Clinical trials: Melatonin, completed
Type 1 Diabetes (T1D)
Effect of Melatonin Supplementation on Excecutive Functions, Sleep Quality and Glycemic Metrics Among Adolescents With Type 1 Diabetes Mellitus
Cognitive impairment, poor sleep quality, Alzheimer's disease and dementia are complications of uncontrolled type 1 diabetes (T1D).
- Trial name
- MS642/2024 (NCT07592442)
- Testing
- Melatonin tablet 3 mg once daily
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Pregnancy
Melatonin in Pregnancy
Melatonin is well known for its role in the sleep-wake cycle and is synthesised in response to low light levels from the pineal gland.
- Trial name
- MEL-P2 (NCT03609086)
- Testing
- Melatonin analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Aberdeen
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Melatonin vs Metoprolol or Dexmedetomidine to Improve Surgical Field in FESS
This randomized controlled study at Zagazig University Hospitals will include 112 patients undergoing elective functional endoscopic sinus surgery, allocated into four groups (Melatonin, Metoprolol, Dexmedetomidine, Control).
- Trial name
- NCT07568873
- Testing
- Melatonin, Metoprolol (MET), Dexmedetomidine
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Zagazig University
Clinical Trial
Optimal Dosage of Melatonin for Preoperative Sedation in FESS
To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
- Trial name
- FESS (NCT07550751)
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Back Pain Lower Back Chronic, Insomnia
Melatonin fOr CHronic bAck Pain (The MOCHA Trial)
According to the World Health Organization (WHO) Global Burden of Disease study, back pain is one of the conditions impacting disability the most worldwide.Pain medication use in patients with chronic back pain is substantial…
- Trial name
- MOCHA (NCT06476392)
- Testing
- Melatonin 10 MG
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Odense University Hospital
Post Operative Delerium
The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries
The aim of this study is to illuminate the effect of combination of dexmedetomidine and oral melatonin versus the use of dexmedetomidine infusion alone on the improving of post-operative delirium (POD) on patients undergoing open…
- Trial name
- NCT07475156
- Testing
- Dexmedetomidine (DEX), Melatonin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Glucose, Circadian Rhythm
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT02642640
- Testing
- melatonin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative, Narcotic Use
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery
The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption.
- Trial name
- NCT04791943
- Testing
- Melatonin 10 MG, Lactose pill
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
- Trial name
- NCT06404086
- Testing
- Modafinil, Solriamfetol, Melatonin
- Where
- 47 sites in United States
- Volunteers
- 830 people
- Sponsor
- Duke University
Infertility, Infertility (IVF Patients)
Melatonin Supplementation in Ovarian Response
Melatonin is a potent antioxidant, has been proposed to improve ovarian response and oocyte quality in assisted reproductive technologies (ART).
- Conditions
- Infertility, Infertility (IVF Patients), Infertile Women Undergoing IVF or ICSI
- Trial name
- NCT07343947
- Testing
- 5mg melatonin supplementation
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Urological Surgery
Effect of Melatonin Patches on Sleep in Urological Surgery
Patients undergoing urological surgery may experience a decrease in sleep quality due to many factors such as hospitalization, different environment, pain, stress and anesthesia.
- Trial name
- NCT06910345
- Testing
- A skin patch (2.1 mg melatonin) was applied to the melatonin group. The melatonin patches will be placed at 8:00 PM (on the upper chest or forearm, as determined by the patient) before going to sleep
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlas University
Osteoarthritis, Knee
Melatonin for Knee Osteoarthritis Patients
By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population.
- Trial name
- NCT06012175
- Testing
- Melatonin
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xiangya Hospital of Central South University
Sedation for Children Undergoing MRI
A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI
The patients will be randomized into 2 equal groups by a computer-generated random numbers table, named group A, B. Group A: will receive oral Melatonin and nasal Sevoflurane.
- Trial name
- NCT06606899
- Testing
- Melatonin 3 MG, Chloral Hydrate, Sevoflurane
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Perimenopausal Disorder
Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause
Menopause is defined as the absence of menstruation for 12 months without a pathological cause and it is marked by physical fluctuations and biological changes that can impact women's quality of life.
- Trial name
- NCT06192641
- Testing
- Melatonin 3 MG
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Univates
Dental Anxiety, Children
The Efficacy of Melatonin Patches on Dental Anxiety in Children
Statement of Problem: Dental anxiety significantly impacts dental treatment outcomes, particularly in pediatric patients. Given the side effects associated with current oral anxiolytic medications, there is a need to clinically…
- Trial name
- NCT07162272
- Testing
- Melatonin Patches
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sleep Disorders
Does Melatonin Restore Sleep Architecture in Autistic Children
Although behavioral disorders origins in autistic children are still unclear, they seem to be influenced by sleep disorders. Results of studies performed on sleep quality in autistic children showed a high prevalence of sleep…
- Trial name
- SOMELIA (NCT01993251)
- Testing
- melatonin
- Where
- 5 sites in France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Healthy, Dietary Bioavailability
Effect of Fruit Elicitation With Melatonin on Human Health
The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up by the body.
- Conditions
- Healthy, Dietary Bioavailability, Plant Extracts, Phenolic Compounds
- Trial name
- NCT07192835
- Testing
- Juice from untreated control fruits, Juice from melatonin-treated fruits
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Sleep
The Effectiveness of a Proprietary of a Botanical Extract on Sleep Quality
The purpose of this study is to evaluate the efficacy and superiority of a botanical based sleep product on sleep quality as compared to melatonin, among healthy female participants.
- Trial name
- NCT06894108
- Testing
- Proprietary Blend of Botanical Extracts, Melatonin
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Post-operative Delirium, Major Non-cardiac Surgery
MIND After Surgery
Delirium is the most common neurological adverse outcome in elderly surgical patients. It is associated with an increased mortality and morbidity, including need for prolonged hospital stay and institutional care.
- Trial name
- MIND (NCT03785158)
- Testing
- Liquid Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- McMaster University
Hypohidrotic Ectodermal Dysplasia
Impact of Dysregulation of Core Body Temperature on Sleep in Patients With Hypohidrotic Ectodermal Dysplasia
The aim of the study is to compare sleep efficiency by means of actigraphy in patients with hypohidrotic ectodermal dysplasia with healthy controls.
- Trial name
- DEH-Somno (NCT05378932)
- Testing
- Actigraphy, Recording of proximal and distal skin temperature and temperature of the bedroom, Questionnaires assessing subjective sleep quality
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris