Clinical trials: Insulin, completed
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Hypoglycaemia
Recurrent Hypoglycaemia in Type 1 Diabetes
Patients with type 1 diabetes are at risk of very low blood sugar levels (hypoglycaemia) as a severe side effect to insulin therapy, in particular subjects who have lost warning of hypoglycaemia.
- Trial name
- HypoNeuro (NCT01337362)
- Testing
- Insulin clamp
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Hillerod Hospital, Denmark
Type 1 Diabetes, Type 1 Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Hyperglycemia, Postprandial
- Trial name
- NCT04163874
- Testing
- Fiasp, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University
Prostate Cancer
Prospective Study of Insulin Resistance and Cardiovascular Disease Risk During Androgen Deprivation Therapy for Prostate Cancer
The purpose of this study is to find out if androgen deprivation therapy affects insulin, cardiac risk factors such as cholesterol level, and body fat and muscle.
- Trial name
- NCT00455624
- Testing
- Androgen deprivation therapy
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Obesity, Diabetes
Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
The primary aim of our study was to examine the effects of two weeks of oral resveratrol on resting energy expenditure and insulin sensitivity in non-diabetic obese male subjects.
- Trial name
- NCT02247596
- Testing
- Resveratrol
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Khoo Teck Puat Hospital
Diabetes Mellitus, Type 1
Flexible, Intensive Insulin Therapy in Patients With Type 1 Diabetes
To prospectively evaluate the long term metabolic and psychological effects of flexible intensive insulin therapy (FIT) courses in an unselected population of type 1 diabetic patients at the University of Basel Hospital.
- Trial name
- NCT00595569
- Testing
- Flexible insulin therapy (FIT)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Lausanne Hospitals
Metabolic Syndrome X, Inflammation
Effect of Dietary Flavonoids on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome
The investigators have hypothesized that dietary flavonoids reduce insulin resistance and subclinical inflammation secondary to reductions in intestinal inflammation and permeability and that these events are mediated through…
- Trial name
- NCT02728570
- Testing
- High Dietary Flavonoids, Low Dietary Flavonoids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Utah State University
Type 2 Diabetes Mellitus, Multiple Dose Insulin Therapy
Application of a Protocol of Personalized Medicine in Patients With Type 2 Diabetes Mellitus and Multiple Doses of Insulin in Routine Clinical Care
The goal of this observational study is to test a protocol of personalized medicine in routine clinical practice in people with type 2 diabetes (T2DM) treated with multiple dose insulin injections (MDI).
- Trial name
- POMA (NCT06148376)
- Testing
- Personalized treatment
- Where
- 2 sites in Spain
- Volunteers
- 239 people
- Sponsor
- Hospital Arnau de Vilanova
Glucose Intolerance, Insulin Resistance
Iron and Insulin Resistance in Overweight and Obese Humans
Determine the effects of reducing whole-body iron stores in overweight/obese subjects (via one-time blood donation) on adipose tissue iron content, factors regulating iron homeostasis and lipolytic rate in adipose tissue, as well…
- Conditions
- Glucose Intolerance, Insulin Resistance, Iron Metabolism
- Trial name
- Fe (NCT03348020)
- Testing
- Blood Donation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus
Effectiveness of Phone Calls Intervention on Diabetic Patients After Ambulatory Discharge of a Tertiary Care Center
The study is a randomized clinical trial, controlled, open label that aimed to compare two groups after discharge of a tertiary care: type 2 diabetes patients followed exclusively by primary care (control group) and patients…
- Trial name
- NCT02768480
- Testing
- Primary Care, Phone Calls Support and Primary Care
- Where
- Brazil
- Volunteers
- 147 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Type1diabetes
Impact of the Continuous Measurement of Blood Glucose on Insulin Pump on Child Quality of Life With Type 1 Diabetes
The implementation of a sensor of glycemia Enlite coupled with an insulin pump (Medtronic Minimed 640G) is a therapeutic option that Hospital of Mulhouse can propose to the children affected by type 1 diabetes.
