Clinical trials: Losartan
Heart Failure
The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
Heart failure (HF) is a chronic condition that is characterized by a weakened and enlarged heart. It typically causes symptoms such as breathlessness and swelling of the legs, and it is a serious illness that shortens life…
- Trial name
- TAPERED-HF (NCT07513883)
- Testing
- Down-titration, Continuation of guideline-directed heart failure therapy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg
Healthy
Drug-Drug Interaction Study With PF-05089771
This study will test the potential for PF-05089771 to interact with a cocktail of drugs
- Trial name
- NCT01934569
- Testing
- Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771
- Where
- Belgium
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Aortic Valve Insufficiency
Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB
The purpose of this study is to assess the efficacy of sacubitril-valsartan compared to the combination of ARB/CCB on left ventricular remodeling in patients with chronic aortic valve regurgitation.
- Trial name
- REVERSE-AR (NCT05212597)
- Testing
- Sacubitril-valsartan, Amlodipine-losartan
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Hypertension
Fixed-Free HTN Trial
Evaluation of the effect of FIXED triple anti-hypertensive therapy with losartan-amlodipin-HCTZ vs any free triple combination therapy chosen by the treating physician for patients with uncontrolled hypertension
- Trial name
- NCT03578042
- Testing
- Losartan and amlodipine and hydrochlorothiazide, Standard of care
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Hotel Dieu de France Hospital
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Hypertension, Dyslipidemias
A Phase 3 Study to Compare the Efficacy and Safety of Co-administered HGP0608, HGP0904 and HCP1306 Versus HCP1701 in Patients With Hypertension and Dyslipidemia
A Randomized, Double-blinded, Multi-center, Phase III Study to Compare The Efficacy and Safety of Co-administered HGP0608, HGP0904 and HCP1306 versus HCP1701 in Patients with Hypertension and Dyslipidemia
- Trial name
- NCT04074551
- Testing
- HCP1701, Losartan, Amlodipine
- Where
- South Korea
- Volunteers
- 145 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Chronic Kidney Insufficiency, Angiotensin-Converting Enzyme Inhibitors
Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
The purpose of this study is to determine whether fosinopril and losartan are effective in the treatment of patients with Chronic Kidney Disease(CKD) stage 3.
- Conditions
- Chronic Kidney Insufficiency, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Type 1 Receptor Blockers, Proteinuria
- Trial name
- FLIP (NCT00565396)
- Testing
- Fosinopril and Losartan
- Where
- 26 sites in China
- Volunteers
- 400 people
- Sponsor
- Shanghai Municipal Health Bureau
Hypertension
Bioequivalency Study of Losartan Potassium/Hydrochlorothiazide 100 mg /25 mg Tablet Under Fed Conditions
The objective of this study was to prove the bioequivalence of losartan potassium/hydrochlorothiazide 100/25 mg tablet under fed conditions.
- Trial name
- NCT01102465
- Testing
- losartan potassium hydrochlorothiazide
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Diabetic Nephropathy
Adiponectin and Insulin Resistance in Diabetic Nephropathy
Plasma adiponectin concentration is inversely associated with renal function. There is little literature on adiponectin levels and regulation by antihypertensive medication with an angiotensin II-receptor blocker (ARB)…
- Trial name
- NCT00774904
- Testing
- Losartan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xi'an Jiaotong University
Healthy
A Randomized, Open-label, Single Dose, Two-way Crossover Clinical Trial to Compare the Safety, Pharmacokinetic Profiles of UI15AML055MT and Amosartan® Tablet 5/50 mg After a Single Oral Administration in Healthy Male Volunteers
A randomized, open-label, single dose, two-way crossover clinical trial to compare the safety, pharmacokinetic profiles of UI15AML055MT and Amosartan® tablet 5/50 mg after a single oral administration in healthy male volunteers
- Trial name
- UI15AML055MT (NCT02166398)
- Testing
- UI15AML055MT, Amosartan 5/50
- Where
- South Korea
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Hypertension, Metabolic Disorder
A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)
To determine if a one year treatment Losartan with or without HCTZ at different dosages have an effect on metabolic parameters in patients with hypertension and the metabolic syndrome.
- Trial name
- NCT00546052
- Testing
- losartan potassium (+) hydrochlorothiazide
- Volunteers
- 1,738 people
- Sponsor
- Organon and Co
Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into circulation.
- Conditions
- Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy, Myocardial Ischemia
- Trial name
- NCT00001534
- Testing
- Losartan
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Renal Transplant Failure, Cardiovascular Complication
Cardiorenal Effecs of Losartan in Kidney Transplant Recipients
The influence of Losartan to cardiovascular and renal outcomes in patients after renal transplatation.
- Trial name
- CELART (NCT05243446)
- Testing
- Losartan
- Where
- Poland
- Volunteers
- 740 people
- Sponsor
- Medical University of Gdansk
Hypertension
Hypertension in Young Adults Trial
This is a pilot randomized controlled trial which will test the effect of 3 different anti-hypertensive agents and 3 different strategies of engaging young adults in home blood pressure monitoring on blood pressure control, with…
- Trial name
- NCT05370599
- Testing
- Anti-hypertensive agent: amlodipine, Anti-hypertensive agent: Chlorthalidone, Anti-hypertensive agent: Losartan
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension
The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)
This study will evaluate the effect of Aliskiren and Losartan on renal blood flow using PAH clearance, PC MRA and ASL MRI methodologies.
- Trial name
- NCT00856960
- Testing
- Aliskiren, Comparator: Losartan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension
Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While Under Losartan Treatment
Losartan is an antihypertensive drug belonging to the ARB family. It is characterized as the substrate of the Multi Drug Resistance-1 (MDR1) drug-efflux protein (a pump that ensures the removal of drugs/foreign substances out of…
- Trial name
- NCT05349825
- Testing
- Genetic analysis and Losartan plazma level measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Pamukkale University
Hypertension
Efficacy/Safety of Amlodipine Plus Losartan Versus Losartan in Patients With Essential Hypertension
The purpose of this study is to evaluate of efficacy and safety of amlodipine plus losartan and losartan alone in patients with essential hypertension inadequately controlled on losartan monotherapy.
- Trial name
- NCT00940680
- Testing
- Amlodipine plus Losartan, Losartan
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension
Effectiveness and Safety of Sequential Triple Combination Therapy (Amlodipine/Losartan/Chlorthalidone) in Korean Patients With Hypertension
A multicenter, prospective, non-interventional, observational study to evaluate effectiveness and safety of sequential triple combination therapy (amlodipine/losartan/chlorthalidone) in Korean patients with hypertension
- Trial name
- AMPR-OS-2503 (NCT07784296)
- Testing
- AMOPREL TAB 1.67/16.67/4.17mg
- Where
- South Korea
- Volunteers
- 3,500 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Chronic Renal Disease
Residual Renal Function Preservation in Peritoneal Dialysis Patients
Aldosterone blockade is useful in preserving residual renal function in patients on PD.The long term efficacy of dual blockade of the RAAS is better than monotherapy.
- Trial name
- NCT02190318
- Testing
- Losartan, spirolactone, blank control
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Xiangya Hospital of Central South University
Stress Disorders, Post-Traumatic
Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life.
- Trial name
- ANG-P (NCT02560805)
- Testing
- Microneurography, Combat virtual reality video clip, Handgrip Exercise
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Emory University