Clinical trials: Melatonin, completed
Severe Covid-19
Safety and Efficacy of Medications COVID-19
We performed a quasi-experimental open-label pragmatic study alternating standard of care (SOC) and oral bedtime melatonin (OBM) at different high doses over 4 consecutive time periods enrolling all consecutive RT-PCR SARS-CoV-2…
- Trial name
- NCT05596617
- Testing
- Oral bedtime melatonin
- Where
- Spain
- Volunteers
- 335 people
- Sponsor
- Hospital San Carlos, Madrid
Pregnancy
Effects of Light on Melatonin and Contractions in Pregnant Women
Specific Aim: Test the hypothesis that ocular light exposure will suppress melatonin secretion and reduce uterine contractions in women at late term pregnancies. Secondary aim.
- Trial name
- NCT01863446
- Testing
- Lighting1, Lighting2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Disorder
Evning Exposure to Computer Screen Disrupts Sleep, Attention and Biological Rhythms
Light exposure is on the rise in recent years. In large part because of unintentional illumination from screens that emit light directly into the eyes.
- Trial name
- NCT02957383
- Testing
- Wavelength, Intensity
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Post Partum Haemorrhage in Patients Undergoing Cesarean Section
Evaluation of Melatonin's Effect on Pain and Blood Loss After Cesarean Section
The purpose of this study is to assess the effect of melatonin on pain and amount of blood loss after cesarean delivery one hundred twenty women with singleton term pregnancy undergoing elective or emergency lower segment…
- Trial name
- NCT01572805
- Testing
- melatonin 3mg, melatonin 6mg
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Qazvin University Of Medical Sciences
Sleep Disorders, Circadian Rhythm, Craniopharyngioma
Sleep Wake and Melatonin Pattern in Craniopharyngioma
The hypothalamus is a part of the brain containing a number of nuclei with a variety of functions. It is central in the regulation of hormone secretion, sleep, and circadian functions.
- Trial name
- NCT01881854
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Delirium in Old Age
Melatonin for Post Operative Delirium Prevention in Elderly Patients
The present study will evaluate the role of melatonin prophylaxis in delirium prevention in elderly patients undergoing colorectal procedures.
- Trial name
- NCT05640934
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Migraine in Adolescents
Bringing Relief to Adolescents Naturally Using Melatonin for Migraine
Migraine in adolescents is common and effective and safe preventive treatments are needed. This is a pilot randomized controlled trial of melatonin versus placebo for migraine prevention in adolescents 12-17 years old.
- Trial name
- BRAiN-M (NCT02344316)
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Amy Gelfand
Bipolar Disorder
Circadian Phase in Bipolar Depression: Is it Delayed and Does it Normalize With Remission?
The overall aim of this project is to compare sleep patterns and melatonin profiles in individuals with bipolar disorder during depression and after remission.
- Trial name
- NCT01784341
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Alternating Hemiplegia
Observe Alternating Hemiplegia of Childhood (OBSERV-AHC) Study
Alternating Hemiplegia of Childhood (AHC) is a rare and serious disease that is in need of effective, and hopefully even curative, therapies.
- Trial name
- OBSERV-AHC (NCT04020848)
- Testing
- Review of past medical history, clinical exam, and electroencephalogram, polysomnography and urine samples of melatonin and pupillometry., The patients' parents have to complete the VINELAND II adaptive behavior scales scoring, The Sleep Disturbance Scale for Children (SDSC) and Horne & Ostberg Circadian Typology Questionnaire
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon
Physical Exercise, Sleep Disturbance
Treatment of Sleep Disturbance in Children With ASD
This RCT study aims to compare effectiveness physical exercise and melatonin supplement on treating sleep disturbance in children with ASD.
- Conditions
- Physical Exercise, Sleep Disturbance, Autism Spectrum Disorder, Melatonin Deficiency
- Trial name
- NCT04878198
- Testing
- Jogging program, Melatonin supplement intervention
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- Education University of Hong Kong
Melatonin Deficiency
Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia
Background: The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, with consideration of Helicobacter infection.
- Trial name
- NCT04352062
- Testing
- Melatonin, Pantoprazole 40mg, Amoxicillin
- Where
- Poland
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Advanced Stage Cancer
Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial
Meta-analysis of previous studies have shown that melatonin is a beneficial adjutant for reducing chemotherapy-induced toxicity; however no randomized, double-blind, placebo controlled trials have been conducted.
- Trial name
- MIRCIT (NCT01706627)
- Testing
- 10 mg Melatonin, 20 mg Melatonin
- Where
- 2 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- Khon Kaen University
Biological Availability
Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally (MELATONIN)
Sleep disorders represent an important public health problem that cause important personal problems, absenteeism and considerable health costs.
- Trial name
- MELATONIN (NCT03951025)
- Testing
- Melatonin oral administration, Melatonin sublingual administration
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Hypohidrotic Ectodermal Dysplasia
Impact of Dysregulation of Core Body Temperature on Sleep in Patients With Hypohidrotic Ectodermal Dysplasia
The aim of the study is to compare sleep efficiency by means of actigraphy in patients with hypohidrotic ectodermal dysplasia with healthy controls.
- Trial name
- DEH-Somno (NCT05378932)
- Testing
- Actigraphy, Recording of proximal and distal skin temperature and temperature of the bedroom, Questionnaires assessing subjective sleep quality
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontal Disease, Melatonin
Adjunctive Topical Melatonin Gel in Non-Surgical Periodontal Therapy for Periodontitis
The goal of this clinical trial is to evaluate the clinical effectiveness of adjunctive topical melatonin gel when used with non-surgical periodontal therapy (NSPT) in adult patients with periodontitis.
- Trial name
- NCT07605767
- Testing
- Topical 5% Melatonin Gel
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Circadian Rhythm Disruption, Healthy Volunteers
Cronobióticos Naturales
Brief Summary The goal of this clinical trial is to learn if a drink made from native berries of southern Chile can change the body's natural production of melatonin (a hormone that helps control sleep), sleep quality, and some…
- Trial name
- ChronoNaturals (NCT07848464)
- Testing
- Chronobiotic
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián
Sleep Disorder (Healthy Volunteers)
Study to Evaluate Improvements of the Quality of Sleep With NOVANUIT® Triple Action in Healthy Volunteers With Sleep Disorders
Primary Objective: To estimate the range of improvement of NOVANUIT® triple action on sleep quality global score. Secondary Objectives: To estimate the range of improvement of NOVANUIT® triple action on following parameters: time…
- Trial name
- NCT03514732
- Testing
- MELATONIN (MELATL07959)
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sanofi
Obesity
Effect of Melatonin on Oxidative Stress in Obese Adults (MELASTRESSOB)
The present research project aims to evaluate oxidative stress in a cohort of obese adults, subjected to an in-hospital 3-week multidisciplinary body weight reduction program (BWRP) with or without melatonin.
- Trial name
- MELASTRESSOB (NCT05759429)
- Testing
- BWRP, BWRP + melatonin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
The purpose of this study is to test the effect of oral melatonin supplementation (24 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114373
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Insomnia
Mechanisms of Sleep Latency and Health: The Effect of a Melatonin Receptor Agonist in Inflammation and Insulin Resistance
The purpose of this study is to help scientist better understand the effect of a 12-week single daily evening dose of ramelteon (Rozerem ©), a drug that has been approved by the U. S.
- Trial name
- NCT02156271
- Testing
- ramelteon
- Volunteers
- 75 people
- Sponsor
- Duke University