- Trial name
- IM-CAPT (NCT03177096)
- Testing
- Peds QL questionnaire and diabetes modulate, WHO-5 questionnaire, Felt questionnaire
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Diabetes, Diabetes Mellitus, Type 2
Effectiveness and Safety of Biphasic Insulin Aspart 70/30 in Subjects With Type 2 Diabetes
This trial is conducted in Asia. This is a clinical trial investigating the effectiveness of using Biphasic Insulin Aspart 70/30 in two different treatment regiments for 6 months in subjects with type 2 diabetes, not well…
- Trial name
- NCT00184561
- Testing
- biphasic insulin aspart
- Where
- 8 sites in China
- Volunteers
- 321 people
- Sponsor
- Novo Nordisk A/S
Eating Disorder, Type 1 Diabetes
Support Group Surveys for Individuals Who Have Type 1 Diabetes and an Eating Disorder
We propose to conduct a monthly group of persons with type 1 diabetes who also withhold insulin. Subjects will be asked to complete a 2-page survey (check-in sheet) at the beginning of each session and a 5-page survey (Diabetes…
- Trial name
- NCT00818142
- Testing
- ED/DM Support Group
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Type 2
A Study to Determine the Safety and Efficacy of Albiglutide Administered in Combination With Insulin Glargine
This study will examine the safety and efficacy of albiglutide in combination with insulin glargine as compared with the combination of insulin glargine and preprandial lispro insulin in subjects with type 2 diabetes.
- Trial name
- NCT00976391
- Testing
- albiglutide + insulin glargine, insulin glargine + preprandial lispro insulin
- Where
- 209 sites in United States, Brazil and 12 more
- Volunteers
- 586 people
- Sponsor
- GlaxoSmithKline
Obesity, Insulin Resistance
Role of Adipose Tissue in Pathogenesis of Insulin Resistance
The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines.
- Trial name
- NCT00439491
- Testing
- Hypocaloric diet
- Where
- Czechia
- Volunteers
- 35 people
- Sponsor
- Charles University, Czech Republic
Healthy
Metabolic Effect of High-protein Meals in Men
The purpose of the clinical study is to investigate the effect of the protein quality of high-protein meal replacements on the management of post-prandial blood glucose in healthy men.
- Trial name
- OPTI-PROT (NCT00712010)
- Testing
- Whey protein native, Whey protein microgels, Hydrolyzed whey protein
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Prevention, Obesity Prevention
PERFECT Project - Part 2 - Study 2
The objectives are to test the acute effects of different cereals containing pulse ingredients on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite to an aerobic…
- Trial name
- NCT02370927
- Testing
- Control, Pea protein, Pea Starch
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Insulin Sensitivity
Modulation of Insulin Sensitivity by Betaine Upregulation of FGF21
People with poor insulin sensitivity do not respond normally to elevations in blood sugar. This may increase their risk of developing diabetes in the future.
- Trial name
- NCT02118142
- Testing
- Betaine, Dextrose
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Pre-frail Elderly
The Effect of Cholecalciferol in Pre-frail Elderly
Vitamin D plays important role in musculoskeletal health and has been known to influence immune system. Inflammaging is one of risk factors that may contribute to development of frailty in elderly.
- Trial name
- NCT04847947
- Testing
- Cholecalciferol
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Type 1 Diabetes, Type 2 Diabetes
Efficacy, Safety and Satisfaction of the New Pen Needle 33 Gauge x 4 mm.
During the last years, even more little needles are used for the injection of sub cutaneous insulin, for the diabetes therapy. The aim of this study is to evaluate the non inferiority of a new needle, smaller than another needle…
- Trial name
- AGO01 (NCT01745549)
- Testing
- Needle for insulin pen, 4 mm long and with a diameter of 33 gauge, Needle for insulin pen, 4 mm long and with a diameter of 32 gauge
- Where
- 4 sites in Italy
- Volunteers
- 87 people
- Sponsor
- Consorzio Mario Negri Sud
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