Clinical trials: Melatonin, completed
Pregnancy
Effects of Light on Melatonin and Contractions in Pregnant Women
Specific Aim: Test the hypothesis that ocular light exposure will suppress melatonin secretion and reduce uterine contractions in women at late term pregnancies. Secondary aim.
- Trial name
- NCT01863446
- Testing
- Lighting1, Lighting2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Biological Clock Dysfunction, Optic Nerve Hypoplasia
Biological Clock Dysfunction in Optic Nerve Hypoplasia
Background: Optic Nerve Hypoplasia (ONH) is a leading cause of blindness in children. For unclear reasons, the incidence of ONH is increasing, with ONH affecting about 1 in 10,000 live-born infants.
- Trial name
- NCT00825591
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Sleep Disorders
Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers
Routine sleep duration varies greatly among individuals. The biological meaning of this variation is unknown. The term circadian rhythm refers to the biological clock that regulates the timing of falling asleep, waking up, and…
- Trial name
- NCT00001546
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Developmental Delay Disorders, Chromosome Deletion
Treatment Strategies for Children With Smith-Magenis Syndrome
This study will examine the effect of bright light or melatonin treatment on sleep in children with Smith-Magenis syndrome (SMS), a genetic disorder characterized by certain physical, behavioral and developmental features.
- Conditions
- Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00506259
- Testing
- dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Dental Implants, Immediate Implant Placement
Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration
This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar…
- Conditions
- Dental Implants, Immediate Implant Placement, Osseointegration
- Trial name
- NCT07610876
- Testing
- Autologous Demineralized Dentin Graft, Melatonin gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Multiple Sclerosis, Relapsing-Remitting
Melatonin in Relapsing-Remitting Multiple Sclerosis Patients
The purpose of this study is to determine whether melatonin is effective in the treatment of relapsing-remitting multiple sclerosis patients as a supplement to the main disease-modifying drugs.
- Trial name
- NCT01279876
- Testing
- Melatonin
- Where
- Iran
- Volunteers
- 25 people
- Sponsor
- Tehran University of Medical Sciences
Infertility, Female, Polycystic Ovary Syndrome
Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
The aim of the study is to study the effect of an antioxidant food supplement associated with probiotics on the oocyte quality response, oxidative stress and microbiota function in an in vitro fertilization cycle in patients with…
- Trial name
- NCT04670393
- Testing
- FertyBiotic Woman Plus
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fertypharm
Postoperative Delirium
Association of Plasma Melatonin Levels With Delirium
Delirium is common complications in postoperative critically ill patients. However the mechanism of postoperative delirium is not well understood.The investigators designed a prospective observational study to investigate the…
- Trial name
- NCT01570881
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Okayama University
Sleep
Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations
Melatonin is a hormone that promotes sleep that is available without a prescription in the United States. In addition to oral supplements, melatonin can be purchased in the form of lotions and bubble baths with unknown dosage and…
- Trial name
- NCT06382610
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Redlands
Sleep
Tart Cherries and Melatonin Content
The aim of this investigation was to examine the effects of tart Montmorency cherry juice on urinary 6-sulfatoxymelatonin and sleep quality using a double-blind, placebo-controlled, cross-over design.
- Trial name
- NCT01528202
- Testing
- Cherry juice, Fruit juice cordial
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Phenylketonuria (PKU)
Effects of Kuvan on Melatonin Secretion
This study examines the effect of tetrahydrobiopterin (Kuvan) and Large Neutral Amino Acid (LNAA) therapy on melatonin and dopamine levels in individuals with Phenylketonuria (PKU).
- Trial name
- NCT01617070
- Testing
- Kuvan, Large Neutral Amino Acid Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Postoperative Pain
Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia
The investigators designed a randomized double-blind placebo-controlled trial to evaluate the effect of preoperative single dose of oral melatonin and vitamin C administration on postoperative analgesia in patients undergoing…
- Trial name
- NCT02639741
- Testing
- Melatonin, Vitamin C
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Cukurova University
Traumatic Brain Injury, Critical Illness
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity.
- Conditions
- Traumatic Brain Injury, Critical Illness, Sleep
- Trial name
- SMARTKids (NCT04932096)
- Testing
- melatonin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Sleep Quality, DNA Damage Repair Deficiency
Melatonin and DNA Damage Study
This research aims to determine if melatonin supplementation, through improvements in sleep quality, increases the ability to repair oxidative DNA damage and reduce lipid peroxidation levels among nightshift workers.
- Conditions
- Sleep Quality, DNA Damage Repair Deficiency, Oxidative Stress
- Trial name
- NCT03945955
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Circadian System
Beneficial Effects of Daytime Light Exposure and Physical Activity on the Human Circadian Clock and Sleep
This study is to examine the circadian phase-shifting effects of daylight and physical activity (primary endpoint: shift in dim-light melatonin onset (DLMO)) as well as their effects on sleep the ensuing night and analyzes how…
- Trial name
- DayCiS (NCT05513547)
- Testing
- LE protocol 1: exposure to artificial light, LE protocol 2: natural daylight, LE protocol 3: natural daylight with reduced short-wavelength proportions
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis, Knee
Melatonin for Knee Osteoarthritis Patients
By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population.
- Trial name
- NCT06012175
- Testing
- Melatonin
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xiangya Hospital of Central South University
Post Operative Delerium
The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries
The aim of this study is to illuminate the effect of combination of dexmedetomidine and oral melatonin versus the use of dexmedetomidine infusion alone on the improving of post-operative delirium (POD) on patients undergoing open…
- Trial name
- NCT07475156
- Testing
- Dexmedetomidine (DEX), Melatonin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Indications for Care in Pregnancy; Labor; and Delivery
Colostral Milk and Blood IL-6 Levels in Types of Labour
The comparison of serum and colostral melatonin, and IL-6 levels between women with vaginal delivery, emergency cesarean section and elective cesarean section
- Trial name
- NCT03953066
- Testing
- The calculation of blood IL-6 and coloctral milk melatonin
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Samsun Education and Research Hospital