Clinical trials: Losartan
Healthy Normotensive Participants
Pharmacokinetic Interactions of Losartan and Hydrochlorothiazide
This study was conducted to investigate any potential reaction between losartan and hydrochlorothiazide.
- Trial name
- PKLH (NCT01858623)
- Testing
- Losartan/hydrochlorothiazide, Losartan, Hydrochlorothiazide
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Fasting
Bioequivalence Study of Amlodipine / Losartan/ Hydrochlorothiazide of PHARMALINE, Lebanon Under Fastion Conditions
To assess the bioequivalence of the investigational TEST product with the marketed REFERENCE products by measurement of Plasma concentrations of Amlodipine ,Losartan, Carboxylic acid losartan metabolite \& Hydrochlorothiazide in…
- Trial name
- NCT01713647
- Testing
- Amlodipin, losartan, HCTZ
- Where
- Jordan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Research Unit, Jordan
Hypertrophic Cardiomyopathy
Inhibition of the Renin Angiotensin System With Losartan in Patients With Hypertrophic Cardiomyopathy
Objective The objective of the study is to assess the structural and functional cardiac effects of treatment with losartan in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- INHERIT (NCT01447654)
- Testing
- Losartan
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Henning Bundgaard
Diabetic Nephropathies
Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy
This study was designed to assess the efficacy of adding pentoxifylline to losartan in comparison with increasing dose of losartan in type 2 diabetes patients with nephropathy.
- Trial name
- NCT03006952
- Testing
- Pentoxifylline, Losartan
- Where
- Iran
- Volunteers
- 59 people
- Sponsor
- Tehran University of Medical Sciences
Renal Disorder
Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases (0954-213)
Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.
- Trial name
- NCT00140985
- Testing
- MK0954, losartan potassium/Duration of Treatment: 20 weeks, Comparator: amlodipine / Duration of Treatment: 20 weeks
- Volunteers
- 97 people
- Sponsor
- Organon and Co
Essential Hypertension
Olmesartan Medoxomil Versus Losartan in Patients With Hypertension
The purpose of this study is to determine the efficacy and safety of oral administration of olmesartan medoxomil compared to losartan in subjects with mild to moderate hypertension.
- Trial name
- NCT00857285
- Testing
- olmesartan medoxomil, losartan potassium
- Where
- 3 sites in Taiwan
- Volunteers
- 130 people
- Sponsor
- Daiichi Sankyo
Hypertension
Community-based HEARTS Intervention (Pilot)
The goal of this pilot study is to assess the feasibility of health system change intervention with a focus on recruitment of patients with hypertension, initiation of antihypertensive medication, and retention of patients in…
- Trial name
- CB-HEARTS (NCT05954884)
- Testing
- Telemedicine-based WHO HEARTS package
- Volunteers
- 400 people
- Sponsor
- National Heart Foundation of Bangladesh
PRP, Losartan
The Effect of Combined Use of Anti-fibrotic Agent With Platelet Rich Plasma on Skeletal Muscle Healing After Acute Injuries
The aim of this comparative study is to determine whether or not LOSARTAN with its anti-fibrotic action has an added effect when administrated with platelet rich plasma injection on skeletal muscle healing and on decreasing the…
- Conditions
- PRP, Losartan, Muscle Injury, Sport Injury
- Trial name
- NCT05827484
- Testing
- Autologous platelets rich plasma, Autologous platelets rich plasma + oral LOSARTAN administration
- Volunteers
- 20 people
- Sponsor
- Mostafa Hassanein, Msc
Proteinuria, Diabetes (DM)
Proteinuria in Normotensive Diabetic Patients: ARBs Alone or in Combination of SGLT2i
Proteinuria is an early marker of diabetic kidney disease and predicts progression to chronic kidney disease and cardiovascular complications.
- Trial name
- NCT07586371
- Testing
- ARBs alone, ARBs in combination of SGLT2i
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dr Mudassar Saeed Pansota
Hypertension
Morning Hypertension and Preminent Therapy Study
It is difficult to control morning hypertension in practical clinical situation. Angiotensin receptor blocker (ARB) and thiazide are suggested to be effective to maintain the antihypertensive effects for 24 hours.
