Clinical trials: Metformin, completed
Oral Submucous Fibrosis
Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis
The goal of this clinical trial is to learn if metformin and antifibrotic drugs (pirfenidone) can modulate fibrosis and improve treatment outcomes in patients with oral submucous fibrosis (OSF).
- Trial name
- "FIBR-MET-PF" (NCT06871904)
- Testing
- Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Ziauddin University
Healthy
A Relative Bioavailability Study of Metformin HCl 750 mg ER Tablets Under Non-fasting Conditions
The purpose of this study is compare the relative bioavailability of 750 mg Metformin Hydrochloride Extended Release Tablets by Purepac Pharmaceutical Co with that of 750 mg GLUCOPHAGE® XR Tablets by Bristol-Myers Squibb Company…
- Trial name
- NCT00865852
- Testing
- Metformin HCl 750 mg Extender Release tablets, single dose, GLUCOPHAGE® XR 750 mg tablets, single dose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Type 2 Diabetes Mellitus
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the…
- Trial name
- SmartAge (NCT04841668)
- Testing
- Metformin
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Healthy
Bioequivalence Study of Metformin Hydrochloride Liquid 500mg/ 5 mL Under Fed Conditions
The objective of this study was to compare the single-dose oral bioavailability of metformin hydrochloride (HCI) liquid 500 mg/5 mL of Ranbaxy with GlucophageA® 1000 mg tablets of Bristol-Myers, USA following administration of a…
- Trial name
- NCT00780013
- Testing
- metformin hydrochloride liquid 500 mg per 5 mL
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin
Primary Objective: To demonstrate the superiority of Sotagliflozin versus placebo on hemoglobin A1c (HbA1c) reduction in participants with type 2 diabetes (T2D) who have inadequate glycemic control with metformin.
- Trial name
- NCT02926950
- Testing
- Sotagliflozin (SAR439954), Metformin
- Where
- 93 sites in United States, Canada and 2 more
- Volunteers
- 518 people
- Sponsor
- Lexicon Pharmaceuticals
Healthy
5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting
This study will compare the relative bioavailability (rate and extent of absorption) of 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets manufactured by TEVA Pharmaceutical Industries, Ltd., and distributed by TEVA…
- Trial name
- NCT00835497
- Testing
- 5 mg/500 mg Glipizide Metformin Hydrochloride Tablets, 5 mg/500 mg METAGLIP™ Tablets
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Polycystic Ovary Syndrome (PCOS)
Amelioration of Polycystic Ovary Syndrome Related Disorders by Supplementation of Thymoquinone and Metformin
Objective: To investigate the potential benefit of adding Thymoquinone to Metformin in alleviating symptoms of polycystic ovarian syndrome. Methods: 207 overweight and obese PCOS Patients were divided into two groups.
- Trial name
- NCT04852510
- Testing
- Metformin Versus a combination of Metformin and Thymoquinone (TQ)
- Where
- Saudi Arabia
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Saudi German Hospital - Madinah
Diabetes, Healthy
Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to investigate the influence of oral semaglutide on pharmacokinetics (the exposure of the trial drug in the body) of metformin and digoxin in healthy subjects.
- Trial name
- NCT02249910
- Testing
- semaglutide, metformin, digoxin
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Gestational Diabetes
Metformin Compared to Glyburide in Gestational Diabetes
Our hypothesis is that metformin and glyburide will have equal efficacy in controlling blood glucose in gestational diabetics with no increase in adverse maternal, fetal or neonatal outcomes.
- Trial name
- NCT00965991
- Testing
- metformin, Glyburide
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Type 2 Diabetes Mellitus
Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes
The purpose of this study is determine if Metformin XR monotherapy in subjects with type 2 diabetes is non-inferior to Metformin IR monotherapy
- Trial name
- NCT01864174
- Testing
- Metformin XR, Metformin IR
- Where
- 156 sites in United States, Canada and 8 more
- Volunteers
- 1,736 people
- Sponsor
- Bristol-Myers Squibb
Insulin Resistance, Postmenopause
Insulin Resistance and Testosterone in Women
The purpose of this research study is to determine if a relationship between insulin resistance (IR) and testosterone (T) exists in women who have already gone through menopause.
