Clinical trials: Melatonin, completed
Obstructive Sleep Apnea
The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea
Our hypothesis is that oxidative stress induced during repeated apneas in obstructive sleep apnea (OSA) patients alters the neural control of breathing which destabilizes ventilatory control and exacerbates OSA.
- Trial name
- NCT02484300
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Migraine
Melatonin for Migraine Prevention
The circadian system with its centre in the hypothalamus is involved in migraine pathophysiology. Whether it plays a pivotal role is not clarified.
- Trial name
- MMP (NCT00849511)
- Testing
- melatonin
- Where
- 2 sites in Norway
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Diabetes Mellitus, Type 2, Insomnia
A Study of the Efficacy of Prolonged-Release Melatonin Versus Placebo in Diabetic Patients Suffering From Insomnia
Objective - Type 2 uncontrolled diabetic patients often have low endogenous melatonin and suffer from sleep disorders. The effect of a prolonged-release melatonin (PRM) formulation on glucose lipid metabolism and sleep is studied…
- Trial name
- NCT00869128
- Testing
- Circadin
- Volunteers
- 36 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep Disorders
Does Melatonin Restore Sleep Architecture in Autistic Children
Although behavioral disorders origins in autistic children are still unclear, they seem to be influenced by sleep disorders. Results of studies performed on sleep quality in autistic children showed a high prevalence of sleep…
- Trial name
- SOMELIA (NCT01993251)
- Testing
- melatonin
- Where
- 5 sites in France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Alzheimer Disease, Dyssomnias
Study of Melatonin: Sleep Problems in Alzheimer's Disease
This protocol is a multicenter clinical trial of melatonin for sleep disturbances associated with Alzheimer's disease (AD). Frequent nocturnal awakening is a common behavioral symptom of AD.
- Trial name
- NCT00000171
- Testing
- Melatonin
- Where
- 31 sites in United States
- Sponsor
- National Institute on Aging (NIA)
Emergence Agitation
Melatonin for Pediatric Emergence Agitation
efficacy of melatonin premedication on emergence agitation in children undergoing herniorrhaphy surgeries
- Trial name
- NCT05223010
- Testing
- Melatonin 5 MG/15 ML Oral Solution 0.05 mg/kg, Melatonin 5 MG/15 ML Oral Solution 0.2mg/kg, Melatonin 5 MG/15 ML Oral Solution 0.4mg/kg
- Where
- Egypt
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Early Stage Breast Cancer
Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer
Investigators plan to carry out a study to investigate two different pills, Vitamin D and melatonin, and whether they can reduce the spread of cancer cells in the tumors of women with breast cancer.
- Trial name
- MELO-D (NCT01965522)
- Testing
- Melatonin, Vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Juravinski Cancer Center
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Glaucoma, Sleep Disturbance
Effects of Melatonin Supplementation on Sleep Quality in Patients With Advanced Glaucoma
A prospective, randomized, parallel, crossover, double-blind therapeutic clinical trial was conducted in accordance with the principles of the Resolution nº 466/12 of the National Health Council and was approved by the Ethics and…
- Conditions
- Glaucoma, Sleep Disturbance, Circadian Rhythm, Melatonin
- Trial name
- NCT06868745
- Testing
- Experimental: melatonin treatment group
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Sao Paulo
Sleep
Tart Cherries and Melatonin Content
The aim of this investigation was to examine the effects of tart Montmorency cherry juice on urinary 6-sulfatoxymelatonin and sleep quality using a double-blind, placebo-controlled, cross-over design.
- Trial name
- NCT01528202
- Testing
- Cherry juice, Fruit juice cordial
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Postoperative Pain
Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief
Seventy five patients, aged 18-50 years, ASA I and II undergoing elective single level lumber laminectomy under general anesthesia were included in this randomized controlled double-blind study.
- Trial name
- NCT02726126
- Testing
- Comparative study between transdermal fentanyl and melatonin patches on postoperative pain relief after lumber laminectomy
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Alzheimer's Disease, Sleep Disorder
Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor
The aim of this exploratory randomized, placebo controlled study is to evaluate the efficacy of Circadin® 2mg in patients with mild to moderate Alzheimer Disease (AD) treated with the acetylcholinesterase (AChE) inhibitor.
- Trial name
- NCT00940589
- Testing
- Circadin
- Where
- 6 sites in United States, Israel and 1 more
- Volunteers
- 73 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Urological Surgery
Effect of Melatonin Patches on Sleep in Urological Surgery
Patients undergoing urological surgery may experience a decrease in sleep quality due to many factors such as hospitalization, different environment, pain, stress and anesthesia.
- Trial name
- NCT06910345
- Testing
- A skin patch (2.1 mg melatonin) was applied to the melatonin group. The melatonin patches will be placed at 8:00 PM (on the upper chest or forearm, as determined by the patient) before going to sleep
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlas University
Bioavailability
Bioavailability and Bioactivity of Red Wine Melatonin in Humans
Melatonin (MLT) is a bioactive compound in red wine. The investigators will investigate the serum and salivary concentrations and antioxidant power of MLT after the intake of a glass of red wine.
- Trial name
- Wine-MLT (NCT02767102)
- Testing
- Red wine with melatonin, Red wine without melatonin
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Milan
Seasonal Affective Disorder
Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder
As the seasons change during the course of the year, many animals show major changes in their behavior and physiology. Many of these changes are triggered by changes in the length of time each night that the pineal gland produces…
- Trial name
- NCT00001485
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Kidney Diseases
Renal Effects of Melatonin Trial in Chronic Kidney Disease
This will be a prospective, double blinded, randomized, controlled pilot study to determine if there is any correlation between melatonin administration and proteinuria.
- Trial name
- REM (NCT04336566)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Oklahoma
Atopic Dermatitis
Effectiveness of Melatonin for Sleep Disturbances in Children With Atopic Dermatitis
Sleep disturbance is a common complaint among patients with atopic dermatitis(AD). Melatonin may aid sleep and also has anti-inflammatory properties, and has been suggested in managing sleep disturbance in AD patients.
- Trial name
- NCT01638234
- Testing
- Melatonin
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Postural Instability
Investigation of Melatonin and Zolpidem Effect on Postural Instability in Healthy Adult Subjects
This is a randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on night time awakening body sway of melatonin and zolpidem in healthy adult subjects aged of 55 to 64 years.
- Trial name
- NCT01280734
- Testing
- Circadin (R) 2 mg, Stilnox (R) 10 mg
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep
A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity
This study will evaluate the efficacy of Asutra's 'Dream the night away' nighttime lotion with melatonin and magnesium on sleep health in terms of quantity, quality, ease of falling asleep or falling back asleep after waking in…
- Trial name
- NCT06146712
- Testing
- Asutra's 'Dream the night away' nighttime lotion
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Asutra
Sleep Problems
Assessment of the Pharmacokinetics of Circadin® in Children With Neurodevelopmental Disorders and Sleep Disturbances
There is increasing evidence that chronic sleep disorders in children with autism spectrum disorder (ASD), Angelman Syndrome (AS) and Smith-Magenis syndrome (SMS) are associated with disturbed melatonin secretion and melatonin…
- Trial name
- NCT01903681
- Testing
- Circadin 2 mg, Circadin 10 mg
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Neurim Pharmaceuticals Ltd.