Clinical trials: Melatonin, completed
Obesity, Morbid, Bariatric Surgery Candidate
Effects of LRYGB on Pharmacokinetics of Nine CYP Probe Drugs
Due to anatomical and physiological changes caused by the Roux-en-Y gastric bypass (RYGB) bariatric surgery, drug bioavailability after the surgery can be altered.
- Trial name
- NCT03563287
- Testing
- cocktail of nine CYP probe drugs
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- University of Eastern Finland
Epilepsy
Pilot Study of Melatonin and Epilepsy
The prevalence of epilepsy is 1% in the USA. About 30% of epilepsy patients eventually become refractory to medical treatment. Co morbid conditions are becoming as important as seizure control as these affect overall wellbeing.
- Trial name
- NCT00965575
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Osteoarthritis, Knee
Melatonin for Knee Osteoarthritis Patients
By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population.
- Trial name
- NCT06012175
- Testing
- Melatonin
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xiangya Hospital of Central South University
Substance Withdrawal Syndrome
The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program
Individuals recovering from drug and/or alcohol addiction initially experience the symptoms of acute withdrawal before experiencing the symptoms of post-acute withdrawal (PAWS).
- Trial name
- M-PAWS (NCT02431728)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Duquesne University
Dental Anxiety, Children
The Efficacy of Melatonin Patches on Dental Anxiety in Children
Statement of Problem: Dental anxiety significantly impacts dental treatment outcomes, particularly in pediatric patients. Given the side effects associated with current oral anxiolytic medications, there is a need to clinically…
- Trial name
- NCT07162272
- Testing
- Melatonin Patches
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Unipolar Depression
Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression
Depressed patients miss a night of sleep (Wake Night), then sleep at predetermined times ending at their desired sleep time. Beginning the morning following their Wake Night, patients sit in front of a bright light, continuing…
- Trial name
- WakeTherapy (NCT02750631)
- Testing
- Triple Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Diabetes, Glucose Tolerance
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene
The effect of 3 months of melatonin 4mg treatment on glucose tolerance in different variants of the melatonin receptor 1B gene will be evaluated.
- Trial name
- MELAG (NCT01705639)
- Testing
- Melatonin
- Where
- 2 sites in Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Schizophrenia, Schizoaffective Disorder
Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
Atypical antipsychotic medications, such as olanzapine, cause metabolic side effects, including weight gain, extra fat around the middle of the body, high blood sugar, and high cholesterol.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Obesity
- Trial name
- NCT00512070
- Testing
- olanzapine and melatonin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Spinal Cord Injured, Tetraplegia
The Role of Melatonin in the Regulation of Blood Coagulation
The main aim is to examine the influence of daylight and melatonin on the temporal variations of hemostatic factors with key roles in the hemostatic process and its regulation.
- Trial name
- COME (NCT01741389)
- Testing
- Melatonin ("Circadin")
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Dental Implants, Immediate Implant Placement
Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration
This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar…
- Conditions
- Dental Implants, Immediate Implant Placement, Osseointegration
- Trial name
- NCT07610876
- Testing
- Autologous Demineralized Dentin Graft, Melatonin gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Seasonal Affective Disorder, Healthy
Clinical Trial of Propranolol for Seasonal Affective Disorder
The purpose of this study is to determine what dose of a new timed-release tablet of the drug propranolol will reduce secretion of the hormone melatonin in healthy volunteers.
- Trial name
- NCT00016666
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Melatonin, Pharmacokinetics
Pharmacokinetics of Intravenous, Rectal, Intravesical, Vaginal, and Transdermal Melatonin in Healthy Female Volunteers
We will investigate the safety and pharmacokinetics of melatonin, when administered rectally, intravesically, vaginally and transdermally. We will recruit 10 healthy female volunteers.
- Conditions
- Melatonin, Pharmacokinetics, Safety
- Trial name
- NCT03519750
- Testing
- Melatonin 25 mg
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dennis Bregner Zetner
Healthy
Use of Endogenous Melatonin and 6-hydroxymelatonin as Biomarkers for CYP1A2
An observational study comprising 4 sessions will be conducted in 12 healthy volunteers. During each study session (sessions 1 to 4), a 12-hour urine collection during the night (21h-9h) will be carried out by each participant.
- Trial name
- MelaCYP (NCT04420611)
- Testing
- Session 1 (day 1), Session 2 (day 3), Session 3 (day 15)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Youssef Daali
Second Generation Antipsychotic Induced Metabolic Adverse Effects
Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics
Schizophrenia and bipolar disorder are frequently associated with an elevated risk for obesity, metabolic syndrome, diabetes mellitus, dyslipidemia and other metabolic disturbances.
- Trial name
- NCT01811160
- Testing
- Melatonin
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Insomnia, Spinal Cord Injury
Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
The purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep…
- Conditions
- Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
- Trial name
- NCT00507546
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Human Endotoxaemia
Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia
This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days: day 1: On day time administration of LPS. day 2: On night time administration of LPS.
- Trial name
- NCT01087359
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Prehypertension, Healthy
Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets
The investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.
- Trial name
- NCT03178396
- Testing
- melatonin
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pneumonia, Viral, Covid19
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19
Introduction: SARS-CoV2 infection produces severe pneumonia with pulmonary alveolar collapse. There is no specific treatment to date.
- Conditions
- Pneumonia, Viral, Covid19, ARDS, Oxidative Stress
- Trial name
- ANTIOX-COVID (NCT04570254)
- Testing
- Vitamin C, Vitamin E, Melatonin
- Where
- Mexico
- Volunteers
- 110 people
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Developmental Delay Disorders, Chromosome Deletion
Treatment Strategies for Children With Smith-Magenis Syndrome
This study will examine the effect of bright light or melatonin treatment on sleep in children with Smith-Magenis syndrome (SMS), a genetic disorder characterized by certain physical, behavioral and developmental features.
- Conditions
- Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00506259
- Testing
- dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Human Genome Research Institute (NHGRI)