closed loop insulin delivery under free living conditions applying faster insulin aspart (FiAsp) is non-inferior to home use of closed-loop…
- Trial name
- AP@Home04_P3 (NCT04055480)
- Testing
- Closed-loop using standard rapid-acting insulin, Closed-loop using faster insulin aspart
- Where
- 4 sites in Austria, Switzerland and 1 more
- Volunteers
- 25 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 2
Management of Type 2 Diabetes After Gastric Bypass Surgery
Gastric bypass surgery has been proposed as an effective treatment strategy for type 2 diabetes mellitus (T2DM), but thus far algorithms for the management of T2DM immediately after surgery have not been established.
- Trial name
- NCT01213563
- Testing
- Actrapid insulin+Gloucose, Actrapid insulin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Diabetes, Diabetes Mellitus, Type 2
A Clinical Trial Comparing Glycaemic Control and Safety of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine (IGlar) as add-on Therapy to SGLT2i in Subjects With Type 2 Diabetes Mellitus
This trial is conducted globally. The aim of this trial is comparing glycaemic control and safety of insulin degludec/liraglutide (IDegLira) versus insulin glargine (IGlar) as add-on therapy to SGLT2i (sodium-glucose…
- Trial name
- DUALTM IX (NCT02773368)
- Testing
- insulin degludec/liraglutide, insulin glargine
- Where
- 88 sites in United States, Argentina and 9 more
- Volunteers
- 420 people
- Sponsor
- Novo Nordisk A/S
Pharmacokinetics, Bioequivalence
Comparative Study of Rinsulin® NPH, Suspension for Subcutaneous Administration, 100 IU/ml (GEROPHARM LLC, Russia) and Humulin® NPH, Suspension for Subcutaneous Administration, 100 IU/ml (Lilly France, France) Using the Euglycemic Hyperinsulinemic Clamp Method
Сomparative pharmacokinetic study of Rinsulin® NPH, suspension for subcutaneous administration, 100 IU/ml (GEROPHARM LLC, Russia) and Humulin® NPH, suspension for subcutaneous administration, 100 IU/ml (Lilly France, France)…
- Trial name
- NCT04501250
- Testing
- Rinsulin NPH, Humulin NPH
- Where
- Russia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Geropharm
Diabetes Mellitus, Type 1
A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to learn more about a new formulation of insulin lispro when given by an insulin pump to participants with type 1 diabetes mellitus.
- Trial name
- NCT04161976
- Testing
- LY900027, Insulin Lispro
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Tresiba®
This study is conducted in Asia. The aim of this post marketing surveillance (PMS) is to assess safety and effectiveness of long-term treatment with Tresiba® (insulin degludec) in patients with diabetes mellitus requiring insulin…
- Trial name
- NCT01984372
- Testing
- insulin degludec
- Where
- Japan
- Volunteers
- 6,163 people
- Sponsor
- Novo Nordisk A/S
Diabetic Nephropathy
Nephropathy In Type 2 Diabetes and Cardio-renal Events
The NID-2 study, a multicentric study (21 centres enrolled), was planned in two phases: Phase 1(observational study, completed in September 2005): after the identification of a type-2 diabetic population with typical Diabetic…
- Trial name
- NID-2 (NCT00535925)
- Testing
- SoC therapy, irbesartan, ramipril
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- University of Campania Luigi Vanvitelli
Tendinopathy
Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I
The purpose of the study is to test the hypothesis that stimulation of the synthesis of new structural tendon proteins combined with training improve the tendon structure in patients with chronic knee tendon pain.