- Trial name
- NCT00123110
- Testing
- metformin, leuprolide injection
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hyperglycemia
Investigating the Role of the Polyol Pathway in the Central Nervous System
Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia.
- Trial name
- NCT02272556
- Testing
- Brain MRS during hyperglycemic clamp, Analysis of Metabolites in cerebrospinal fluid
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Repaglinide and Metformin Combined in Type 2 Diabetes
This trial is conducted in Asia. The aim of this trial is to investigate the efficacy of blood glucose control with combination therapy of repaglinide and metformin compared to conventional treatment with a sulphonylurea or…
- Trial name
- NCT00568984
- Testing
- repaglinide, metformin, glicazide
- Where
- 15 sites in China, Malaysia and 2 more
- Volunteers
- 324 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Safety and Efficacy Study of Canagliflozin in Older Patients (55 to 80 Years of Age) With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in older patients (55 to 80 years of age) with type 2 diabetes mellitus (T2DM) with inadequate control…
- Trial name
- NCT01106651
- Testing
- Canagliflozin 100 mg, Canagliflozin 300 mg, Antihyperglycemic agent(s)
- Where
- 86 sites in United States, Australia and 15 more
- Volunteers
- 716 people
- Sponsor
- Janssen Research & Development, LLC
Type 2 Diabetes
Efficacy and Safety of HRS-7535 Tablets in T2DM Subjects Poorly Controlled With Metformin and SGLT2i.
2 weeks screening period, 3 weeks run-in period, 16 weeks double-blind treatment period, to evaluate the Safety and Efficacy of HRS-7535 in Subjects with Type 2 Diabetes who have Inadequate Glycemic Control on Metformin and…
- Trial name
- NCT06393348
- Testing
- HRS-7535
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Type 2 Diabetes Mellitus
Safety and Efficacy of XOMA 052 in Subjects With Type 2 Diabetes Mellitus on Stable Metformin Monotherapy
The study hypothesis is that XOMA 052 improves glycemic control in subjects with Type 2 Diabetes. Study X052078 is designed to establish efficacious dose(s) for future studies based on improvement in HbA1c.
- Trial name
- NCT01066715
- Testing
- XOMA 052
- Where
- 67 sites in United States
- Volunteers
- 421 people
- Sponsor
- XOMA (US) LLC
Diabetes Mellitus, Type 2
A Randomized Trial of Diabetes Prevention Through Lifestyle Change in India
People from the Indian subcontinent are more likely to get diabetes, even at younger ages. The Diabetes Community Lifestyle Improvement Program (D-CLIP) will test in a randomized trial if a culturally specific, community-based…
- Trial name
- D-CLIP (NCT01283308)
- Testing
- Lifestyle Intervention, Standard of Care
- Where
- India
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- Emory University
Non-alcoholic Fatty Liver Disease, Liver Fibrosis
Clinical Trials Using HepatoKeeper Herbal Essentials to Treat Non-alcoholic Fatty Liver Disease and Metabolic Factors
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally, with an estimated prevalence of approximately 15 to 30%.
- Conditions
- Non-alcoholic Fatty Liver Disease, Liver Fibrosis, Liver Injury
- Trial name
- NCT06244550
- Testing
- Ganwei, Metformin
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei City Hospital
Type 2 Diabetes Mellitus, Glucotoxicity
Comparative Study of Sitagliptin and Gliclazide With Metformin in Type 2 Diabetes Patients With Glucotoxicity
This study compares the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets versus metformin in treatment-naïve patients with type 2 diabetes mellitus (T2DM) and glucotoxicity.
- Trial name
- SG Metformin (NCT06613750)
- Testing
- Sitagliptin and Gliclazide, Metformin
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Zhibin Xu
Polycystic Ovary Syndrome
Combined Metformin and Clomiphene Citrate (CC) or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to compare and determine the efficacy of combined metformin and Clomiphene citrate administration to that of laparoscopic ovarian diathermy (LOD) in infertile women with Polycystic ovary syndrome…
- Trial name
- NCT00969631
- Testing
- metformin HCl (Cidophage®; CID,Cairo, Egypt), CC (Clomid®; Global Napi Pharmaceuticals,Cairo, Egypt),Cairo, Egypt), Laparoscopic ovarian diathermy (LOD)
- Where
- Egypt
- Volunteers
- 282 people
- Sponsor
- Mansoura University
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