Clinical trials: Ketamine
Intubation
Opioid-free Analgesia in Intensive Care Unit
ICU patients experience moderate to severe pain. Studies and guidelines point out the benefits of multimodal analgesia on pain control, opioid spare and on lowering its adverse effects.
- Trial name
- OFICU (NCT05825560)
- Testing
- OFA multimodal analgesia, Standard multimodal analgesia
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ketamine, Morphine
PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery
The goal of this clinical trial is to compare the effectiveness of PCA ketamine-morphine versus conventional PCA morphine in postoperative patients undergoing elective laparotomy colorectal surgery under general anaesthesia.
- Trial name
- NCT06021717
- Testing
- Ketamine-Morphine, Morphine
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Pain, Postoperative
The Effect of Gabapentin, Ketamine and Dexamethasone on Pain and Opioid Requirements After Hip Surgery
Patients scheduled for primary hip replacement needs postoperative pain treatment, i.e. morphine. Morphine has side-effects: nausea, vomiting, sedation and dizziness.
- Trial name
- NCT00236223
- Testing
- Gabapentin + dexamethasone + ketamine
- Where
- 2 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Post Operative Pain
Efficient Postoperative Pain Management With Multimodal IV
Postoperative pain remains a prevalent concern despite ongoing improvements in surgical methods and pain management strategies. Opioids, while commonly prescribed, frequently lead to undesirable side effects.
- Trial name
- NCT06661746
- Testing
- Multimodal IV analgesia, epidural analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Acute Stress Disorder
Micro-Dose, Macro-Impact: Leveraging Psychedelics in Frontline Healthcare Workers During the COVID-19 Pandemic
A retrospective chart review of an open-label trial of low-dose ketamine administered to front-line Healthcare workers who were identified as experiencing acute stress disorder due to the COVID-19 Pandemic.
- Trial name
- NCT04769297
- Testing
- Sublingual Micro-Dose Ketamine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Limbic Medical
Major Depressive Disorder, Treatment Resistant Depression
Ketamine Augmentation of ECT in Treatment-Resistant Depression
This is a randomized, double-blind, placebo-controlled phase 3 clinical trial evaluating the additive effect of intravenous ketamine in combination with electroconvulsive therapy (ECT) in patients with treatment-resistant major…
- Trial name
- Ketamina (NCT07088380)
- Testing
- Ketamine Hydrochloride
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Vita-Salute San Raffaele
Pain, Postoperative
Ketamine Effects as Preemptive Analgesia
The goal of this randomized controlled trial is to compare the effect of preemptive ketamine administration to placebo administration in patients underwent hysterectomy surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT06040060
- Testing
- Ketamine
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran
Treatment-Resistant Depression, Major Depressive Disorder
Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
An observational-comparative study, without interfering with the treatment, based on an operationalized interview.
- Trial name
- NCT06232291
- Where
- Poland
- Volunteers
- 3 people
- Sponsor
- Medical University of Gdansk
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Postoperative Pain
Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute…
- Trial name
- NCT07063108
- Testing
- Esketamine hydrochloride, Saline
- Volunteers
- 276 people
- Sponsor
- Chinese PLA General Hospital
Major Depressive Episode
Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients
Unipolar major depressive disorder is the leading cause of disability worldwide. The most commonly used treatments for major depressive episodes (MDE) are antidepressant medications.
- Trial name
- MOODBOOSTER (NCT06508710)
- Testing
- Ketamine
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trauma, Rapid Sequence Intubation
Prospective Study of Induction Medications Used in the Trauma RSI
To compare the outcomes of the use of propofol, etomidate, and ketamine as induction agents for adult trauma patients undergoing intubation within 24 hours of admission.
- Trial name
- ProTIM (NCT04291521)
- Testing
- Ketamine, Etomidate, Propofol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Morbid Obesity
Effect of Oxalidine Combined with Reduced-opioid Anesthesia on Multimodal Analgesia in Morbidly Obese Patients Undergoing Bariatric Surgery
The goal of this study is to elucidate the efficacy and safety of oxelidine combined with oligopiate anesthesia for multi-modal analgesia in weight-loss surgery in morbidly obese patients, and to discover a new strategy for…
- Trial name
- NCT06712199
- Testing
- oxalidine
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Yongtao Sun
Dentofacial Deformities, Analgesia
Effects of Local Ketamine in Orthognathic Procedures
Orthognathic surgery is performed to correct congenital, developmental, or trauma-related skeletal deformities of the maxilla and mandible.
- Conditions
- Dentofacial Deformities, Analgesia, Vomiting, Postoperative, Nausea, Postoperative
- Trial name
- NCT07066306
- Testing
- Ketamine, Articaine Hydrochloride + Epinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Laparoscopic Cholecystectomy, Alleviate Postoperative Fatigue Syndrome
Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (LC), although minimally invasive, is frequently associated with postoperative fatigue syndrome (POFS), which can delay recovery and prolong convalescence.
- Trial name
- NCT07131033
- Testing
- Esketamine, Magnesium sulfate, Esketamine and Magnesium sulfate
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The Second People's Hospital of Huai'an
Rotator Cuff Injuries, Anesthesia, General
Comparison of Two General Anesthesia Maintenance Strategies on Intraoperative Visibility During Arthroscopic Rotator Cuff Surgery: A Randomized Trial
Shoulder arthroscopy is one of the most common orthopedic procedures, and the quality of the surgeon's view inside the joint is critical to its safety and success.
- Conditions
- Rotator Cuff Injuries, Anesthesia, General, Arthroscopy
- Trial name
- CLEAR-SHOULDER (NCT07628244)
- Testing
- Inhalation anesthesia, Continuous intravenous anesthesia
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy
A Blinded, Four-Way Crossover in Healthy Subjects to Assess EEG After Administration of Ketamine, Placebo and AZD6765
This study will provide data to support preclinical to clinical translation by aligning preclinical and clinical efficacy assay with dose dependent changes in EEG.
- Trial name
- AZD6765 EEG (NCT01130909)
- Testing
- AZD6765, Ketamine
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Duration of Hospitalization in Intensive Care Unit
Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
Currently intravenous analgesics are used for postoperative analgesia. But the analgesia of these products is tempered by their adverse effects (sedation, confusion, nausea or vomiting, delayed transit, urinary retention and…
- Trial name
- PARALSTER (NCT06463899)
- Testing
- multi-perforated catheter, Classic procedure
- Where
- France
- Volunteers
- 114 people
- Sponsor
- CHU de Reims
Procedural Sedation
Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.
This randomized controlled trial will compare two medication combinations, ketamine-dexmedetomidine (Ketadex) and ketamine-propofol (Ketofol), for procedural sedation in adults undergoing painful procedures in the emergency…
- Trial name
- NCT07874919
- Testing
- Ketamine (1 mg/kg), propofol, Dexmedetomidine
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Sultan Qaboos University