Clinical trials: Itraconazole
Heart Failure With Preserved Ejection Fraction (HFpEF)
A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers
This is an open-label, non-randomized, fixed sequence study conducted at a single study center with primary aim to assess the pharmacokinetics (PK) of AZD9977 in healthy volunteers when administered alone and in combination with…
- Trial name
- NCT03843060
- Testing
- AZD9977, Itraconazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study To Evaluate The Effect Of Rifampicin Or Ltraconazole On Pharmacokinetics Of Ensartinib In Healthy Volunteers
The purpose of this study is to estimate the effect of rifampicin or itraconazole on the single dose PK of ensartinib.
- Trial name
- NCT06492525
- Testing
- Ensartinib, Rifampicin, Itraconazole
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Invasive Fungal Infections
Endemic Mycoses Treatment With SUBA-itraconazole vs Itraconazole
This is a prospective, multi-center, randomized, open-label parallel arm study involving patients with proven or probable invasive endemic fungal infection to ascertain the pharmacokinetics, safety, efficacy, tolerability and…
- Trial name
- MSG15 (NCT03572049)
- Testing
- SUBA itraconazole, Conventional itraconazole
- Where
- 12 sites in United States, Panama
- Volunteers
- 88 people
- Sponsor
- University of Alabama at Birmingham
Not Determined
A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers
This is a single-center, open-label, parallel group study designed to investigate the effect of CYP3A induction and inhibition following multiple doses of phenytoin (Part A) and itraconazole (Part B), respectively, on the…
- Trial name
- NCT06543043
- Testing
- Phenytoin, Itraconazole, sonrotoclax
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BeiGene
Antifungal Drugs in Onychomycosis
Antifungal Drugs in Treatment of Onychomycosis
Onychomycosis refers to the fungal infection of the fingernails or toenails, caused by dermatophytes, yeast and non-dermatophyte molds that lead to distortion, discoloration, thickening and detachment from the nail bed
- Trial name
- NCT03171584
- Testing
- Terbinafine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Coccidioidomycosis, Valley Fever
SUBA-Itraconazole Therapy for Coccidioidomycosis Refractory or Intolerant to Fluconazole
The purpose of this study is to determine how safe, effective, and well tolerated a new investigational antifungal drug, SUBA-itraconazole, is for patients who have been previously treated with fluconazole and have had either an…
- Trial name
- SITRIS (NCT04809649)
- Testing
- SUBA-itraconazole
- Where
- United States
- Sponsor
- George R Thompson
Mycetoma
Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan
This study is a single-center, comparative, randomized, double-blind, parallel-group, active-controlled, clinical superiority trial of Fosravuconazole versus Itraconazole combined with surgery in subjects with eumycetoma in…
- Trial name
- NCT03086226
- Testing
- Fosravuconazole, Itraconazole
- Where
- Sudan
- Volunteers
- 104 people
- Sponsor
- Drugs for Neglected Diseases
Systemic Fungal Infections
Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents
This multicenter observational cohort study proposes to establish the risks of short and long-term outcomes in users of parenteral micafungin and in users of other parenteral antifungal agents from 2005 through 2012 with…
- Trial name
- MYCOS (NCT01686607)
- Testing
- Parenteral micafungin application, Other parenteral antifungal drugs
- Where
- 6 sites in United States
- Volunteers
- 40,110 people
- Sponsor
- Astellas Pharma Europe B.V.
Healthy
Clinical Study Aiming to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Administration of ZE50-0134 at 5 Dose Levels in Healthy Volunteers
A first-in-human study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses of ZE50-0134 administered orally in healthy volunteers.
- Trial name
- NCT06787131
- Testing
- Rabeprazole 20 mg, Itraconazole (200 mg)
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Lomond Therapeutics Holdings, Inc.
