Clinical trials: Melatonin, active
Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn
Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates
The aim of the study 1. To evaluate safety and efficacy of melatonin as an adjuvant therapy to inhaled nitric oxide generated by NO generator in the treatment of pulmonary hypertension in full term neonates. 2.
- Conditions
- Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn, Congenital Diaphragmatic Hernia
- Trial name
- NCT07850934
- Testing
- Melatonin, nitric oxide generator
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Tachycardia, Chronic Orthostatic Intolerance
Treatment of Orthostatic Intolerance
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with…
- Trial name
- NCT00262470
- Testing
- Acetazolamide, Atomoxetine, NO Drug
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
Poor Sleep Quality, Leg Cramps, Nocturnal
The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps
Participants are being invited to take part in a research study. Before deciding whether to take part, it is important for participants to understand why the research is being done and what it will involve.
- Trial name
- MISIT (NCT07651514)
- Testing
- Magnesium and melatonin based multi-ingredient dietary supplementation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- StudySetGo
Fibromyalgia
Melatonin and Immunonutrition for Pain Relief in Fibromyalgia
Fibromyalgia (FMS) is characterized by chronic musculoskeletal pain, sleep disturbances, and fatigue. It is not entirely clear how Bcomplex vitamins affect the human pain system, while at the same time there have been approaches…
- Trial name
- NCT07863232
- Testing
- Melatonin 1mg and intravenous B-complex vitamin drip
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Laparoscopic Cholecystectomy, Postoperative Quality of Recovery
Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is one of the most commonly performed abdominal surgical procedures worldwide. Although the widespread implementation of Enhanced Recovery after Surgery (ERAS) protocols has improved perioperative…
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Quality of Recovery, Preoperative Anxiety, Postoperative Sleep Quality
- Trial name
- MEL-REC (NCT07553143)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- Bangladesh
- Volunteers
- 84 people
- Sponsor
- Armed Forces Medical Institute Bangladesh
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Sleep, Fatigue
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and…
- Conditions
- Sleep, Fatigue, Anxiety, Cancer
- Trial name
- NCT05474846
- Testing
- Melatonin, Methylphenidate
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- M.D. Anderson Cancer Center
Atopic Dermatitis
Oral Melatonin as Adjunctive Therapy in Adults With Atopic Dermatitis
Atopic dermatitis is a chronic inflammatory skin disease that is commonly associated with itching, sleep disturbance, and impaired quality of life.
- Trial name
- MEL-AD (NCT07842900)
- Testing
- Melatonin, Standard Treatment for Atopic Dermatitis
- Volunteers
- 130 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Insomnia, Insomnia Disorder
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for…
- Conditions
- Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
- Trial name
- NCT07542756
- Testing
- Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pennsylvania
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Chronic Low-back Pain (cLBP)
Melatonin for Patients With Chronic Low Back Pain
Low back pain is one of the conditions causing more disability worldwide. The use of pain medications is substantial in patients with chronic LBP. But the efficacy of commonly used analgesics is modest.
- Trial name
- MELBACK (NCT06859957)
- Testing
- Melatonin 10 mg
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- Bart Koes
Insomnia, Aging
Efficacy of CBT-I With Adjuvant Melatonin in Older Adults Chronic Insomnia
This study tests the efficacy of cognitive behavioural therapy for insomnia (CBT-I) with or without adjunct melatonin in older adults with insomnia.
- Conditions
- Insomnia, Aging, Sleep Disorders
- Trial name
- SOAM (NCT07695246)
- Testing
- Cognitive behavioural therapy for insomnia, Melatonin 3 mg immediate-release, Psychoeducation
- Where
- Hong Kong
- Volunteers
- 183 people
- Sponsor
- The University of Hong Kong
Idiopathic Hypersomnia
a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: a Prospective, Double Bind, Randomized, Placebo-controlled -Trial
Idiopathic hypersomnia (IH) is a chronic disabling disorder characterized by excessive daytime sleepiness (EDS), prolonged nighttime sleep and sleep inertia.
- Trial name
- HyperChrono (NCT06252571)
- Testing
- - Melatonin - Active light ttherapy
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Emergence Delirium
MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children
Postoperative agitation and emergence delirium describe a spectrum of symptoms of early postoperative negative behavior, in which the child experiences a variety of behavioral disturbances including crying, thrashing, and…
- Trial name
- MELA-PAED (NCT05541276)
- Testing
- Melatonin, Isotonic sodium chloride solution
- Where
- Denmark
- Volunteers
- 676 people
- Sponsor
- Arash Afshari
Perimenopause, Hypertension
Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.
- Trial name
- NCT06826755
- Testing
- Terry Naturally® melatonin 5mg SR
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder (MDD) With Insomnia
Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia
Major Depressive Disorder (MDD) affects 5% of the global population and is the second leading cause of disability worldwide. Despite the widespread use of antidepressants, 50-60% of patients do not respond adequately after 8…
- Trial name
- CombiChronoS (NCT07120880)
- Testing
- AD + SHR + active LT and extended-release melatonin 2mg
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Use Disorder, Sleep Disturbance
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use…
- Trial name
- MOUD (NCT06104280)
- Testing
- Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
IBD (Inflammatory Bowel Disease)
Efficacy of Melatonin Treatment on Sleep Quality Improvement in Inflammatory Bowel Disease Patients With Clinical Remission
Sleep disturbances are common in patients with inflammatory bowel disease (IBD) and are associated with increased disease activity and reduced quality of life.
- Trial name
- Melatonin IBD (NCT07737665)
- Testing
- Melatonin ("Circadin")
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Mahidol University
Migraine Disorders
Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine
This randomized controlled trial evaluated whether adding melatonin to propranolol provided better prevention of migraine in children than propranolol alone.
- Trial name
- NCT07743255
- Testing
- Melatonin, Propranolol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University