Clinical trials: Melatonin, completed
Jet Lag
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
This study will examine the effects of cortisol (hydrocortisone), melatonin, a combination of cortisol and melatonin, and placebo (an inactive substance) on jet lag symptoms.
- Trial name
- NCT00097474
- Testing
- Hydrocortisone, Melatonin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Primary Insomnia
Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients
This is a randomised, placebo controlled study to evaluate the efficacy of a 3 week treatment period with Circadin® 2 mg in shortening sleep latency in patients with primary insomnia aged 18-80 with melatonin deficiency.
- Trial name
- NCT00397189
- Testing
- Circadin
- Where
- United Kingdom
- Volunteers
- 930 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep Disturbances
Individually Tailored Lighting System to Improve Sleep in Older Adults
In conjunction with investigators at the Cecil G. Sheps Center for Health Services Research, University of North Carolina (UNC) at Chapel Hill, we propose to develop and evaluate a low-cost, minimally obtrusive device that…
- Trial name
- NCT01855126
- Testing
- Blue light, Red light
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rensselaer Polytechnic Institute
Sleep, Sleep Disturbance
An Exploratory Investigation of a Supplement to Enhance Sleep Quality and Quantity
This double-blind study will examine the effectiveness of Dream Powder and Dream Powder Extra Strength over a six week period. The main outcomes of interest will be sleep quantity and quality, as well as self-reported changes in…
- Conditions
- Sleep, Sleep Disturbance, Sleep Hygiene
- Trial name
- NCT05521243
- Testing
- Beam Organics Dream Powder, Beam Organics Dream Powder Extra Strength
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beam
Phenylketonuria (PKU)
Effects of Kuvan on Melatonin Secretion
This study examines the effect of tetrahydrobiopterin (Kuvan) and Large Neutral Amino Acid (LNAA) therapy on melatonin and dopamine levels in individuals with Phenylketonuria (PKU).
- Trial name
- NCT01617070
- Testing
- Kuvan, Large Neutral Amino Acid Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders
The objective of this K01 study was to pilot a sequential, multiple assignment, randomized trial (SMART) design to compare the impact of a sequence of sleep interventions, based on participant treatment response, to optimize…
- Conditions
- Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Sleep Disturbance
- Trial name
- NCT03730194
- Testing
- Melatonin, Bedtime Bank
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Hemodialysis, Peritoneal Dialysis
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients
Sleep problems can lead to a bad quality of life and a raise of morbidity, also in dialysis patients. Sleep problems can be caused by a disturbance of circadian rhythms in our body.
- Conditions
- Hemodialysis, Peritoneal Dialysis, Sleep Problems
- Trial name
- NCT00404456
- Testing
- Melatonin
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Meander Medical Center
Critically Ill Adult Patients in Intensive Care Units
Effects of Patient-Directed Interactive Music Therapy on Sleep, Delirium and Melatonin Levels is Critically Ill Elderly Patients
(Background) Adults in intensive care units (ICU), especially elderly patients often suffer from a lack of sleep or frequent sleep disruptions due to physical, emotional stress such as pain, inflammation, and anxiety.
- Trial name
- NCT03156205
- Testing
- interactive music therapy, passive music listening, passive earphone-use
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Yonsei University
Neonatal Sepsis
Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis
Assess the efficacy of melatonin as an adjuvant in the treatment of free radical disease in septic preterms receiving melatonin compared to those on conventional treatment through measuring the level of Malondialdehyde as a…
- Trial name
- NCT03295162
- Testing
- Melatonin 10 mg, Conventional treatment of neonatal sepsis
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mohamed Hussein Metwally
Sleep, Healthy
Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep
A randomized, double-blind, placebo-controlled, cross-over pilot study to investigate the efficacy of Rest-ZZZ in healthy participants with difficulty falling asleep or staying a sleep. The study will have 3 study periods.
- Trial name
- NCT04093271
- Testing
- Rest-ZZZ, Active Comparator - Diphenhydramine HCl
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- LifeSeasons Inc.
Pharmacokinetics of Melatonin
The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers.
The circadian rhythm, the sleep-wake cycle, is mainly regulated by melatonin. The synthesis of melatonin is stimulated by the absence of light, leading to peak serum levels before bedtime.
- Trial name
- Melaform (NCT02107079)
- Testing
- Melatonin
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Utrecht University
Melatonin, Left Ventricular Function
Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension
This study aimed to evaluate the effect of melatonin on the left ventricular function in neonates with persistent pulmonary hypertension
- Conditions
- Melatonin, Left Ventricular Function, Neonates, Persistent Pulmonary Hypertension
- Trial name
- NCT07090720
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Chronic Kidney Disease
Circadian Rhythm of Erythropoietin And Melatonin in Renal Disease
Rationale: Investigation of the circadian rhythm of erythropoietin and melatonin in patients with various degrees of renal insufficiency Objectives: Primary objective: Is there a circadian rhythm of epo and melatonin in patients…
- Trial name
- CREAM 1 (NCT00698360)
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Meander Medical Center
Impacted Third Molar Tooth
The Effect of Melatonin Application Following Removal of Impacted Third Molar
In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic…
- Trial name
- NCT04424875
- Testing
- 3 mg melatonin
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Fayoum University
Healthy
A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults
A study comparing the pharmacokinetics of prolonged-release melatonin versus standard, immediate-release melatonin. Multiple blood draws over a 10-hour period will be analysed to determine the area under the curve, time to peak…
- Trial name
- NCT04067791
- Testing
- Prolonged-Release Melatonin, Immediate-Release Melatonin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Immediate Dental Implant
Evaluation of Melatonin Application of Immediate Dental Implant
The presence of periapical pathology, the absence of kera¬tinized tissue and lack of complete soft tissue closure over the extraction socket have been reported a drawbacks of immediate implant placement .
- Trial name
- NCT03689998
- Testing
- immediate implant placement, Melatonin
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Antioxidants, Oxidative Stress
The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport.
The research aims to determine the impact of 30-day supplementation of melatonin on the antioxidative defense mechanisms and the release of markers of oxidative stress and inflammation in rowers and footballers undergoing…
- Conditions
- Antioxidants, Oxidative Stress, Inflammation, Lipid Peroxidation
- Trial name
- NCT03505411
- Testing
- melatonin supplementation
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Nicolaus Copernicus University
Neonatal Diseases and Abnormalities, Neonatal Mortality
Melatonin for Pulmonary Hypertension in Full Term Neonates
Published evidence has provided a possible role of melatonin and the treatment of pulmonary hypertension through its strong antioxidant properties and improving vascular function in animals.
- Conditions
- Neonatal Diseases and Abnormalities, Neonatal Mortality, Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension, Children
- Trial name
- NCT06685679
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sleep Deprivation, Delirium
Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU
The purpose of this study is to analyze a multi-component sleep/wake protocol for optimization of environmental factors (noise, light, nursing activities) as well as non-environmental factors (pain, mechanical support devices…
- Trial name
- NCT03313115
- Testing
- Sleep/Wake Protocol
- Where
- United States
- Volunteers
- 685 people
- Sponsor
- University of Utah
Sleep Initiation and Maintenance Disorders
Efficacy and Safety of KI1001 in the Treatment of ≥ 55 Years Old Insomnia Patients
KI1001(Circadin®, Prolonged release tablet which contains melatonin) has showed its efficacy to improve sleep quality in over 55 years old primary insomnia patients.
- Trial name
- NCT02087722
- Testing
- KI1001
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Kuhnil Pharmaceutical Co., Ltd.