Healthy
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1815368 in the Blood
The main objective of this trial is to investigate the effect on the exposure of BI 1815368 in plasma when given as oral single dose together with multiple oral doses of itraconazole (Test, T) as compared to when given alone as…
- Trial name
- NCT05965583
- Testing
- BI 1815368, Itraconazole
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Basal Cell Carcinoma
Topical Itraconazole in the Treatment of Basal Cell Carcinoma
This research is being done to study the molecular effects of topically applied itraconazole ointment on the growth of basal cell carcinomas.
- Trial name
- NCT02120677
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Healthy
A Drug Interaction Study of ACH-0145228
This was a 2-part study (Part 1 and Part 2), with each part being an open-label, fixed sequence, 2-period study in healthy adult participants.
- Trial name
- NCT04709081
- Testing
- ACH-0145228, Midazolam, Digoxin
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Healthy Volunteers
Study of BIIB091 Formulations in Healthy Participants
The primary objectives of this study are: to evaluate the pharmacokinetic (PK) profiles of BIIB091 modified release (MR) formulations in healthy participants after single dose administration in the fasted state (Part 1); to…
- Trial name
- NCT04564612
- Testing
- BIIB091, Rabeprazole, Itraconazole
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Biogen
Japanese Healthy Adult Males
Drug-Drug Interaction Study Between TAK-272 and Itraconazole, Digoxin or Midazolam
The purpose of this study is to evaluate the effect of repeated-dose administration of itraconazole on the pharmacokinetics of TAK-272, as well as the effect of repeated-dose administration of TAK-272 on the pharmacokinetics of…
- Trial name
- NCT02370615
- Testing
- TAK-272, Digoxin, Itraconazole
- Where
- Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Volunteers
A Study of RO7890597 in Healthy Adult Volunteers
This study will evaluate the safety, pharmacokinetics (PK), and activity of single and multiple doses of RO7890597 compared with placebo in healthy volunteers.
- Trial name
- NCT07797478
- Testing
- RO7890597, Rabeprazole, Itraconazole
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Subjects
Effect of Itraconazole on the Pharmacokinetics of Pyrotinib in Healthy Subjects
The study will assess the effect of multiple oral doses of itraconazole on the single dose pharmacokinetic parameters of pyrotinib in healthy Chinese subjects.
- Trial name
- NCT04479891
- Testing
- pyrotinib tablet, Itraconazole capsule
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Tinea Corporis, Tinea Cruris
Efficacy and Safety of Terbinafine and Itraconazole
There is a rise in the prevalence in recent years especially in tropical countries along with an increase in the number of treatment failures with chronic and recurrent dermatophytosis.
- Conditions
- Tinea Corporis, Tinea Cruris, Tinea Faciei, Dermatophytoses
- Trial name
- NCT05881980
- Testing
- Terbinafine Tablets, Itraconazole
- Volunteers
- 150 people
- Sponsor
- Dhaka Medical College
Healthy
Study That Evaluates the Effect of CYP3A4 Inhibition on Lu AG06466 in Healthy Men and Women
A study to learn how a drug (itraconazole) that is known to inhibit a certain enzym in the liver, impacts the body's ability to breakdown Lu AG06466 into breakdown products in healthy men and women.
- Trial name
- NCT04405323
- Testing
- Lu AG06466, Itraconazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Achlorhydria
Study to Evaluate Effects of Food or Proton Pump Inhibitor on the Pharmacokinetics of Itraconazole in Healthy Volunteers
The aim of this study is to evaluate the effects of food or proton pump inhibitor on the pharmacokinetics of itraconazole in healthy volunteers.
- Trial name
- NCT04942652
- Testing
- Itraconazole 200 mg, Esomeprazole 40 mg
- Where
- South Korea
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Volunteers, Pharmacokinetics of ASP3700
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP3700 in Healthy Male Subjects
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics (PK) of single ascending oral doses of ASP3700 in healthy male subjects.
- Trial name
- NCT02155504
- Testing
- ASP3700, itraconazole
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.