- Trial name
- NCT00795847
- Testing
- Preminent (losartan/hydrochlorothiazide combination drug)
- Where
- Japan
- Volunteers
- 216 people
- Sponsor
- Kurume University
Hypertension
Bioequivalency Study of Losartan Potassium 100 mg Tablet Under Fed Conditions
The objective of this study was to prove the bioequivalence of Losartan Potassium 100 tablet under fasted conditions.
- Trial name
- NCT01216878
- Testing
- losartan potassium
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Knee Arthroplasty, Total
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.
- Trial name
- NCT06108063
- Testing
- Losartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Steadman Philippon Research Institute
Diabetes, Kidney Disease
Improving Outcomes in Patients With Kidney Disease Due to Diabetes
Kidney disease affects about one out of three people with diabetes mellitus, a common medical problem. Treatment of kidney disease with medications that lower blood pressure can slow the kidney disease but there is no known cure.
- Conditions
- Diabetes, Kidney Disease, Hypertension
- Trial name
- NCT00381134
- Testing
- losartan 100 mg orally once daily, spironolactone 25 mg orally once daily
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Inflammation, Fibrosis
Losartan to Reduce Inflammation and Fibrosis Endpoints in HIV Trial
The purpose of this study is to evaluate the potential effectiveness of losartan (100mg daily) for reducing inflammation and improving immune recovery.
- Trial name
- LIFE-HIV (NCT02049307)
- Testing
- Losartan 100mg daily
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- Hennepin Healthcare Research Institute
Hypertension
Telmisartan Compared to Losartan + Hydrochlorothiazide in Patients With Mild-to-moderate Essential Hypertension
The general aim and clinical objective of this trial is to determine the effect of telmisartan 80 mg compared to losartan 50 mg + HCTZ (Hydrochlorothiazide) 12.5 mg on reduction of blood pressure (BP) in patients with mild to…
- Trial name
- NCT02183701
- Testing
- Telmisartan, Losartan + Hydrochlorothiazide
- Volunteers
- 715 people
- Sponsor
- Boehringer Ingelheim
Emotional Processing
Losartan and Emotional Processing in Young People
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.
- Trial name
- NCT06636812
- Testing
- Losartan potassium
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cerebral Small Vessel Diseases
Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
Multicentre, multinational, prospective randomised, open-label, 3 sequence crossover phase III b clinical trial with blinded endpoint assessment (PROBE-design) in 75 patients with sporadic small vessel diseases (SVDs) and in 30…
- Trial name
- TREAT-SVDs (NCT03082014)
- Testing
- Amlodipine, Losartan, Atenolol
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 101 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Hypertension
A Study To Evaluate The Efficacy Of Eplerenone Compared With Losartan For The Treatment Of Patients With Mild To Moderate Hypertension
The purpose this study is to compare the efficacy of eplereonone and losartan in patients with mild to moderate hypertension.
- Trial name
- NCT00649311
- Testing
- eplerenone, Losartan
- Where
- 2 sites in Taiwan
- Volunteers
- 248 people
- Sponsor
- Pfizer
Hypertension
PROBE Parallel 6-week Treatment Comparing Telmisartan/Hydrochlorothiazide (HCT) (40/12.5 or 80/12.5) With Losartan/HCT (50/12.5) Using Ambulatory Blood Pressure Monitoring (ABPM)
To demonstrate that Telmisartan combined with Hydrochlorothiazide (MICARDIS® HCT) is superior to Losartan with Hydrochlorothiazide (Hyzaar®) in lowering blood pressure in mild-moderate hypertensives.
- Trial name
- NCT00274638
- Testing
- Telmisartan & Hydrochlorothiazide, Losartan & Hydrochlorothiazide, ABPM
- Where
- 69 sites in United States
- Volunteers
- 805 people
- Sponsor
- Boehringer Ingelheim
Diabetic Nephropathy
Renoprotection in Early Diabetic Nephropathy in Pima Indians
This investigation is a randomized, double-blinded, placebo-controlled clinical trial in adult diabetic Pima Indians with normal urinary albumin excretion (albumin-to-creatinine ration less than 30 mg/g) or microalbuminuria…
- Trial name
- NCT00340678
- Testing
- Losartan
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)