Clinical trials: Melatonin, completed
Sleep
Effect of a Novel Melatonin Supplement on Sleep Quality
Melatonin is a hormone naturally found in our body that increases in our blood at night and controls how we sleep. Melatonin can also be taken as a pill and numerous clinical trials have documented improved sleep quality…
- Trial name
- I-MASQ (NCT06215573)
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Anterior Segment Ischemia (Diagnosis)
Effects of Selenium and Melatonin on Ocular Ischemic Syndrome
ABSTRACT: PURPOSE: To determine the effects of selenium, melatonin and selenium + melatonin administered for one month on anterior chamber (AC ) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with Ocular…
- Trial name
- NCT04005222
- Testing
- SELENIUM, MELATONIN
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beytepe Murat Erdi Eker State Hospital
Migraine
Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine
The purpose of this study is to determine the effectiveness of melatonin 3 mg compared to placebo and amitriptyline 25 mg in the preventive treatment of migraine.
- Trial name
- EDUMAP (NCT01357031)
- Testing
- Amitriptyline, Melatonin
- Where
- Brazil
- Volunteers
- 192 people
- Sponsor
- Hospital Israelita Albert Einstein
Infertility, Infertility (IVF Patients)
Melatonin Supplementation in Ovarian Response
Melatonin is a potent antioxidant, has been proposed to improve ovarian response and oocyte quality in assisted reproductive technologies (ART).
- Conditions
- Infertility, Infertility (IVF Patients), Infertile Women Undergoing IVF or ICSI
- Trial name
- NCT07343947
- Testing
- 5mg melatonin supplementation
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Malondialdehyde, Melatonin
Oral Melatonin as Neuroprotectant in Preterm Infants
Preterm newborns survival rates are improved, but long-term disabilities are still common. Major destructive focal lesions became less common, the most predominant lesion at present is diffuse white matter (WM damage).
- Trial name
- NCT04235673
- Testing
- melatonin
- Where
- 4 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Francesca Garofoli
Young Adults, Hypertension
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns.
- Conditions
- Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
- Trial name
- XTIME (NCT07049783)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Freda Patterson
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
REM Sleep Behavior Disorder
Efficacy and Safety of Melatonin and Clonazepam for IRBD
This study aimed to evaluate influence of melatonin or clonazepam treatment on symptom and polysomnographic parameters in patients with idiopathic REM sleep behavior disorder.
- Trial name
- NCT03255642
- Testing
- Melatonin 2mg, ClonazePAM 0.5 MG
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Pregnancy Transient Hypertension
Melatonin in Pregnancy Compared to Non-pregnant
Melatonin is well known for its role in the sleep-wake cycle but it is less well known as an effective antioxidant. It has been reported to be synthesised in the placenta and may have both receptor mediated and non-receptor…
- Trial name
- MEL-P (NCT03014245)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Attention Deficit Hyperactivity Disorder
Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
This study will test the efficacy of a systematic, multi-modal intervention protocol designed to improve sleep functioning and subsequent alleviation of daytime cognitive and behavioral difficulties among children diagnosed with…
- Trial name
- NCT00867451
- Testing
- Sleep Intervention, Melatonin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Preterm Neonate Analgesia
Melatonin As an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, antioxidant and anti-inflammatory effects, accumulating…
- Trial name
- NCT05971485
- Testing
- Melatonin 10 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Circadian Rhythm Disorders
Human Circadian Sensitivity to Very Short Light Pulses
The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms…
- Trial name
- NCT01330992
- Testing
- Ocular light or darkness exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain Score (VAS) at 24 h Postoperatively
Effect of Melatonin on Postoperative Pain After Simple Nephrectomy
The aim of the study is to evaluate the role of melatonin in the management of postoperative pain in patients undergoing simple nephrectomy regarding: Pain score (VAS). Total Morphine consumption is 1st 24 hr.
- Trial name
- NCT06872944
- Testing
- Melatonin, Sugar Coated Tablet
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Delayed Sleep Phase Syndrome
The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder
This study will test whether measuring the circadian clock during treatment of delayed sleep-wake phase disorder results in greater improvements in sleep compared to estimating the circadian clock.
- Trial name
- NCT03715465
- Testing
- Melatonin 0.5 MG, Dim Light Melatonin Onset (salivary)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Barrett's Esophagus
Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study
The study consists on determining whether melatonin decreases oxidative stress in Barrett's esophageal mucosa after 6 months of treatment.
- Trial name
- NCT01566474
- Testing
- Omeprazole, Melatonin
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Aragon Institute of Health Sciences
Chronic Insomnia
The Study of Combination Use of Melatonin Receptor Agonist for Dose Reduction or Interruptions of Benzodiazepine (BZD) and Non-BZD Hypnotics on Chronic Insomnia
To investigate effects on combination use of Ramelteon in the dose reduction or interruption process of (non-)BZD hypnotics during the dose reduction or interruption algorithm.
- Trial name
- BRED (NCT03461042)
- Testing
- Ramelteon 8mg
- Where
- Japan
- Volunteers
- 17 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Sarcopenia
Melatonin Plus Aminoacids for Sarcopenic Elderly
To evaluate the effectiveness of melatonin and essential aminoacid supplementation on body composition, protein metabolism, strength and inflammation.
- Trial name
- MelAASarc (NCT03784495)
- Testing
- Melatonin 1mg, Essential Aminoacids (eAA), Essential Aminoacids + melatonin
- Where
- Italy
- Volunteers
- 159 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Oral Mucositis
Melatonin Oral Gel for Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation
The main purpose of this study is to assess the efficacy of melatonin oral gel compared to placebo in the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing concurrent chemoradiation.
- Trial name
- MUCOMEL (NCT02630004)
- Testing
- Melatonin oral gel 3%
- Where
- 11 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Spherium Biomed
Glucose, Circadian Rhythm
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT02642640
- Testing
- melatonin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Polycystic Ovary Syndrome
Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome
To evaluate the effects of melatonin supplementation on the main in vitro fertilization (IVF) outcomes during ovarian stimulation in patients with Polycystic ovarian syndrome (PCOS).
- Trial name
- NCT01540747
- Testing
- Myo-inositol + folic acid + melatonin, Myo-inositol + folic acid
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre