Clinical trials: Melatonin, completed
Amyotrophic Lateral Sclerosis ALS
ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments
GenieUs developed an analysis platform that will be tested to separate study participants with ALS into four categories based on blood work.
- Trial name
- NCT06429059
- Testing
- Astaxanthin, Protandim, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Impacted Mandibular Third Molar
The Effect of Topical Application of Hyaluronic Acid and Melatonin Mixture Following Surgical Extraction of Impacted Mandibular Third Molars .
This randomized controlled clinical trial aims to evaluate the clinical and radiographical effects of the application of a mixture of hyaluronic acid and melatonin after surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07735806
- Testing
- Hyaluronic acid and Melatonin mixture, Gel foam
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Oral Mucositis (Ulcerative) Due to Radiation
Melatonin for Prevention of Radiation Induced Oral Mucositis
The main aim of this study was to evaluate the effectiveness of melatonin in prevention of radiation induced oral mucositis clinically and biochemically.
- Trial name
- NCT03833570
- Testing
- Rapid Release Capsules Melatonin, 10 mg, Miconaz oral gel, BBC oral spray
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Covid19, SARS-CoV Infection
The Effect of Melatonin and Vitamin C on COVID-19
This is a double-blind placebo controlled trial that seeks to evaluate the impact of melatonin and vitamin C on symptoms and outcomes of patients with COVID-19.
- Trial name
- NCT04530539
- Testing
- Vitamin C, melatonin, Symptom Survey
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Circadian Rhythm
Pistacho and Sleep Quality
The goal of this study is to evaluate the effect of pistachio (Pistacia vera L.) consumption on plasma melatonin, antioxidant capacity, and circadian rhythms in overweight young adults.
- Trial name
- PistaSleep (NCT07651605)
- Testing
- Pistacho supplementation
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Queretaro
Poor Quality Sleep
Honey to Improve Sleep Quality: a Feasibility Study
Inadequate sleep quality and duration may result in adverse health outcomes and poorer quality of life. Despite the availability of behavior modification and pharmaceuticals to aid sleep optimization and quality approximately 50%…
- Trial name
- NCT03567395
- Testing
- Melatonin, Honey
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Intermittent Hypoxia
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Trial name
- NCT03588676
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Robert L. Owens
Huntington Disease
Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study
The purpose of the study is to evaluate the efficacy of exogenous melatonin in improving sleep quality in HD gene carriers.
- Trial name
- NCT04421339
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Sleep Disturbance
- Trial name
- NCT06404112
- Testing
- Melatonin, Tailored lighting (TL) Active
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Melatonin Bioavailability
Kinetic of Melatonin Subsequent to the Consumption of Melatonin-rich Food Supplements
This study is conducted to clinically document the melatonin bioavailability of two dietary supplements containing melatonin : one prolonged release tablet dosed at 1.9mg and one spray dosed at 1mg for 2 oral sprays.
- Trial name
- NCT04574141
- Testing
- a prolonged release tablet and a spray containing melatonin
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- PiLeJe
Sleep Onset Latency, Sleep Quality
Efficacy of Dietary Supplementation With Melatonin in Targeting Sleep Quality
single-center, randomized, cross over, double-blind, placebo controlled intervention study
- Trial name
- NutriSom-01A (NCT06600633)
- Testing
- 14 days of intervention with Active Control (AC), 14 days of intervention with Test Product (TP)
- Where
- Slovenia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Carotid Stenosis
Melatonin in Patients Under Carotid Endarterectomy
The main purpose of this study is to evaluate the effects of melatonin in the regulation of the vascular injury in patients under carotid endarterectomy through population-based, randomized, double-blind, placebo-controlled trial.
- Trial name
- NCT03115034
- Testing
- Melatonin, blank
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Pre-menopausal Irregular Cycles and Bleedings
Myo-inositol and Melatonin in Pre-menopausal Women
The purpose of this study is to determine whether myo-inositol and melatonin, or myo-inositol alone, or melatonin alone, are effective in normalizing irregular bleeding and anovulatory cycles in pre-menopausal women.
- Trial name
- NCT01115127
- Testing
- melatonin, myo-inositol, melatonin plus myo-inositol
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Messina
Cranial Nerve Diseases
: Association of Melatonin Levels and Light and Noise Isolation in ICU
Melatonin is secreted from the epiphyseal gland with a circadian rhythm and is known to be anti-inflammatory. In this study, it is planned to investigate the effect of sleep disruptions on melatonin levels and inflammation…
- Trial name
- NCT03659760
- Testing
- Group Isolated
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Sleep
Improving Sleep in the Neurology In-Patient Population
We aim to test multiple interventions to improve sleep for Neurology inpatients, including 1) a sleep-friendly order set, and 2) a sleep menu.
- Trial name
- I_SLEEP (NCT06094699)
- Testing
- Sleep friendly order set, Patient sleep menu
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Cerebral Palsy, Melatonin
Melatonin for Cerebral Palsy Children's Sleep and Health
The present study was prospective uncontrolled, single-armed and un-blinded study. Held in the Pediatric neurology clinic, Children's hospital l, Faculty of Medicine, Ain Shams University from June 2016 to June 2018 of 24 months…
- Conditions
- Cerebral Palsy, Melatonin, Growth, Children, Only
- Trial name
- NCT04392063
- Testing
- Melatonin 3 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Anxiety
Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone
Background: Benzodiazepine, a common premedicant, suppresses endogenous melatonin levels and thus paradoxically increases episodes of arousal during sleep and thus causes restlessness and hangs over effects.
- Trial name
- NCT01486615
- Testing
- meloset (melatonin), stresnil ( melatonin and alprazolam), (alprax) alprazolam
- Where
- 2 sites in Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Arthroplasty, Replacement
TKA Melatonin and Sleep Quality
This randomized controlled trial (RCT) will compare the effects of melatonin vs. placebo in patients undergoing primary total knee arthroplasty (TKA). This RCT aims to study the effects melatonin has on sleep quality after TKA.
- Conditions
- Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05332717
- Testing
- Melatonin 5 mg
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York