- Trial name
- IGF-I (NCT01834989)
- Testing
- Insulin-like growth factor I
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Bispebjerg Hospital
Type 1 Diabetes
Immune Effects of Oral Insulin in Relatives at Risk for Type 1 Diabetes Mellitus (TN20)
The study is a 2 arm, multi-center, randomized, open-labeled clinical trial designed to assess the effects of varying doses and schedules of oral insulin on immunological and metabolic markers in relatives at risk for type 1…
- Trial name
- NCT02580877
- Testing
- 67.5 mg oral insulin crystals daily, 500mg oral insulin crystals every other week
- Where
- 19 sites in United States, Australia and 2 more
- Volunteers
- 92 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes
Artificial Intelligence Assisted Insulin Titration System
This is a single-center, open-labeled, parallel group, randomized controlled trial to access the effect and safety of the Artificial Intelligence Assisted Insulin Titration System in patients with Type 2 Diabetes Mellitus.
- Trial name
- iNCDSS (NCT04053959)
- Testing
- AI assisted insulin system, Physician based insulin regime
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Zhongshan Hospital
Gestational Diabetes
Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus
This study is a prospective, unmasked randomized clinical trial comparing the use of insulin vs combination insulin and metformin for treatment in women diagnosed with gestational diabetes mellitus (GDM).
- Trial name
- NCT03651531
- Testing
- Insulin, Metformin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Type1diabetes
New Insulin Therapy by Multiwave Bolus
The aim of the study is to evaluate the effect of insulin therapy when the bolus dose of insulin is calculated on the basis of protein and fat content in food intake, in addition to that of carbohydrates in T1D patients treated…
- Trial name
- EVANEWFIT2 (NCT03311516)
- Testing
- New functional insulin therapy, functional insulin therapy
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of GP40071 Compared to NovoRapid® Penfill® in Type 1 Diabetes Mellitus Patients
This trial is a multi-center, open-label, randomized, parallel group trial in adult patients with T1DM comparing the efficacy and safety of GP40071 (insulin aspart, GEROPHARM) with that of NovoRapid®.
- Trial name
- NCT04079413
- Testing
- GP40071, NovoRapid® Penfill®
- Where
- 14 sites in Russia
- Volunteers
- 264 people
- Sponsor
- Geropharm
Diabetes Mellitus, Type 2
A Research Study, Looking at How NovoMix® Works in People With Type 2 Diabetes in Local Clinical Practice in Algeria
The purpose of the study is to collect information about how NovoMix® 30 works in real world adult population with type 2 diabetes. Participants will get NovoMix® 30 as prescribed by the study doctor.
- Trial name
- B Simple (NCT03862690)
- Testing
- BIAsp 30
- Where
- 2 sites in Algeria
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Pharmacokinetics of Ultra-Rapid-Acting Insulin Lispro (URAL) in Type 1 Diabetes Mellitus
To compare the early pharmacokinetic exposure of URAL and insulin lispro (ILisp).
- Trial name
- NCT02206568
- Testing
- URAL
- Where
- Germany
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Diabetes Mellitus, Type 2
Effects of Insulin Glargine and Lixisenatide on the Brain
1. Background During the last years, the brain has been identified as a major insulin-sensitive organ . The investigators and also other scientists identified hypothalamus, fusiform gyrus and prefrontal cortex as major…
- Trial name
- Lixibrain01 (NCT03881995)
- Testing
- IGlarLixi, Insulin Glargine 100 UNT/ML
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus, Type 2
Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin
This study will compare hemoglobin a1c (HbA1c) and cardiovascular (CV) outcomes among patients with type 2 diabetes newly initiating a GLP1-receptor agonist or basal insulin.
- Trial name
- NCT04034524
- Testing
- GLP-1 receptor agonist, Insulin
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2
Using 32 - Gauge Needles With Lengths of 5 mm and 8 mm on Pain Post-injection, Leak and Blood Glucose
This is a Clinical crossover trial study. In this study, 100 patients with type II diabetes will be selected based on entry and exit criteria, then randomly divided into two equal groups (group "A" and group "B").In the first…
- Trial name
- NCT04460092
- Testing
- 5-mm 32-gauge Insulin needles in the first three days of Intervention, 8-mm 32-gauge Insulin needles in the first three days of Intervention, 5-mm 32-gauge Insulin needles in the last three days of Intervention
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Baqiyatallah Medical Sciences University