Clinical trials: Losartan
Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease
Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)
The purpose of this study is to evaluate the efficacy of rosiglitazone alone compared with rosiglitazone plus metformin or rosiglitazone plus losartan in the treatment of biopsy proven nonalcoholic steatohepatitis (NASH).
- Trial name
- NCT00699036
- Testing
- avandia, metformin, losartan
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Brooke Army Medical Center
Hypertension, HIV
Integrating Hypertension Management in DSD for HIV
The goal of this implementation science study is to design evidence based and stakeholder informed implementation strategies to integrate the management of hypertension (HTN) into existing community anti-retro-viral treatment…
- Trial name
- HTN-DSD (NCT06366386)
- Testing
- Screening and treatment of hypertension among PLHIV in DSD models for HIV
- Where
- Uganda
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Type 2 Diabetes Mellitus, Hypertension
HYZAAR vs. Ramipril for Diabetes (0954A-245)(COMPLETED)
A study to test the safety and efficacy of HYZAAR as compared to Ramipril in patients with type 2 diabetes mellitus (high blood sugar) and hypertension (high blood pressure).
- Trial name
- NCT00480805
- Testing
- MK0954A, losartan potassium (+) hydrochlorothiazide (HYZAAR) / Duration of Treatment : 8 Weeks, Comparator : ramipril /Duration of Treatment : 8 Weeks
- Volunteers
- 312 people
- Sponsor
- Organon and Co
Renal Insufficiency, Chronic
Exploring the Impact of Nephropathy Formula No. 1 on Chronic Kidney Disease Patients
This study is a prospective randomized controlled trial, enrolling 70 patients with CKD stages 2-4, randomly divided into a control group and a treatment group, with 35 cases in each group.
- Trial name
- NCT06796660
- Testing
- Nephropathy Formula No. 1, integrated basic treatment for chronic kidney disease
- Where
- 3 sites in China
- Volunteers
- 70 people
- Sponsor
- Liu Zhanghong
Essential Hypertension
Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients
Hypertensive patients with moderate hypertension have a risk to develop cardiovascular events of 15-20% over a period of 10 years.
- Trial name
- NCT00716950
- Testing
- valsartan/amlodpine, losartan/amlodpine
- Where
- Italy
- Volunteers
- 187 people
- Sponsor
- University of Pavia
Hypertension
A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM)
The primary aim of the trial is to compare the influence of MICARDIS® (telmisartan 40-80 mg) and COZAAR® (losartan 50-100 mg) in lowering ambulatory diastolic blood pressure (DBP) during the last 6 hours of the 24-hour dosing…
- Trial name
- NCT02200640
- Testing
- High dose of Micardis®, once daily, Low dose of Micardis®, once daily, Low dose of COZAAR®, once daily
- Volunteers
- 333 people
- Sponsor
- Boehringer Ingelheim
Chronic Renal Failure, Hemodialysis
Effects of Shenkang Decoction on Creatinine and Blood Urea Nitrogen in Chronic Renal Failure Hemodialysis Patients
To explore the clinical effect of Shenkang Decoction in chronic renal failure (CRF) patients with hemodialysis (HD).
- Trial name
- NCT05631782
- Testing
- Shenkang decoction
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First People's Hospital of Zunyi
Marfan Syndrome
Randomized, Double-blind Study for the Evaluation of the Effect of Losartan Versus Placebo on Aortic Root Dilatation in Patients With Marfan Syndrome Under Treatment With Beta-blockers
To study the effect of losartan (an angiotensin receptor blocker-ARB) on aortic root growth in patients with Marfan syndrome, already treated with beta-blockers (BB). The effect of losartan will be compared to placebo.
