Clinical trials: Ketamine
Healthy
A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants
The primary purpose of the study is to evaluate the pharmacokinetics (what the body does to the medication) of intranasally (through the nose) administered esketamine in healthy participants.
- Trial name
- NCT01780259
- Testing
- Esketamine, Triazolam
- Where
- Belgium
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Ketamine-Induced Brain Activity Changes, Psychotic-like Symptoms
Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults
The purpose of this study is to determine whether ketamine-induced brain activity changes are modulated by TAK-063 administration using neuroimaging battery tests.
- Trial name
- NCT01892189
- Testing
- Ketamine, TAK-063
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Takeda
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Circadian Rhythm, Postoperative Sleep Disturbance
Effect of Esketamine on Postoperative Sleep in Postmenopausal Women
The prevalence of sleep disturbance among postmenopausal women has been reported to reach 51.6%. Epidemiological studies consistently show that the incidence of sleep disorders increases with age and menopausal transition.
- Trial name
- NCT07315074
- Testing
- Esketamine, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 164 people
- Sponsor
- Zhuan Zhang
Umbilical Hernia, Spinal Aneshtesia
Spinal Or General Anesthesia For Umblical Hernia Surgery
In this study, the investigators compared spinal anesthesia under ketofol (ketamine-propofol combination) sedation with general anesthesia in terms of intraoperative and postoperative hemodynamics, respiratory parameters and cost…
- Conditions
- Umbilical Hernia, Spinal Aneshtesia, General Anesthesia
- Trial name
- NCT06426225
- Testing
- General Anesthesia, Spinal Aneshtesia
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia
Opioid Free Anesthesia: What About Patient Comfort?
66 female patients undergoing breast cancer surgery were randomized in the Jules Bordet Institute, the Belgian oncology institute. One group received an opioid anesthesia, the other group an opioid free one.
- Trial name
- NCT02882035
- Testing
- OFA
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Université Libre de Bruxelles
Healthy
The Effects of Low Dose Ketamine on Cardiovascular Function
Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure.
- Trial name
- NCT04429685
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
The Effect of S-ketamine on Pharmacokinetics of Morphine, Hydromorphone, and Buprenorphine
KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
S-ketamine is often administered as a part of multimodal analgesia to reduce postoperative pain and postoperative opioid consumption.
- Trial name
- KetaMoHydBup (NCT05571176)
- Testing
- S-ketamine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Elina Brinck
Anesthesia
Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?
To compare between fentanyl group and ketamine lidocaine group for induction of anesthesia as regards hemodynamics and smooth intubation.
- Trial name
- NCT03806374
- Testing
- Ketamine, Propofol, Fentanyl
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bolus Versus Infusion Ketamine, Anesthesia Gas Consumption
Comparison of BIS Index Variations: Bolus Versus Infusion Ketamine, and Impact on the Anesthesia Gas Consumption
The aim of the present study is to show that i.v. ketamine boluses might lead to significant and clinically relevant BIS index increase that might lead to an increase in anesthesia dosing (halogenous gas) when compared to an i.v.
- Trial name
- KETABIS (NCT03781635)
- Testing
- bolus of intravenous ketamine, continuous infusion of intravenous ketamine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Multiple Sclerosis, Fatigue
Ketamine for Treatment of MS Fatigue
Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disease of the central nervous system and, after trauma, is the most common cause of disability in young adults, affecting more than 400,000 individuals…
- Trial name
- NCT03500289
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Postoperative Pain, Total Abdominal Hysterectomy
Dexmedetomidine Versus Ketamine in TAP Block for Postoperative Analgesia After Total Abdominal Hysterectomy
Total abdominal hysterectomy is associated with significant postoperative pain due to abdominal wall incision and tissue manipulation.
- Trial name
- NCT07845643
- Testing
- TAP block using Dexmedetomidine & Bupivacaine, TAP block using Ketamine Hydrochloride and Bupivacaine
- Where
- Bangladesh
- Volunteers
- 64 people
- Sponsor
- Bangladesh Medical University
Inguinal Hernia
Effects of Esketamine at Subanesthetic Dose on Emergence Delirium in Preschool Children Undergoing Ambulatory Laparoscopic Surgery
Emergence delirium (ED) is a manifestation of acute postoperative brain dysfunction that occurs with a relatively high frequency after pediatric anesthesia.
- Trial name
- NCT06789185
- Testing
- 0.1mg/kg esketamine, 0.2mg/kg esketamine, 0.1ml/kg normal saline
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qiu jinpeng
Delirium
Preventative Delirium Protocol in Elderly Patients
The current study aims to elucidate the effectiveness of a preventative delirium protocol in patients older than 65 years of age undergoing elective surgery.
- Trial name
- NCT03541408
- Testing
- Control, Preventative Delirium Protocol
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Ketamine-Induced Psychotic Disorder, Social Cognition
Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers
Antipsychotic medication shows generally good effect sizes when looking at reduction of positive psychotic symptoms of schizophrenia, such as paranoia or delusion.
- Conditions
- Ketamine-Induced Psychotic Disorder, Social Cognition, Theory of Mind
- Trial name
- METAKETAII (NCT05320991)
- Testing
- Ketamine, Nacl 0.9%
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Postoperative Nausea and Vomiting
Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery
Morbidly obese patients are at high risk for Postoperative Nausea and Vomiting (PONV) after surgery and general anesthesia. The results of our observational study indicate that 42.7% of patients require medication to treat PONV…
- Trial name
- NCT01449708
- Testing
- TIVA NoNarc
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Coastal Anesthesiology Consultants
Acute Pain, Chronic Pain, Widespread
Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain
This is a clinical trial that intend to determine the effects of S-ketamine on event-related potentials associated with semantic affective pain-processing
- Conditions
- Acute Pain, Chronic Pain, Widespread, Schizophrenia
- Trial name
- NCT03915938
- Testing
- Ketamine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression
Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life
The goal of this exploratory, mixed-method design study is to gather qualitative and quantitative data obtained through interviews and questionnaires with veterans who are currently enrolled at the VA for healthcare.
- Trial name
- KAP (NCT06824532)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Albany Research Institute, Inc.
Major Depressive Disorder
Ketamine in Adolescents With Treatment-Resistant Depression
This study will test the use of ketamine for treatment of depression in adolescents that have not responded to other treatments. We will also examine neurobiological mechanisms of treatment.
- Trial name
- NCT02078817
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Trauma, Pain
Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients
Often, patients transported by aeromedical systems do not receive enough medication to control and relieve their pain. The purpose of this study is to determine if pain treatment with intravenous (IV) ketamine is a better way to…
- Trial name
- NCT01169025
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Sponsor
- University of Utah