Clinical trials: Melatonin, completed
Cervical Cancer, Radiotherapy Side Effect
Circadian as A Prognostic Factor For Radiation Response in Cervical Cancer
The study was a Randomized Clinical Trial (RCT) or clinical trial comparing the results of radiation treatment of 2 treatment groups, i.e.
- Trial name
- NCT05511740
- Testing
- Afternoon Radiation
- Volunteers
- 71 people
- Sponsor
- Universitas Indonesia
Cardiac Surgery
Postoperative Melatonin Administration and Delirium Prevention in Patients Undergoing Vascular and Cardiac Surgery
The investigators plan to evaluate the effect of postoperative melatonin administration on postoperative delirium in patients undergoing vascular and cardiac surgery.
- Trial name
- NCT01198938
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Circadian Disruption
Evaluation of Circadian OS Technology on Melatonin Suppression
Primary Objective: Evaluate how the Circadian OS iPad-based light intervention suppresses melatonin. This small pilot study is designed to validate the Circadian OS technology by testing physiological response using melatonin…
- Trial name
- NCT07095270
- Testing
- Circadian OS software
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sleep Initiation and Maintenance Disorders
Effects of Melatonin on Insomnia Symptoms in Older Adults
This study will determine whether melatonin tablets will increase the sleep of older adults with insomnia.
- Trial name
- NCT00230737
- Testing
- Melatonin 0.4 mg, Melatonin 4.0 mg
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Nalaka Gooneratne
Coronary Artery Calcification
Melatonin and Coronary Artery Calcification
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
- Trial name
- NCT03967366
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Chinese PLA General Hospital
Non-24 Hour Sleep-Wake Disorder, Blindness
Efficacy and Safety of Circadin for Non-24 Hour Sleep-Wake Disorder in Totally Blind Subjects
The aim of this placebo-controlled randomized study was to evaluate the efficacy of Circadin™ 2 mg in improving total night sleep duration and stabilizing the circadian clock phase in totally blind subjects with non-24 hour…
- Trial name
- NCT00972075
- Testing
- melatonin (Circadin)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
TBI (Traumatic Brain Injury)
The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol
This study assess the effect of administration of exogenous melatonin as adjuvant to propofol on the level of sedation and consequently the rate of propofol infusion.
- Trial name
- NCT04034771
- Testing
- Melatonin 10 MG Oral Tablet, Propofol
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Back Pain Lower Back Chronic, Insomnia
Melatonin fOr CHronic bAck Pain (The MOCHA Trial)
According to the World Health Organization (WHO) Global Burden of Disease study, back pain is one of the conditions impacting disability the most worldwide.Pain medication use in patients with chronic back pain is substantial…
- Trial name
- MOCHA (NCT06476392)
- Testing
- Melatonin 10 MG
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Odense University Hospital
Sleep Disturbance, Insomnia
The Use of Amber Glasses in Improving Sleep
The use of amber glasses will aid the patient to fall asleep without the need for the use of hypnotic medication.
- Trial name
- NCT04751019
- Testing
- Amber Glasses
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Surrey and Borders Partnership NHS Foundation Trust
Healthy Adult Subjects, Healthy Elderly Subjects
Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers
This is the first clinical trial to evaluate ascending multiple oral doses in healthy adult and healthy elderly subjects to characterize the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BIIB118
- Trial name
- NCT02691702
- Testing
- BIIB118, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Biogen
Delayed Sleep Phase Disorder, Jet-lag
Melatonin Treatment for Induced Transient Insomnia
Melatonin supplements have been reported to be an effective treatment for circadian rhythm sleep disorders, including shift work dyssomnia, jet-lag, delayed sleep phase syndrome, and sleep disruption suffered by many blind…
- Conditions
- Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
- Trial name
- NCT00950885
- Testing
- Low Dose Melatonin, High Dose Melatonin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epilepsy, Insomnia
Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities
The purpose of the study is to evaluate the safety and efficacy of oral melatonin in improving sleep continuity in children with epilepsy and neurodevelopmental delay who have chronic insomnia by comparing Fast Release Melatonin…
- Conditions
- Epilepsy, Insomnia, Developmental Disability
- Trial name
- NCT01161108
- Testing
- Fast Release Melatonin (FR MLT), Timed Release Melatonin (TR MLT)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Circadian Rhythm Disorders, Anxiety
Circadian Disturbances After Breast Cancer Surgery
The purpose of this study is to investigate circadian disturbances after breast cancer surgery by means of monitoring sleep and heart-rate variability, by measuring a metabolite of melatonin in urine and by questionnaires and a…
- Conditions
- Circadian Rhythm Disorders, Anxiety, Breast Cancer
- Trial name
- CIRCA (NCT01171508)
- Testing
- Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring Inc, New York, USA, Polysomnograph - Embla A10 (Medcare, Reykjavik, Iceland), Holter monitor - Medilog AR12 (Oxford Instruments, Oxford, England)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Melissa Voigt Hansen
Hepatopathy
The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment
Introduction. Statins are generally well tolerated but not devoid of side effects. Quite often it is manifested by asymptomatic increase in the level of aspartate and alanine aminotransferase.
- Trial name
- NCT03121521
- Testing
- Melatonin 10 mg
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Post-operative Delirium, Major Non-cardiac Surgery
MIND After Surgery
Delirium is the most common neurological adverse outcome in elderly surgical patients. It is associated with an increased mortality and morbidity, including need for prolonged hospital stay and institutional care.
- Trial name
- MIND (NCT03785158)
- Testing
- Liquid Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- McMaster University
Critically Ill Patients, Mechanically Ventilated Patients
Oral Melatonin in Critically Ill High-risk Patients
Sleep disruptions are extremely common in high-risk critically ill patients. The investigators want to analyse oral melatonin potentialities as a sedative and a free-radicals scavenger for critically ill patients, and secondarily…
- Trial name
- NCT00470821
- Testing
- Oral melatonin 3mg BID
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- University of Milan
Pineal Tumor
Melatonin Replacement Therapy in Pinealectomized Patients
This is an open-label, single-arm, single-center, proof-of-concept study to assess the effects of melatonin on cardiac autonomic activity in melatonin non-proficient pinealectomized patients.
- Trial name
- NCT03885258
- Testing
- Melatonin Replacement Therapy
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo
Healthy, Dietary Bioavailability
Effect of Fruit Elicitation With Melatonin on Human Health
The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up by the body.
- Conditions
- Healthy, Dietary Bioavailability, Plant Extracts, Phenolic Compounds
- Trial name
- NCT07192835
- Testing
- Juice from untreated control fruits, Juice from melatonin-treated fruits
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Smoking, Vascular System Injuries
Melatonin in Smoke-induced Vascular Injury
The main purpose of this study was to evaluate the effects of melatonin in the regulation of the vascular injury in smokers through population-based, randomized, double-blind, placebo-controlled trial.
- Trial name
- NCT02591238
- Testing
- non-smoker oral melatonin, smoker oral melatonin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Postoperative Sleep Disturbances
Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality İn Rhinoplasty
Background Postoperative sleep disorders are common complications of surgery and anesthesia that prolong morbidity and hospital stay. Various methods are being explored to prevent and treat these issues.
- Trial name
- NCT06898463
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine), Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Konya City Hospital