Clinical trials: Liraglutide
Healthy
Effect of Repeated Administration of Liraglutide on Insulinogenic Indices
The study investigates the effect of glucagon-like peptide receptor 1 agonist, liraglutide, on insulin secretion. Study hypothesis: the effect of liraglutide on insulin release may change after repeated administration.
- Trial name
- NCT02089256
- Testing
- Liraglutide
- Where
- Estonia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Healthy
A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal.
- Trial name
- NCT04466566
- Testing
- Saline, Exendin-9,39, Liraglutide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Adrian Vella
Diabetes Mellitus, Type 1
Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)
Type 1 diabetes is an autoimmune disease characterized by destruction of pancreatic beta-cells, resulting in absolute deficiency of insulin. Presently there is no known cure.
- Trial name
- NCT03182426
- Testing
- Plerixafor, Alemtuzumab, Anakinra
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults
The main objectives of the trial are to study whether daily treatment with liraglutide improves insulin secretion and glucose metabolism, and whether liraglutide treatment is tolerable and safe in subjects with preclinical type 1…
- Trial name
- NCT02611232
- Testing
- Victoza®
- Where
- 3 sites in Finland
- Volunteers
- 42 people
- Sponsor
- University of Oulu
Atrial Fibrillation
Liraglutide Effect in Atrial Fibrillation
The goal (or purpose) of this study is to evaluate (study) a new way to stabilize (steady) the activity between the fat deposits surrounding the heart and the left atrium.
- Trial name
- LEAF (NCT03856632)
- Testing
- Liraglutide, RFM, Anti Arrhythmics
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Type 1 Diabetes
52 Week Trial of Liraglutide in Type 1 Diabetes
To our knowledge, no trial has specifically studied the effect of liraglutide combined with a basal/bolus insulin regimen in type 1 diabetes in a cross-over, double-blind, unicentric model.
- Trial name
- LIDO (NCT01787916)
- Testing
- Liraglutide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- CHU de Quebec-Universite Laval
Obesity
A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Non-diabetic Severely Obese Participants
The purpose of this study is to assess the effects of JNJ-64565111 compared with placebo after 26 weeks of treatment on the percent change in body weight from baseline and to assess the safety and tolerability, in non-diabetic…
- Trial name
- NCT03486392
- Testing
- JNJ-64565111 Dose Level 1, JNJ-64565111 Dose Level 2, JNJ-64565111 Dose Level 3
- Where
- 51 sites in United States, Belgium and 4 more
- Volunteers
- 474 people
- Sponsor
- Janssen Research & Development, LLC
Diabetes, Diabetes Mellitus, Type 2
Safety and Efficacy of Liraglutide in Combination With an OAD in Subjects With Type 2 Diabetes Insufficiently Controlled on OAD Alone
This trial was conducted in Japan. The aim of this trial was to evaluate the safety and efficacy of once daily administration of liraglutide in combination with an oral anti-diabetic drug (OAD) in Japanese subjects with type 2…
- Trial name
- NCT01512108
- Testing
- liraglutide, oral anti-diabetic drug
- Where
- 36 sites in Japan
- Volunteers
- 363 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to compare the benefits and risks associated with the use of 2 treatment strategies to lower blood sugar in participants aged 65 and older with T2DM.
- Trial name
- IMPERIUM (NCT02072096)
- Testing
- Glimepiride, Metformin, Pioglitazone
- Where
- 34 sites in United States, Austria and 3 more
- Volunteers
- 192 people
- Sponsor
- Eli Lilly and Company
Abdominal Wall Hernia
Preoperative Weight Loss for Open Abdominal Wall Reconstruction
The goal of this randomized controlled trial is to compare preoperative intensive weight management to upfront surgery in obese patients undergoing complex abdominal wall reconstruction.
- Trial name
- NCT05925959
- Testing
- Preoperative Weight Management Program
- Where
- 2 sites in United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Benjamin T. Miller
Type II Diabetes
Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging
Type II diabetes is a known risk factor for heart failure, particularly through the progressive development of diabetic cardiomyopathy.
- Trial name
- LICAS-MR (NCT03498001)
- Testing
- GLP-1 agonists, Cardiac MRI, Follow up by phone
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ischemic Cardiomyopathy
Clinical Study of Liraglutide in Improving Cardiac Function for Patients With Ischemic Cardiomyopathy
It has been known that liraglutide reduces infarct size, improved left ventricular function, reduce myocardial stunning, and play a protective role in myocardial ischemia-reperfusion injury for patients with acute myocardial…
- Trial name
- NCT02930265
- Testing
- Liraglutide
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation
This trial is conducted in Europe and North America. The aim of this trial is to investigate if liraglutide treatment can increase the proportion of insulin-independent subjects one year after islet cell transplantation who…
- Trial name
- NCT01206101
- Testing
- liraglutide
- Where
- 16 sites in United States, Canada and 4 more
- Volunteers
- 3 people
- Sponsor
- Novo Nordisk A/S
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes, Diabetes Mellitus, Type 1
The Effect of Liraglutide Adjunct to Insulin on Glucagon Response to Hypoglycaemia in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate if liraglutide adjunct to insulin treatment changes the glucagon response during hypoglycaemia in subjects with type 1 diabetes compared with conventional…
- Trial name
- NCT01536665
- Testing
- liraglutide
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Novo Nordisk A/S
Obesity
The Effect and the Pharmacogenomics Study of Liraglutide in Obese Patients
This studay evaluates the effect of liraglutide in the treatment of obese patients ande the influence of genetic factors on the curative effect.Half of participants will receive Liraglutide alone,while the other half who can not…
- Trial name
- NCT04839237
- Testing
- Liraglutide, Liraglutide;metformin
- Where
- China
- Sponsor
- Xiangya Hospital of Central South University
Type 2 Diabetes Mellitus
Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients
Specific Aim 1.To examine whether the combination of liraglutide plus canagliflozin can prevent the increase in Hepatic Glucose Production (HGP) following institution of canagliflozin therapy and produce an additive or even…
- Trial name
- NCT02324842
- Testing
- Canagliflozin, Liraglutide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes, Diabetes Mellitus, Type 2
A Retrospective Database Assessment of Clinical Effectiveness in Type 2 Diabetes Patients Treated With Liraglutide From Primary Care Centers in Sweden
This trial is conducted in Europe. The aim of this study is to investigate a retrospective database assessment of clinical effectiveness in type 2 diabetes patients treated with liraglutide from primary care centers in Sweden.
- Trial name
- NCT02077946
- Testing
- liraglutide, sitagliptin
- Where
- Sweden
- Volunteers
- 1,059 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Treated With Insulin, Obesity
Dulaglutide Versus Liraglutide in Obese Type 2 Diabetic Adolescents Using Metformin
To compare the efficacy and effect on glycemic control of Dulaglutide versus Liraglutide in obese Type 2 diabetic adolescents using metformin
- Conditions
- Type 2 Diabetes Treated With Insulin, Obesity, Adolescent Obesity
- Trial name
- NCT04829903
- Testing
- Dulaglutide, Liraglutide
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Corporacion Parc Tauli
Diabetes Mellitus, Type 2
A Study to Determine the Efficacy and Safety of Albiglutide as Compared With Liraglutide.
This open-label study examines the efficacy and safety of albiglutide as compared with liraglutide in subjects with type 2 diabetes.
- Trial name
- NCT01128894
- Testing
- albiglutide, liraglutide
- Where
- 173 sites in United States, Australia and 6 more
- Volunteers
- 841 people
- Sponsor
- GlaxoSmithKline