Clinical trials: Liraglutide
Diabetes, Diabetes Mellitus, Type 2
Safety and Tolerability of Liraglutide in Japanese Subjects With Type 2 Diabetes
This trial is conducted in Japan. The aim of this trial is to assess the safety after multiple s.c. (subcutaneously) doses of liraglutide in Japanese subjects with type 2 diabetes.
- Trial name
- NCT01615978
- Testing
- liraglutide
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies
The aim of this study is to detail the (mechanisms underlying the) actions of the GLP-1 receptor agonists and DPP-4 inhibitors on the cardiovascular, renal and gastrointestinal systems in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT01744236
- Testing
- Liraglutide, Sitagliptin, Exenatide
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
Chronic kidney disease (CKD) is the progressive damage to kidney function, associated with an increased risk of cardiovascular diseases, such as stroke or myocardial infarct, particularly in the most severe stages of CKD, in…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
- Trial name
- ADIPO-CKD (NCT07309094)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Cardenal Herrera University
Diabetes, Diabetes Mellitus, Type 2
Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformin
This trial is conducted in Europe and North America. The aim of this trial is to compare the efficacy and safety of adding liraglutide versus addition of insulin aspart with the largest meal to insulin degludec in subjects with…
- Trial name
- BEGIN™ (NCT01388361)
- Testing
- insulin degludec, insulin aspart, liraglutide
- Where
- 124 sites in United States, Austria and 10 more
- Volunteers
- 413 people
- Sponsor
- Novo Nordisk A/S
Osteoarthritis, Obesity
Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- US-LOSEIT-I (NCT02931370)
- Testing
- Dietary Supplement: Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen
Diabetes
Replication of the LEADER Diabetes Trial in Healthcare Claims
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT03936049
- Testing
- Liraglutide, DPP-4 inhibitor
- Where
- United States
- Volunteers
- 168,690 people
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes
Incretin Effect on the Immunological Phenotype
Assessment of the effect of incretin based therapies (Liraglutide and Saxagliptin) on immune cells in healthy subjects and patients with type 1 diabetes
- Trial name
- NCT01782261
- Testing
- Liraglutide, Saxagliptin
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Metabolism and Nutrition Disorder, Obesity
A Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Liraglutide in Obese Children Aged 7 to 11 Years
This trial is conducted in the United States of America. The aim of this trial is to investigate safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect of the…
- Trial name
- NCT02696148
- Testing
- liraglutide
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Liraglutide Versus Placebo as add-on to Existing Diabetes Medication in Subjects With Type 2 Diabetes and Moderate Renal Impairment
This trial is conducted in Europe and the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of liraglutide in subjects with type 2 diabetes and moderate renal impairment.
- Trial name
- NCT01620489
- Testing
- liraglutide
- Where
- 97 sites in United States, France and 4 more
- Volunteers
- 279 people
- Sponsor
- Novo Nordisk A/S
Heart Failure With Preserved Ejection Fraction, Obesity
GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry
GLIDE-HF is a prospective, single-center, non-interventional observational cohort registry conducted within routine outpatient heart failure care at a cardiology clinic in Poland.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Diastolic Heart Failure, Pulmonary Hypertension
- Trial name
- GLIDE-HF (NCT07787936)
- Testing
- GLP-1 / GIP receptor agonist
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Obesity
Anti-obesity Pharmacotherapy and Inflammation
This study evaluates the relationship between weight loss, circulating inflammatory markers and lipids from 24 patients before and after 6 months of pharmacotherapy as a standard of care for anti-obesity treatment
- Trial name
- NCT05756764
- Testing
- Semaglutide, Phentermine-Topiramate combination, Phentermine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Diabetes Mellitus
IDegLira HIGH Trial
Basal-bolus insulin therapy is recommended for patients with poorly controlled type 2 diabetes (T2D) and HbA1c >9%. However, basal-bolus insulin is labor intensive and associated with increased risk of hypoglycemia, glycemic…
- Trial name
- NCT03737240
- Testing
- IDegLira, Insulin Degludec (U-100), Insulin Aspart
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Emory University
Diabetes, Diabetes Mellitus, Type 2
The Effect of Liraglutide on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
This trial is conducted in the United States of America (USA). The purpose of the trial is to assess the effect of liraglutide on forearm blood flow in subjects with type 2 diabetes who are on diet and lifestyle changes or…
- Trial name
- NCT00620282
- Testing
- liraglutide, glimepiride
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Research Study Looking at Blood Sugar Control in People With Type 2 Diabetes Previously Treated With Premix Insulin and Initiating Treatment With Insulin Degludec/Liraglutide (IDegLira) in Local Clinical Practice in Croatia
The purpose of this study is to look at the blood sugar control in participants with type 2 diabetes previously treated with premix insulins and initiating treatment with IDegLira.
- Trial name
- GLIDE (NCT05479591)
- Testing
- IDegLira
- Sponsor
- Novo Nordisk A/S
Acute ST-segment Elevation Myocardial Infarction
Effects of Glucagon Like Peptide-1 on No-reflow
The investigators planned to evaluate the effects of liraglutide on no-reflow in patients with acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT02507128
- Testing
- liraglutide
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Chen Wei Ren, MD
Osteoarthritis, Obesity
Liraglutide 3 mg for Knee Osteoarthritis
A randomised, double blind, placebo-controlled, parallel group, and single-centre trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis.
- Trial name
- LOSEIT (NCT02905864)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Type 2 Diabetes Mellitus
Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin Therapy
The purpose of this studay is to compare the efficacy of different hypoglycemic regimens versus twice-daily premixed insulin in type 2 diabetes mellitus (T2DM) patients after short-term ntensive Insulin Therapy by using…
- Trial name
- NCT05545800
- Testing
- metformin+empagliflozin+insulin glargine, IDegLira, premixed insulin analogues
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xiangya Hospital of Central South University
Obesity, Blood Pressure
Study of the Cardiometabolic Effects of Obesity Pharmacotherapy
The aim of the present study is to compare the efficacy of liraglutide vs. naltrexone/bupropion on metabolic and cardiovascular risk markers, weight loss, as well as the postprandial secretion of gastrointestinal hormones…
- Trial name
- NCT04575194
- Testing
- Liraglutide 6 MG/ML [Saxenda], Naltrexone-Bupropion Combination
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Healthy Human Male Subjects
The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors.
- Trial name
- NCT01695109
- Testing
- Liraglutide
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Type 1
Effect of Liraglutide on Subclinical Atherosclerosis in Patients With Type 1 Diabetes Mellitus
The aim of the trail is investigate the effect of liraglutide 1.8mg as add-on to insulin for 6 months on carotid intima media thickness and cardiovascular risk factors in subjects with type 1 diabetes mellitus.
- Trial name
- NCT05467514
- Testing
- Liraglutide
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- David Sanchez Garcia