Clinical trials: Ketorolac
Post Cataract Surgery
The TRIBECA Study (TRIessence/Byqlovi for Easier CAtaract Surgery)
A self-controlled, prospective clinical study of the safety, clinical efficacy, and patient acceptance of subconjunctival delivery of triamcinolone 40 mg/mL (Triesence) at the conclusion of cataract surgery or topical clobetasol…
- Trial name
- TRIBECA (NCT07276802)
- Testing
- Triamcinolone (Optional), control group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Research Insight LLC
Postoperative Pain
Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery
Ketorolac has been marketed for several years in other forms (tablet and injectable) for the short-term relief of pain. This study will test whether a new dosage form (nasal spray) containing ketorolac is effective at relieving…
- Trial name
- NCT00266786
- Testing
- Intranasal Ketorolac Tromethamine
- Where
- 6 sites in United States, New Zealand
- Volunteers
- 321 people
- Sponsor
- Egalet Ltd
Analgesic Drug Dependence, Colectomy
Opioid Free Anesthesia vs. Opioid Anesthesia Techniques.
A comparison of post-operative opioid use in Laparoscopic Colectomy patients receiving Opioid or Opioid-free Anesthesia.
- Trial name
- OFA vs OA (NCT03367988)
- Testing
- Opioid Anesthesia, Opioid-free Anesthesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Anesthesia, Gynecologic Cancer
ESP vs TAP in Total Laparoscopic Hysterectomy
The anesthetic techniques for videolaparoscopic surgery include general anesthesia, and locoregional anesthesia in association with general anesthesia in order to reduce or abolish post-operative pain with a simultaneous…
- Trial name
- ARTEMIDE (NCT04839445)
- Testing
- General anesthesia + TAP block, General anesthesia + ESP block
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- AUSL Romagna Rimini
Supratentorial Neoplasms
Opioid Free VS Opioid Anesthesia for Craniotomies
Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia…
- Trial name
- NCT04941040
- Testing
- Opioid free anesthetics, Opioid Anesthetics
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Kidney Stone
An Analgesia Protocol for Acute Renal Colic in the Emergency Department
An analgesia protocol for acute renal colic will lead to faster significant reductions in pain than prior practice.
- Trial name
- NCT00504283
- Testing
- Toradol, Morphine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer Female
Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn
Background: Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug that has been shown to reduce breakthrough narcotic consumption following orthopaedic, neurosurgical, and obstetrical procedures.
- Trial name
- KANGAROO (NCT03007381)
- Testing
- Ketorolac Tromethamine, Normal Saline
- Sponsor
- Nova Scotia Health Authority
Breast Cancer
SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery
This is a multicenter, first-in-human (FIH), open label, Phase 1 dose escalation and recommended Phase 2 dose (RP2D) extension trial with a primary objective to define the RP2D of SRG-514 when administered intraoperatively to…
- Trial name
- NCT06300411
- Testing
- SRG-514
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- SURGE Therapeutics
Pain, Postoperative
Ibuprofen Versus Ketorolac For Postoperative Pain Relief After Cesarean Section
The aim of this study will be to evaluate the effectiveness of intravenous ibuprofen versus intravenous ketorolac for postoperative pain relief after caesarian section 1.
- Trial name
- NCT05907993
- Testing
- Ibuprofen 800 mg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Kidney Cancer, Renal Cancer
NSAID Use After Robotic Partial Nephrectomy
The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.
- Conditions
- Kidney Cancer, Renal Cancer, Renal Neoplasm
- Trial name
- No-PAIN (NCT05842044)
- Testing
- Ketorolac, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Miami
Acute Pancreatitis
Epidural Anesthesia in Acute Pancreatitis
Acute pancreatitis is a common urgency with a mortality rate of up to 30% , decreased blood flow in the pancreatic microcirculation. It seems to be the main cause of the pathophysiology of acute pancreatitis.
- Trial name
- NCT02617199
- Testing
- Epidural anesthesia, intravenous analgesia
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer
Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)
Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer.
- Trial name
- KePreSt (NCT06150898)
- Testing
- Prospective data and sample collection, Ketorolac 10 Mg Oral Tablet, Pregabalin 75mg
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Jules Bordet Institute
Total Knee Arthroplasty
Optimizing Pain and Rehabilitation After Knee Arthroplasty
The aim of this study is to determine the best method of pain control that will help with rehabilitation after total knee arthroplasty (TKA).
- Trial name
- OPRA (NCT01616836)
- Testing
- continuous FNB, single femoral nerve block, local infiltration analgesia
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pain, Digital Block
Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain
This study aims to compare the analgesic effectiveness and side effects of intranasal ketorolac versus intranasal ketamine for reducing pain prior to digital nerve block procedures in patients with finger injuries in emergency…
- Trial name
- NCT07305883
- Testing
- Intranasal Ketorolac Tromethamine, Intranasal ketamine
- Volunteers
- 64 people
- Sponsor
- Tehran University of Medical Sciences
Analgesia
Analgesia After Total Knee Arthroplasty
The recovery from knee replacement surgery often involves a significant amount of pain. The best way to prevent/treat this pain is unknown.
- Trial name
- NCT00869037
- Testing
- Periarticular Injection, CFNB + Posterior Capsular Injection
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Manitoba
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Pain Reduction
Effect of Intracameral Phenylephrine/Ketorolac on Intraoperative Pain
To compare the effect of intraoperative intracameral Omidria (Phenylephrine and Ketorolac 1.0%/0.3%) verses 1% Lidocaine on pain reduction during and after cataract surgery.
- Trial name
- NCT04829799
- Testing
- 1% preservative-free lidocaine, Phenylephrine 1.0%/ Ketorolac 0.3%
- Sponsor
- University of Florida
Postoperative Nausea and Vomiting
Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery
Morbidly obese patients are at high risk for Postoperative Nausea and Vomiting (PONV) after surgery and general anesthesia. The results of our observational study indicate that 42.7% of patients require medication to treat PONV…
- Trial name
- NCT01449708
- Testing
- TIVA NoNarc
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Coastal Anesthesiology Consultants
Dry Eye Disease, Ocular Comfort
Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase
To compare bromfenac 0.09% and ketorolac 0.4% when used concomitantly with cyclosporine ophthalmic emulsion 0.05% in improving patient comfort during the induction phase of treatment for chronic dry eye disease
- Trial name
- NCT00520260
- Testing
- bromfenac, ketorolac
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Florida Eye Microsurgical Institute
Postoperative Pain Control in Surgical Neonates
The Use of Ketorolac in Surgical Neonates
The general purpose of this study is to characterize the safety profile of ketorolac in infants age 0-3 months. Our hypothesis is that ketorolac is safe in neonates, and effective in controlling pain with less narcotic…
- Trial name
- NCT01667120
- Testing
- Ketorolac
- Where
- United States
- Sponsor
- Nationwide Children's Hospital