Clinical trials: Losartan
Hypertension
Efficacy and Safety of Nebivolol (Added to Lisinopril or Losartan) in Hypertensive Patients
This study will assess blood pressure reduction with nebivolol or placebo in patients taking lisinopril or losartan.
- Trial name
- NCT00734630
- Testing
- nebivolol
- Where
- 75 sites in United States
- Volunteers
- 491 people
- Sponsor
- Forest Laboratories
Hypertension
A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® / LORZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM)
The primary aim of the trial is to compare the influence of MICARDIS® (telmisartan) and COZAAR® / LORZAAR® (losartan) in lowering ambulatory diastolic blood pressure (DBP) during the last 6 hours of the 24-hour dosing interval as…
- Trial name
- TOPAS (NCT02200653)
- Testing
- High dose of MICARDIS®, once daily, Low dose of MICARDIS®, once daily, Low dose of COZAAR® / LORZAAR®, once daily
- Volunteers
- 387 people
- Sponsor
- Boehringer Ingelheim
Heart Failure
Effects of Losartan on Insulin Resistance in Patients With Heart Failure
The purpose of this study is to evaluate the effects of losartan, an ARB, on glucose metabolism and inflammatory cytokines in CHF patients treated with ACE inhibitors.
- Trial name
- NCT00663377
- Testing
- losartan
- Volunteers
- 16 people
- Sponsor
- Tottori University Hospital
Hypertension, High Blood Pressure
N-of-1 Trials for Blood Pressure Medications in Adults
Many patients want to know which blood pressure medication is the best for them. In this study, we will test the feasibility of a new approach to determining the best blood pressure medication for individual patients by…
- Trial name
- NCT02744456
- Testing
- Losartan, Amlodipine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Healthy Volunteers
The Effect of Losartan on Emotional Processing in Healthy Volunteers
This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.
- Trial name
- NCT03434054
- Testing
- Losartan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Renal Transplant Failure, Cardiovascular Complication
Cardiorenal Effecs of Losartan in Kidney Transplant Recipients
The influence of Losartan to cardiovascular and renal outcomes in patients after renal transplatation.
- Trial name
- CELART (NCT05243446)
- Testing
- Losartan
- Where
- Poland
- Volunteers
- 740 people
- Sponsor
- Medical University of Gdansk
Hypertension
Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)
A study to evaluate the effects of combination losartan versus combination atenolol in patients with ambulatory systolic hypertension.
- Trial name
- NCT00140959
- Testing
- MK0954, losartan potassium/Duration of Treatment: 18 weeks, Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypertension
Hyzaar Asia HEAALTH (0954A-950)
The objective of the study is to estimate the percentage of patients who reach blood pressure goal after 8 weeks of treatment with losartan/HCTZ combination.
- Trial name
- NCT00354991
- Testing
- losartan potassium (+) hydrochlorothiazide
- Volunteers
- 437 people
- Sponsor
- Merck Sharp & Dohme LLC
Coarctation of Aorta, High Blood Pressure
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
- Trial name
- VALUE (NCT06150560)
- Testing
- Losartan, Amlodipine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Olmesartan Medoxomil and Diabetic Nephropathy
Evaluation of several olmesartan dosages compared to losartan on proteinuria, renal function and inflammatory markers in patients with diabetic nephropathy
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Nephropathy, Proteinuria, Renal Disease
- Trial name
- NCT00362960
- Testing
- Olmesartan medoxomil, Losartan
- Where
- 27 sites in Czechia, Estonia and 5 more
- Volunteers
- 300 people
- Sponsor
- Sankyo Pharma Gmbh
Hypertension
Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The researchers hypothesize that: 1.
- Trial name
- Renin (NCT00684489)
- Testing
- clinical hypertension specialist-no specific med. Any anti-hypertension meds., renin guided therapeutics-no specific med. Any anti-hypertensive med.
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
NSCLC (Non-small Cell Lung Cancer), Thyroid Cancer
Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors
An open-label drug-drug interaction study to evaluate the effects of pralsetinib (Gavreto) on the pharmacokinetics of a CYP450 probe substrate cocktail and, in female participants, a hormonal probe substrate, in participants with…
- Conditions
- NSCLC (Non-small Cell Lung Cancer), Thyroid Cancer, Solid Tumor Malignancies, Advanced Malignancies
- Trial name
- NCT07704658
- Testing
- Pralsetinib, CYP3A4, CYP2C8, and CYP2C9 substrates, and hormonal contraceptive
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Rigel Pharmaceuticals
Hypertension
A Study to Evaluate Whether Losartan Protects the Kidney in Hypertensive Diabetic Participants With Microalbuminuria (MK0954-365 AM1)
This study will evaluate whether losartan protects the kidney in hypertensive Type II diabetic participants with microalbuminuria.
- Trial name
- NCT01390415
- Volunteers
- 136 people
- Sponsor
- Organon and Co
Locally Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma
Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma
This phase Ib trial tests the safety, side effects and how well losartan, pembrolizumab and stereotactic body radiation therapy (SBRT) for the treatment of patients with head and neck squamous cell carcinoma that has come back to…
- Conditions
- Locally Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma, Refractory Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT06211335
- Testing
- Losartan, Pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of California, Davis
Blood Pressure
Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment
The purpose of this study is to evaluate the importance of providing guidelines to patients via active telephone calls in blood pressure control and in the discontinuation of treatment among hypertensive patients.
- Trial name
- NCT00813722
- Testing
- phone call, amlodipine (calcium chanel blocker) and losartan (at1 antagonist), atenolol (beta blocker) and hydrochlorothiazide (diuretic)
- Where
- 2 sites in Brazil
- Volunteers
- 400 people
- Sponsor
- University of Sao Paulo
Sacubitril/Valsartan, Hypertension
Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study
The purpose of this study is to investigate the effect of sacubitril/valsartan on cardiac function assessed by cardiac magnetic resonance (CMR) in hypertensive patients stratified by BMI.
- Conditions
- Sacubitril/Valsartan, Hypertension, Obesity
- Trial name
- NCT05498675
- Testing
- Sacubitril / Valsartan Oral Tablet [Entresto], ACEI/ARB
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Friendship Hospital
Marfan Syndrome
Atenolol Versus Losartan in the Prevention of Progressive Dilation of the Aorta in Marfan Syndrome
The purpose of this study is to evaluate the efficacy of Losartan versus Atenolol in the progression of aortic dilatation in patients with Marfan syndrome.
- Trial name
- LO-AT-MARFAN01 (NCT01145612)
- Testing
- Losartan, Atenolol
- Where
- 2 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Forteza, Albert, M.D.
Healthy
The Effects of Losartan on Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on salience processing
- Trial name
- NCT04606212
- Testing
- Losartan
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Cognitively Normal Older Adults, Hypertension
Risk Reduction for Alzheimer's Disease
Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Alzheimer's Disease
- Trial name
- rrAD (NCT02913664)
- Testing
- Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine), Aerobic Exercise Training, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 513 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension
Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial
The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.
- Trial name
- COMFORT (NCT00670787)
- Testing
- Combination pill of losartan and hydrochlorothiazide
- Where
- Japan
- Volunteers
- 207 people
- Sponsor
- Kyushu University