Clinical trials: Melatonin
PreDiabetes
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species…
- Trial name
- NCT03848533
- Testing
- melatonin, metformin
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- University of Guadalajara
Sleep, Mood
Tryptophan Supplementation to Improve Night Shift Workers' Health
This randomized cross-over double-blinded trial aims to investigate the health effect of oral l-tryptophan supplementation on workers who rotate night shift work, and to examine the influences of different frequencies and timings…
- Conditions
- Sleep, Mood, Burnout, Melatonin Deficiency
- Trial name
- NCT04505800
- Testing
- Tryptophan supplement, Maltose
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Alzheimer Disease, Agitation,Psychomotor
Clinical Trial on Agitation in Alzheimer's Dementia
The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from…
- Conditions
- Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
- Trial name
- CALMA (NCT05543681)
- Testing
- IGC-AD1-Active
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 164 people
- Sponsor
- IGC Pharma, LLC
Newborn Morbidity, Oxidative Stress
Antioxidant Effects of Melatonin in Preterm
Preterm infants are at risk of free radical mediated diseases from oxidative stress (OS) injury. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals.
- Conditions
- Newborn Morbidity, Oxidative Stress, Pre-Term, Melatonin Deficiency
- Trial name
- NCT04785183
- Testing
- Melatonin drops
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Very Low Birth Weight Infant
The Effect of Family Integrated Care on Melatonin Level in Very Low Birth Weight Infants
This study will explore the effect of Family integrated care (FICare) on the level of melatonin and other clinical outcomes in very low birth weight infants (VLBWIs) by integrating families into the neonatal intensive care unit…
- Trial name
- NCT05483231
- Testing
- Family integrated care intervention group, Routine nursing care group
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Children's Hospital of Fudan University
Agitation
Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine
Emergence agitation (EA) is common after nasal surgery under general anesthesia, which can lead to several problems, such as increased risk of injury to the patient or medical staff, pain, decreased patient satisfaction…
- Trial name
- NCT04908605
- Testing
- Mirtazapine, Melatonin
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Ain Shams University
Melanoma (Skin Cancer), NSCLC (Non-small Cell Lung Cancer)
Bright Light Therapy in Patients With Melanoma or Non-small Cell Lung Cancer (NSCLC) Who Are Receiving First-Line Immune Checkpoint Blockade
This study is being done to test whether bright light therapy can be used to synchronize patients' circadian rhythms and allow ICB (immune-checkpoint blockade) therapy to be administered at a time in the circadian rhythm that…
- Trial name
- IIT BLT (NCT07661966)
- Testing
- Bright Light Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Light Therapy for Elderly Depression
The purpose of this study is to investigate the following two hypotheses: 1. Treatment with bright light improves their sleep, mood, concentration and self-sufficiency of elderly depressed subjects.
- Trial name
- NCT00332670
- Testing
- 10.000lux blue 1 hour every day during three weeks, 50lux dim red 1 hour every day during three weeks
- Where
- Netherlands
- Volunteers
- 89 people
- Sponsor
- GGZ Buitenamstel
Sleep Disorders, Circadian Rhythm, Craniopharyngioma
Sleep Wake and Melatonin Pattern in Craniopharyngioma
The hypothalamus is a part of the brain containing a number of nuclei with a variety of functions. It is central in the regulation of hormone secretion, sleep, and circadian functions.
- Trial name
- NCT01881854
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lennox-Gastaut Syndrome
Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
Lennox-Gastaut syndrome is a severe epileptic encephalopathy of childhood. In that syndrome, various type of seizure occur, mainly tonic seizures, atonic seizures and atypical absences. The tonic seizure occur mostly at night.
- Trial name
- NCT01370486
- Testing
- melatonin
- Where
- Switzerland
- Sponsor
- Institution de Lavigny
Perimenopause
Myo-inositol Plus Melatonin in Perimenopausal Women
Menopause is the milestone of a more broaden condition that can last up to 10 years. The first menopausal symptoms usually appear around the age of 42 and are characterized by a gradual decline in thyroid and gonadal function…
- Trial name
- NCT01325389
- Testing
- Myo-Mel
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Sleep
A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity
This study will evaluate the efficacy of Asutra's 'Dream the night away' nighttime lotion with melatonin and magnesium on sleep health in terms of quantity, quality, ease of falling asleep or falling back asleep after waking in…
- Trial name
- NCT06146712
- Testing
- Asutra's 'Dream the night away' nighttime lotion
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Asutra
Sleep Disturbance, Sleep Quality
A Exploratory Study of NatureU Sweet Dream on Sleep Outcomes
This was a single-center, open-label, exploratory self-controlled study evaluating NatureU Sweet Dream on sleep outcomes in adults with mild to moderate sleep disturbance.
- Trial name
- NUSD (NCT07600528)
- Testing
- NatureU Sweet Dream, Commercially Available Melatonin Product
- Where
- China
- Volunteers
- 17 people
- Sponsor
- OmniSolutions Laboratory Holdings Limited
Polycystic Ovary Syndrome
Effects of Melatonin in PCOS Women
The aim of our study is to investigate the effects of a treatment with melatonin on clinical, endocrine and metabolic features in women affected by PCOS.
- Trial name
- NCT02663570
- Testing
- Melatonin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Diabetes, Glucose Tolerance
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene
The effect of 3 months of melatonin 4mg treatment on glucose tolerance in different variants of the melatonin receptor 1B gene will be evaluated.
- Trial name
- MELAG (NCT01705639)
- Testing
- Melatonin
- Where
- 2 sites in Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
ST-segment Elevation Myocardial Infarction
Association Between Plasma Melatonin and No-reflow
ST-segment elevation myocardial infarction (STEMI) is an acute manifestation of coronary heart disease, remaining a frequent cause of death.
- Trial name
- NCT03306303
- Volunteers
- 1,700 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain
Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery.
The goal of this clinical trial is to compare the analgesic effect of melatonin, and vitamin C and their combination in patients aged 18-60 years old who will undergo major abdominal surgery with mid-line incision within an…
- Trial name
- NCT06374771
- Testing
- Melatonin 10 MG, Vitamin C
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Alveolar Bone Loss
Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
Background: Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and secreted by the pineal gland and other organs, such as the retina, bone marrow, and intestines in a circadian pattern.
- Trial name
- NCT04229719
- Testing
- N-acetyl-5-methoxytryptamine
- Where
- Iraq
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Epilepsy, Electroencephalogram
The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children
This study aims to determine the safety and effectiveness of oral melatonin as natural inducer of sleep to acquire useful EEGs in South African children following its introduction as the main agent used in the Neurophysiology…
- Conditions
- Epilepsy, Electroencephalogram, Children, Sedation
- Trial name
- NCT02195661
- Testing
- Melatonin, Chloral Hydrate
- Where
- South Africa
- Volunteers
- 194 people
- Sponsor
- University of Cape Town