- Trial name
- NCT00782327
- Testing
- Losartan
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Ghent
Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma
Losartan and Hypofractionated Rx After Chemo for Tx of Borderline Resectable or Locally Advanced Pancreatic Cancer
This phase I trial studies the side effects of losartan and hypofractionated radiation therapy after chemotherapy in treating patients with pancreatic cancer that may or may not be removed by surgery (borderline resectable) or…
- Conditions
- Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma, Locally Advanced Unresectable Pancreatic Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8
- Trial name
- SHAPER (NCT04106856)
- Testing
- Hypofractionated Radiation Therapy, Losartan, Losartan Potassium
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Hypertension
Comparison of Blood Pressure Lowering Effect Between Fimasartan and Losartan
Comparison of blood pressure lowering effect between Fimasartan and Losartan in the hypertensive patient during night and early morning time
- Trial name
- NCT02958631
- Testing
- Fimasartan, Losartan
- Volunteers
- 40 people
- Sponsor
- Chuncheon Sacred Heart Hospital
COPD, Emphysema
Efficacy of Losartan in Preventing Progression of COPD
Evidence in animals shows that losartan can prevent or reverse inflammation and lung damage due to smoking. The goal of this study is to determine whether this drug which is also used to treat hypertension can stabilize or…
- Conditions
- COPD, Emphysema, Chronic Bronchitis, Smoking
- Trial name
- NCT00720226
- Testing
- Losartan
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Johns Hopkins University
Healthy
Losartan Effects on Emotion-memory Interaction
The purpose of this study is to investigate whether a single dose of losartan (50 mg) can affect emotion-memory interaction in healthy humans and its underlying neural mechanisms.
- Trial name
- NCT04606225
- Testing
- Losartan
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
NAFLD - Nonalcoholic Fatty Liver Disease
Losartan for the Treatment of Pediatric NAFLD
A multicenter, randomized, double masked, placebo-controlled, parallel treatment groups phase 2 trial of losartan for pediatric nonalcoholic fatty liver disease (NAFLD).
- Trial name
- STOP-NAFLD (NCT03467217)
- Testing
- Losartan potassium
- Where
- 10 sites in United States
- Volunteers
- 83 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy
The Effects of Losartan on Reward Reinforcement Learning
This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.
- Trial name
- NCT04604938
- Testing
- Losartan
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Coronary Artery Disease, Hypertension
Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound
The purpose of this study is to evaluate the effect of intensive blood pressure control compared to standard blood pressure control on progression of coronary atherosclerosis by intravascular ultrasound in hypertensive patients…
- Trial name
- PREVUS (NCT01230216)
- Testing
- control systolic blood pressure less than 120 mmHg, control systolic blood pressure less than 140 mmHg
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Takeshi Morimoto
Hypertension
Bioequivalency Study of Losartan Potassium/Hydrochlorothiazide 100 mg /25 mg Tablet Under Fed Conditions
The objective of this study was to prove the bioequivalence of losartan potassium/hydrochlorothiazide 100/25 mg tablet under fed conditions.
- Trial name
- NCT01102465
- Testing
- losartan potassium hydrochlorothiazide
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Advanced Solid Tumors, Metastatic Melanoma
Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
This is an open-label, 3-arm, fixed-sequence study to evaluate the effect of single and multiple oral doses of encorafenib in combination with binimetinib on the single oral dose pharmacokinetics (PK) of cytochrome P450 (CYP)…
- Trial name
- NCT03864042
- Testing
- losartan, dextromethorphan, caffeine
- Where
- 29 sites in United States, Belgium and 3 more
- Volunteers
- 56 people
- Sponsor
- Pfizer
Hypertension,Essential, Hyperuricemia
Non-Inferiority Study of Aliskiren vs Losartan in the Treatment of Hypertension With Hyperuricemia
This clinical trial aims to evaluate the non-inferiority of Aliskiren compared to Losartan in the treatment of hypertension combined with hyperuricemia.
- Trial name
- NCT06718062
- Testing
- Aliskiren, Losartan
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Hansung University
Hyperoxaluria
Renal Protective Effect of ACEI and ARB in Primary Hyperoxaluria
This study will test the effectiveness of two medications: ACEI (angiotensin converting enzyme inhibitor)and ARB (angiotensin receptor blocker) in reducing the renal injury induced by hyperoxaluria in patients with Primary…
- Trial name
- NCT00280215
- Testing
- ACEI / Angiotensin converting enzyme inhibitor, ARB /Angiotensin Receptor Blocker
- Sponsor
- Mayo Clinic
Hypertension
Efficacy/Safety of Amlodipine Plus Losartan Versus Losartan in Patients With Essential Hypertension
The purpose of this study is to evaluate of efficacy and safety of amlodipine plus losartan and losartan alone in patients with essential hypertension inadequately controlled on losartan monotherapy.
- Trial name
- NCT00940680
- Testing
- Amlodipine plus Losartan, Losartan
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Hanmi Pharmaceutical Company Limited